Themed collection Biomaterials Science 10th Anniversary Collection

43 items
Editorial

Ten years of Biomaterials Science

An editorial from Jianjun Cheng and Maria Southall on the celebration of the journal's 10th anniversary.

Graphical abstract: Ten years of Biomaterials Science
Open Access Accepted Manuscript - Minireview

Development of substrates for the culture of human pluripotent stem cells

Open Access Minireview

Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

With the alarming and prevailing antimicrobial resistance (AMR) comes an urgent need for novel biocompatible antimicrobial agents that are not only effective and robust but also do not induce resistance development

Graphical abstract: Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?
Review Article

Engineering optical tools for remotely controlled brain stimulation and regeneration

This review covers the latest progress in the application of light-responsive nanomaterials for on-demand drug delivery to the brain and for neuromodulation, with the aim of achieving brain stimulation and regeneration.

Graphical abstract: Engineering optical tools for remotely controlled brain stimulation and regeneration
Accepted Manuscript - Review Article

3D bioprinting complex models of cancer

Review Article

Recent strategies to develop pH-sensitive injectable hydrogels

Amphoteric pH-responsive polymers fused with both acidic and basic polymers exhibited sharp pH-swelling behavior in both acidic and basic media.

Graphical abstract: Recent strategies to develop pH-sensitive injectable hydrogels
Review Article

Expanding opportunities to engineer mucosal vaccination with biomaterials

Here we discuss material strategies for mucus penetration to deliver mucosal vaccines, including polymeric coatings, microneedle arrays, self-propulsion, mucus disruption, receptor targeting, and pathogen inspired methods. Created with Biorender.com.

Graphical abstract: Expanding opportunities to engineer mucosal vaccination with biomaterials
Review Article

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

This review provides a comprehensive overview of the state-of-the-art progress in nanotechnology-based strategies for interfering with the biofilm life cycle according to the requirements of different stages.

Graphical abstract: Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms
Open Access Review Article

Biomedically-relevant metal organic framework-hydrogel composites

MOF-hydrogel composites are an emerging class of composite materials with many potential biomedical applications. In this review article, we discuss the state-of-the-art and prospects for future development.

Graphical abstract: Biomedically-relevant metal organic framework-hydrogel composites
Review Article

Engineered bacteria for augmented in situ tumor vaccination

Engineered bacteria can be leveraged for in situ tumor vaccinations with their tumor-targeting ability and adjuvanticity. Engineering strategies like chemical modification, nanotechnology, and genetic engineering improve their safety and efficacy.

Graphical abstract: Engineered bacteria for augmented in situ tumor vaccination
Review Article

Multivalent sialic acid materials for biomedical applications

In this review, we will briefly introduce the biomedical function of sialic acids in organisms and the utilization of multivalent sialic acid materials for targeted drug delivery as well as therapeutic applications including anti-inflammation and anti-viruses.

Graphical abstract: Multivalent sialic acid materials for biomedical applications
Review Article

Recent advances in responsive antibacterial materials: design and application scenarios

Recent development in stimuli-responsive antibacterial materials is reviewed with particular focus on smart systems that can be tailored by intrinsic and external stimuli for selective and localized activation and treatment of specific diseases.

Graphical abstract: Recent advances in responsive antibacterial materials: design and application scenarios
Review Article

Pharmaceutical liposomal delivery—specific considerations of innovation and challenges

Liposomal technology can enhance drug solubility and stability, achieving codelivery for combination therapy, and modulate the in vivo fate (e.g., site-specific distribution and controlled release), thereby improving treatment outcomes.

Graphical abstract: Pharmaceutical liposomal delivery—specific considerations of innovation and challenges
Review Article

Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications

Herein, the emerging advances in some exogenous stimuli and endogenous stimuli responsive systems of ZnO-based nanomaterials in biomedical applications are highlighted, while their advantages and directions for improvement are also pointed out.

Graphical abstract: Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications
Communication

Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy

Herein, we report a facile approach for the preparation of two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility via an aqueous solvent-assisted ultrasonic route.

Graphical abstract: Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy
Paper

In vivo evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts

Synthetic vascular grafts with varied compliance were fabricated and studied in vivo. Reducing compliance mismatch between graft and native artery lowered intimal hyperplasia formation and increased graft patency.

