Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization
Biomaterial-assisted photoimmunotherapy for cancer
The biomaterials have been well designed as photoabsorbing/sensitizing agents or effective carriers to enhance the photoimmunotherapeutic efficacy and evade their side effects.
Revisiting Gene Delivery to the Brain: Silencing and Editing
Biomaterial strategies to replicate gynecological tissue
Properties of native tissue can inspire biomimetic in vitro models of gynecological disease.
Engineered drug-loaded cells and cell derivatives as a delivery platform for cancer immunotherapy
Recent advances in improving cancer immunotherapy have been summarized with a focus on using functionalized intact cells and cell derivatives.
Biomaterial-based approaches to engineering immune tolerance
The development of biomaterial-based therapeutics to induce immune tolerance holds great promise for the treatment of autoimmune diseases, allergy, and graft rejection in transplantation.
Materials promoting viral gene delivery
This review discusses the progress in developing materials that enhance viral transduction, including polymers, peptides, lipids, nanoparticles, and small molecules.
Engineering extracellular vesicles for cancer therapy: recent advances and challenges in clinical translation
Extracellular vesicles have shown great advantages in cancer therapy, but there are still huge challenges to be overcome to implement their wide clinical application.
Biomaterials-based approaches to model embryogenesis
Biomaterials are emerging as invaluable tools to investigate key mechanisms of human development using advance in vitro models. Nanomaterials can contribute to further refine these models.
Evaluating medical device and material thrombosis under flow: current and emerging technologies
This review highlights the importance of flow in medical device thrombosis and explores current and emerging technologies to evaluate dynamic biomaterial Thrombosis in vitro.
Hydrogel facilitated bioelectronic integration
Functional hydrogels show great potential for promoting the structural integration and signal transduction at bio/electronic interfaces.
Immunostimulatory biomaterials to boost tumor immunogenicity
This review highlights recent progress to develop biomaterials that boost tumor immunogenicity and improve the response rate to cancer immunotherapies.
A call for action to the biomaterial community to tackle antimicrobial resistance
The global surge of antimicrobial resistance (AMR) is a major concern for public health and proving to be a key challenge in modern disease treatment, requiring action plans at all levels.
Functional zwitterionic biomaterials for administration of insulin
This review summarizes the structures and biomedical applications of zwitterionic biomaterials in the administration of insulin.
Polydopamine free radical scavengers
This feature article summarizes the recent progress, challenges and future directions of free radical scavengers based on polydopamine, including the integrated mechanism, current regulating strategies, and kinds of biomedical applications.
The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives
Nanomedicine research has increased drastically over the past ten years, however, before clinical translation many regulatory factors must be considered.
Development of a stack, porous silk scaffold neuroblastoma model for investigating spatial differences in cell and drug responsiveness
Peptide modified polycations with pH triggered lytic activity for efficient gene delivery
C6M3 peptide modified polycations can mediate efficient gene delivery through pH triggered lytic activity for endo/lysosomal escape.
Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection
In this article, we describe a silver-decorated, light-activatable polymeric antimicrobial with strong synergistic chemo-photodynamic effect to combat bacterial infections.
Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles
Collagen-glycosaminoglycan scaffolds are functionalized with alginate that responds to ultrasound by releasing nanoparticles on-demand for coordinated wound healing.
Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin
Targeted delivery of chemotherapeutics to cancer cells has the potential to yield high drug concentrations in cancer cells while minimizing any unwanted side effects.
Polymer-loaded hydrogels serve as depots for lactate and mimic “cold” tumor microenvironments
Peptide hydrogels loaded with granulocyte-macrophage colony stimulating factor and poly-(lactic-co-glycolic acid) microparticles can recapitulate lactate concentrations and the immunosuppressive nature of the tumor microenvironment.
Fe3O4@GO magnetic nanocomposites protect mesenchymal stem cells and promote osteogenic differentiation of rat bone marrow mesenchymal stem cells
Fe3O4@GO/BMP2 protecting mesenchymal stem cells by regulating reactive oxygen species and promoting osteogenic differentiation of cells.
Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering
Macroporous and mechanically reinforced sequential IPN hydrogels combine the biological activity of fibrin with the robust mechanical properties of PEG to generate advanced scaffolds for dermal tissue engineering.
Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering
Silk photo-lyogels fabricated by di-tyrosine photo-crosslinking and ice-templating silk fibroin on 3D printed templates toward in situ tissue engineering applications.
Thermostabilization of viruses via complex coacervation
Complex coacervation shows promise as a strategy to improve the thermal stability of viruses for use in vaccine formulations.
Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium
Immune modulatory alginate encapsulation platform can be used in the pericardial space to provide enhanced therapeutic efficacy to the heart.
Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release
A novel cyclic graft polymeric prodrug with heterogeneous grafts of hydrophilic oligo (ethylene glycol) and reducibly conjugated camptothecin was synthesized with greater in vitro cytotoxicity against cancer cells than the linear graft analogues.
Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies
Rapamycin encapsulated in mono-(6-amino-6-deoxy)-beta cyclodextrin efficiently expands regulatory T cells for cell-based immunotherapy.
About this collection
Biomaterials Science is proud to present this 2021 Emerging Investigators collection. This collection gathers the very best work from biomaterials scientists in the early stages of their independent careers. The 2021 Biomaterials Science Emerging Investigators were individually nominated by members of the journal Editorial and Advisory Boards, and previous Emerging Investigators, in recognition of their potential to influence future directions in the field of biomaterials.
Articles will be added to this collection as and when they are ready to be published, accompanied by an Editorial piece in the coming months.
Congratulations to all those whose work is featured. Join us in celebrating their contributions!