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Themed collection Biomaterials Science Emerging Investigators 2021

29 items
Accepted Manuscript - Minireview

Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization

Minireview

Biomaterial-assisted photoimmunotherapy for cancer

The biomaterials have been well designed as photoabsorbing/sensitizing agents or effective carriers to enhance the photoimmunotherapeutic efficacy and evade their side effects.

Graphical abstract: Biomaterial-assisted photoimmunotherapy for cancer
Accepted Manuscript - Review Article

Revisiting Gene Delivery to the Brain: Silencing and Editing

Review Article

Biomaterial strategies to replicate gynecological tissue

Properties of native tissue can inspire biomimetic in vitro models of gynecological disease.

Graphical abstract: Biomaterial strategies to replicate gynecological tissue
Review Article

Engineered drug-loaded cells and cell derivatives as a delivery platform for cancer immunotherapy

Recent advances in improving cancer immunotherapy have been summarized with a focus on using functionalized intact cells and cell derivatives.

Graphical abstract: Engineered drug-loaded cells and cell derivatives as a delivery platform for cancer immunotherapy
Review Article

Biomaterial-based approaches to engineering immune tolerance

The development of biomaterial-based therapeutics to induce immune tolerance holds great promise for the treatment of autoimmune diseases, allergy, and graft rejection in transplantation.

Graphical abstract: Biomaterial-based approaches to engineering immune tolerance
Open Access Review Article

Materials promoting viral gene delivery

This review discusses the progress in developing materials that enhance viral transduction, including polymers, peptides, lipids, nanoparticles, and small molecules.

Graphical abstract: Materials promoting viral gene delivery
Review Article

Engineering extracellular vesicles for cancer therapy: recent advances and challenges in clinical translation

Extracellular vesicles have shown great advantages in cancer therapy, but there are still huge challenges to be overcome to implement their wide clinical application.

Graphical abstract: Engineering extracellular vesicles for cancer therapy: recent advances and challenges in clinical translation
Open Access Review Article

Biomaterials-based approaches to model embryogenesis

Biomaterials are emerging as invaluable tools to investigate key mechanisms of human development using advance in vitro models. Nanomaterials can contribute to further refine these models.

Graphical abstract: Biomaterials-based approaches to model embryogenesis
Review Article

Evaluating medical device and material thrombosis under flow: current and emerging technologies

This review highlights the importance of flow in medical device thrombosis and explores current and emerging technologies to evaluate dynamic biomaterial Thrombosis in vitro.

Graphical abstract: Evaluating medical device and material thrombosis under flow: current and emerging technologies
Review Article

Hydrogel facilitated bioelectronic integration

Functional hydrogels show great potential for promoting the structural integration and signal transduction at bio/electronic interfaces.

Graphical abstract: Hydrogel facilitated bioelectronic integration
Review Article

Immunostimulatory biomaterials to boost tumor immunogenicity

This review highlights recent progress to develop biomaterials that boost tumor immunogenicity and improve the response rate to cancer immunotherapies.

Graphical abstract: Immunostimulatory biomaterials to boost tumor immunogenicity
Open Access Review Article

A call for action to the biomaterial community to tackle antimicrobial resistance

The global surge of antimicrobial resistance (AMR) is a major concern for public health and proving to be a key challenge in modern disease treatment, requiring action plans at all levels.

Graphical abstract: A call for action to the biomaterial community to tackle antimicrobial resistance
Review Article

Functional zwitterionic biomaterials for administration of insulin

This review summarizes the structures and biomedical applications of zwitterionic biomaterials in the administration of insulin.

Graphical abstract: Functional zwitterionic biomaterials for administration of insulin
Review Article

Polydopamine free radical scavengers

This feature article summarizes the recent progress, challenges and future directions of free radical scavengers based on polydopamine, including the integrated mechanism, current regulating strategies, and kinds of biomedical applications.

Graphical abstract: Polydopamine free radical scavengers
Open Access Review Article

The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives

Nanomedicine research has increased drastically over the past ten years, however, before clinical translation many regulatory factors must be considered.