Graphical abstract: In vivo evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts
Paper

Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles

We report herein the delivery of bacterial effector protein DUF5 using bioreducible lipid nanoparticles for mutant RAS degradation and downstream cell signalling reprogramming for cancer therapy.

Graphical abstract: Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles
Paper

Development of lipidated polycarbonates with broad-spectrum antimicrobial activity

Lipidated polycarbonates display broad-spectrum antimicrobial activity.

Graphical abstract: Development of lipidated polycarbonates with broad-spectrum antimicrobial activity
Paper

Histidine-based coordinative polymers for efficient intracellular protein delivery via enhanced protein binding, cellular uptake, and endosomal escape

Histidine-based coordinative polymers overcome multiple barriers, and achieve efficient cytosolic protein delivery.

Graphical abstract: Histidine-based coordinative polymers for efficient intracellular protein delivery via enhanced protein binding, cellular uptake, and endosomal escape
Paper

Immunogenicity assessment of swim bladder-derived biomaterials

The swim bladder-derived material did not elicit significant aberrant immune responses by in vitro and in vivo assays, giving strong confidence for its application in tissue engineering or medical devices.

Graphical abstract: Immunogenicity assessment of swim bladder-derived biomaterials
Paper

A natural polyphenol-functionalized chitosan/gelatin sponge for accelerating hemostasis and infected wound healing

A multifunctional natural polyphenol-functionalized chitosan/gelatin sponge (PCGS) is reported for hemostatic and infected wound therapy.

Graphical abstract: A natural polyphenol-functionalized chitosan/gelatin sponge for accelerating hemostasis and infected wound healing
Paper

Nitric oxide scavengers based on o-phenylenediamine for the treatment of rheumatoid arthritis

We discovered an o-PD-based NO scavenger that is highly reactive with NO as an agent for RA treatment. We believe that the N-Me has potential applications for developing anti-inflammatory disease treatments targeting NO.

Graphical abstract: Nitric oxide scavengers based on o-phenylenediamine for the treatment of rheumatoid arthritis
Paper

Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)

Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.

Graphical abstract: Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
Paper

Thermoresponsive shear-thinning hydrogel (T-STH) hemostats for minimally invasive treatment of external hemorrhages

p(NIPAM) and LAPONITE®-based thermoresponsive shear-thinning hydrogel (T-STH) hemostats are designed to function as reversible hemostats for emergency situations. They exhibit temperature dependent coagulation and improved clotting times.

Graphical abstract: Thermoresponsive shear-thinning hydrogel (T-STH) hemostats for minimally invasive treatment of external hemorrhages
Paper

Endogenous stimulus-responsive nitric oxide releasing bioactive liposome for a multilayered drug-eluting balloon

Drug eluting balloon (DEB) system has been designed to enable synergistic therapeutic effects with nitric oxide while reducing the amount of cytostatic drug (EVL), along with the various advantages expected by using a multilayer coating strategy.

Graphical abstract: Endogenous stimulus-responsive nitric oxide releasing bioactive liposome for a multilayered drug-eluting balloon
Paper

Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair

Baicalein was discovered to direct neuronal differentiation. Based on this, a baicalein functionalized collagen scaffold (BFCS) was developed for spinal cord injury (SCI) repair, which enhanced neurogenesis and motor functional recovery of SCI rats.

Graphical abstract: Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair
Paper

An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing

A double-layer microneedle patch DMN@TCH/DFO was prepared and released TCH and DFO to accelerate wound healing through antibacterial and angiogenesis-promoting processes, and provides a new choice for diabetic wound repair.

Graphical abstract: An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing
Paper

Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles

Tenofovir-conjugated peptide amphiphiles can assemble and form hydrogels under physiological conditions for sustained therapeutic release. Varying the number of valines in the designs impacts their self-assembly, gelation, and release behavior.

Graphical abstract: Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles
Paper

Single-component lipid nanoparticles for engineering SOCS1 gene-silenced dendritic cells to boost tumor immunotherapy

Single-component lipid nanoparticles are designed and prepared for delivery of SOCS1 siRNA to primary DCs, which can be further pulsed with Ova-antigen to fabricate a SOCS1-downregulated DC vaccine with the potential to boost antitumor immunotherapy.

