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Issue 10, 2012
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Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions

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Abstract

This review describes important recent advancements in asymmetric cycloisomerization reactions. A wide variety of catalytic and asymmetric strategies have been applied to these reactions over the past twenty years. Cycloisomerization reactions have the ability to produce diverse polycyclic compounds in excellent yields and selectivity. They constitute a powerful and efficient strategy for asymmetric carbon-carbon bond formation in cyclic compounds. Enyne and related olefin cyclizations comprise the majority of reactions of this type and important advances have recently occurred in this area. However, significant changes have also occurred in the area of classical cyclization as well as intramolecular hydroacylation and C–H activation initiated cyclization and these will also be described.

Graphical abstract: Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions

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Article information


Submitted
30 Apr 2012
Accepted
07 Jun 2012
First published
26 Jun 2012

Chem. Sci., 2012,3, 2899-2919
Article type
Minireview

Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions

I. D. G. Watson and F. D. Toste, Chem. Sci., 2012, 3, 2899
DOI: 10.1039/C2SC20542D

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