Graphical abstract: The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives
Accepted Manuscript - Paper

Development of a stack, porous silk scaffold neuroblastoma model for investigating spatial differences in cell and drug responsiveness

Paper

Peptide modified polycations with pH triggered lytic activity for efficient gene delivery

C6M3 peptide modified polycations can mediate efficient gene delivery through pH triggered lytic activity for endo/lysosomal escape.

Graphical abstract: Peptide modified polycations with pH triggered lytic activity for efficient gene delivery
Paper

Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection

In this article, we describe a silver-decorated, light-activatable polymeric antimicrobial with strong synergistic chemo-photodynamic effect to combat bacterial infections.

Graphical abstract: Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection
Paper

Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles

Collagen-glycosaminoglycan scaffolds are functionalized with alginate that responds to ultrasound by releasing nanoparticles on-demand for coordinated wound healing.

Graphical abstract: Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles
Paper

Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin

Targeted delivery of chemotherapeutics to cancer cells has the potential to yield high drug concentrations in cancer cells while minimizing any unwanted side effects.

Graphical abstract: Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin
Paper

Polymer-loaded hydrogels serve as depots for lactate and mimic “cold” tumor microenvironments

Peptide hydrogels loaded with granulocyte-macrophage colony stimulating factor and poly-(lactic-co-glycolic acid) microparticles can recapitulate lactate concentrations and the immunosuppressive nature of the tumor microenvironment.

Graphical abstract: Polymer-loaded hydrogels serve as depots for lactate and mimic “cold” tumor microenvironments
Paper

Fe3O4@GO magnetic nanocomposites protect mesenchymal stem cells and promote osteogenic differentiation of rat bone marrow mesenchymal stem cells

Fe3O4@GO/BMP2 protecting mesenchymal stem cells by regulating reactive oxygen species and promoting osteogenic differentiation of cells.

Graphical abstract: Fe3O4@GO magnetic nanocomposites protect mesenchymal stem cells and promote osteogenic differentiation of rat bone marrow mesenchymal stem cells
Paper

Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering

Macroporous and mechanically reinforced sequential IPN hydrogels combine the biological activity of fibrin with the robust mechanical properties of PEG to generate advanced scaffolds for dermal tissue engineering.

Graphical abstract: Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering
Paper

Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering

Silk photo-lyogels fabricated by di-tyrosine photo-crosslinking and ice-templating silk fibroin on 3D printed templates toward in situ tissue engineering applications.

Graphical abstract: Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering
Open Access Paper

Thermostabilization of viruses via complex coacervation

Complex coacervation shows promise as a strategy to improve the thermal stability of viruses for use in vaccine formulations.

Graphical abstract: Thermostabilization of viruses via complex coacervation
Paper

Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium

Immune modulatory alginate encapsulation platform can be used in the pericardial space to provide enhanced therapeutic efficacy to the heart.

Graphical abstract: Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium
Paper

Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release

A novel cyclic graft polymeric prodrug with heterogeneous grafts of hydrophilic oligo (ethylene glycol) and reducibly conjugated camptothecin was synthesized with greater in vitro cytotoxicity against cancer cells than the linear graft analogues.

Graphical abstract: Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release
Paper

Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies

Rapamycin encapsulated in mono-(6-amino-6-deoxy)-beta cyclodextrin efficiently expands regulatory T cells for cell-based immunotherapy.

Graphical abstract: Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies
29 items

About this collection

Biomaterials Science is proud to present this 2021 Emerging Investigators collection. This collection gathers the very best work from biomaterials scientists in the early stages of their independent careers. The 2021 Biomaterials Science Emerging Investigators were individually nominated by members of the journal Editorial and Advisory Boards, and previous Emerging Investigators, in recognition of their potential to influence future directions in the field of biomaterials.

Articles will be added to this collection as and when they are ready to be published, accompanied by an Editorial piece in the coming months.

Congratulations to all those whose work is featured. Join us in celebrating their contributions!

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