Graphical abstract: Single-component lipid nanoparticles for engineering SOCS1 gene-silenced dendritic cells to boost tumor immunotherapy
Paper

Dendritic lipopeptide liposomes decorated with dual-targeted proteins

A tumor-targeted dendritic lipopeptide liposome was developed to improve the anticancer effect of loaded drugs by enhancing tumor targeting, cancer cell endocytosis and tumor penetration.

Graphical abstract: Dendritic lipopeptide liposomes decorated with dual-targeted proteins
Paper

Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes

The incorporation of AuNRs and biodegradable BP nanosheets in scaffolds containing Dox-encapsulated thermosensitive liposomes enables synergistic PTT and chemotherapy or mild-hyperthermia-induced chemotherapy before and after BP degradation.

Graphical abstract: Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes
Paper

Sea urchin-like Bi2S3/curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light

Bi2S3/Cur photocatalysis and photothermal synergistic bactericidal effect under 808 nm near infrared light.

Graphical abstract: Sea urchin-like Bi2S3/curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light
Paper

Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates

A library of diblock HA-b-ELP bioconjugates was synthesized by a simple synthetic and purification procedure in water. Their self-assembly properties were deeply investigated to assess their structure–property relationships.

Graphical abstract: Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates
Paper

Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors

We developed a targeted nanomedicine encapsulating the liver X receptor agonist T0901317 for differentially regulating the behaviors of HUVECs and HASMCs.

Graphical abstract: Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors
Paper

Microneedle patch with “spongy coating” to co-load multiple drugs to treat multidrug-resistant melanoma

Microneedle Patch with porous spongy coating could achieve the synergistic administration of SAHA and CBP for treatment of multidrug-resistant melanoma.

Graphical abstract: Microneedle patch with “spongy coating” to co-load multiple drugs to treat multidrug-resistant melanoma
Paper

Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)

Spherical α-helical polypeptide (SPP) mediated effective E2F1 silencing in the myocardium for the treatment of ischemia reperfusion injury.

Graphical abstract: Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)
Paper

pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss

pH-Sensitive nanocarriers deliver adenosine to the bone tissue and mitigate osteoporotic-mediated bone loss through the promotion of osteoblastogenesis and inhibition of osteoclastogenesis.

Graphical abstract: pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss
Paper

Polyaspartate-derived synthetic antimicrobial polymer enhances the activity of rifampicin against multidrug-resistant Pseudomonas aeruginosa infections

Infections caused by multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) pose major challenges for treatment due to the acquired, adaptive, and intrinsic resistance developed by the bacteria.

Graphical abstract: Polyaspartate-derived synthetic antimicrobial polymer enhances the activity of rifampicin against multidrug-resistant Pseudomonas aeruginosa infections
Paper

Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination

Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable and divergent systemic immunotherapy outcomes.

Graphical abstract: Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination
Paper

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.

Graphical abstract: Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
Paper

Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

A novel strategy of tumor microenvironment reprogramming by Intra/extracellular lactic acid exhausting for antitumor immune therapy.

Graphical abstract: Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Paper

Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer

The application of MnO2@MPDA-PEG NPs for reshaping the tumor microenvironment under mild PTT inhibits tumor growth.

Graphical abstract: Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer
Paper

pH-Responsive hyaluronic acid-cloaked polycation/gold nanohybrids for tumor-targeted synergistic photothermal/gene therapy

The current work provides a facile strategy to construct multifunctional gene delivery systems with long circulation and tumor-targeting characteristics for effective tumor treatment.

Graphical abstract: pH-Responsive hyaluronic acid-cloaked polycation/gold nanohybrids for tumor-targeted synergistic photothermal/gene therapy
43 items

About this collection

September 2022 marks 10 years since the first articles were published in Biomaterials Science and as part of the celebrations for Biomaterials Science’s 10th Anniversary, we are delighted to introduce to you our 10th Anniversary Collection. Featuring high quality research and review articles from some of the top authors in biomaterials, we hope you enjoy reading this special collection.

We would like to thank all of our authors, reviewers, and readers for your incredible support since we launched and we look forward to seeing what developments the next decade will bring!

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