Themed collection Biomaterials Science 10th Anniversary Collection

An editorial from Jianjun Cheng and Maria Southall on the celebration of the journal's 10th anniversary.

With the alarming and prevailing antimicrobial resistance (AMR) comes an urgent need for novel biocompatible antimicrobial agents that are not only effective and robust but also do not induce resistance development

This review provides the latest progress of culture substrates for human pluripotent stem cells.

The emerging role of T cells, stromal cells, and senescent cells and their interactions with other cell types in the FBR are discussed in this review. Additionally, factors that modulate the phenotype of these cells are briefly considered.

Cancer is characterized by the uncontrolled division of cells, resulting in the formation of tumors. The personalized composition of biomaterials and 3D techniques can be used as a modelling tool to understand the complexity of various cancers.

This review covers the latest progress in the application of light-responsive nanomaterials for on-demand drug delivery to the brain and for neuromodulation, with the aim of achieving brain stimulation and regeneration.

MOF-hydrogel composites are an emerging class of composite materials with many potential biomedical applications. In this review article, we discuss the state-of-the-art and prospects for future development.

In this review, we will briefly introduce the biomedical function of sialic acids in organisms and the utilization of multivalent sialic acid materials for targeted drug delivery as well as therapeutic applications including anti-inflammation and anti-viruses.

Amphoteric pH-responsive polymers fused with both acidic and basic polymers exhibited sharp pH-swelling behavior in both acidic and basic media.

Here we discuss material strategies for mucus penetration to deliver mucosal vaccines, including polymeric coatings, microneedle arrays, self-propulsion, mucus disruption, receptor targeting, and pathogen inspired methods. Created with Biorender.com.

This review provides a comprehensive overview of the state-of-the-art progress in nanotechnology-based strategies for interfering with the biofilm life cycle according to the requirements of different stages.

Engineered bacteria can be leveraged for in situ tumor vaccinations with their tumor-targeting ability and adjuvanticity. Engineering strategies like chemical modification, nanotechnology, and genetic engineering improve their safety and efficacy.

Recent development in stimuli-responsive antibacterial materials is reviewed with particular focus on smart systems that can be tailored by intrinsic and external stimuli for selective and localized activation and treatment of specific diseases.

Liposomal technology can enhance drug solubility and stability, achieving codelivery for combination therapy, and modulate the in vivo fate (e.g., site-specific distribution and controlled release), thereby improving treatment outcomes.

Herein, the emerging advances in some exogenous stimuli and endogenous stimuli responsive systems of ZnO-based nanomaterials in biomedical applications are highlighted, while their advantages and directions for improvement are also pointed out.

Herein, we report a facile approach for the preparation of two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility via an aqueous solvent-assisted ultrasonic route.

Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.

Microfluidic spheroid-on-chip emulates physiologically relevant low fluid shear stress, resulting in improved PDLSC viability, enhanced osteodifferentiation, and uniform calcium deposition, offering new possibilities for periodontal research.

A cationic copolymer and a crowding agent enhance the cleavage activity of a Na⁺-dependent DNAzyme. The combination of the copolymer and crowding agent displays a cooperative effect, resulting in a 46-fold enhancement of DNAzyme activity.

Eradicating established mouse melanoma by tumor-selective chemotherapy in combination with in vivo dendritic cell targeted genetic immunization using a tumor antigen encoded DNA vaccine.

Murine myoblasts cultured on combinatorial extracellular matrix (ECM) proteins are exposed to uniaxial strain. The combined effects of ECMs and strain on myogenesis are investigated by transcriptomic and protein analyses.

Here, the efficacy of an injectable hydrogel system (NPgel), either alone or together with progenitor cells, was investigated within a degenerate loaded disc model. NPgel inhibited cellular catabolism and promoted anabolism, supporting regeneration.

Green tea-based micellar nanocomplexes (MNCs) for tumor-targeted delivery of anticancer proteins are not just drug carriers but therapeutic themselves. MNCs induce apoptosis in cancer cells with no or very low toxicity for HUVECs and kidney cells.

A facile one-step oxidation polymerization strategy was developed to construct biodegradable poly(disulfide)s (PBDBM) for redox-responsive drug delivery with reduced systemic toxicity.

Synthetic vascular grafts with varied compliance were fabricated and studied in vivo. Reducing compliance mismatch between graft and native artery lowered intimal hyperplasia formation and increased graft patency.

We report herein the delivery of bacterial effector protein DUF5 using bioreducible lipid nanoparticles for mutant RAS degradation and downstream cell signalling reprogramming for cancer therapy.

The swim bladder-derived material did not elicit significant aberrant immune responses by in vitro and in vivo assays, giving strong confidence for its application in tissue engineering or medical devices.

We discovered an o-PD-based NO scavenger that is highly reactive with NO as an agent for RA treatment. We believe that the N-Me has potential applications for developing anti-inflammatory disease treatments targeting NO.

A multifunctional natural polyphenol-functionalized chitosan/gelatin sponge (PCGS) is reported for hemostatic and infected wound therapy.

Lipidated polycarbonates display broad-spectrum antimicrobial activity.

Histidine-based coordinative polymers overcome multiple barriers, and achieve efficient cytosolic protein delivery.

Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.

p(NIPAM) and LAPONITE®-based thermoresponsive shear-thinning hydrogel (T-STH) hemostats are designed to function as reversible hemostats for emergency situations. They exhibit temperature dependent coagulation and improved clotting times.

Drug eluting balloon (DEB) system has been designed to enable synergistic therapeutic effects with nitric oxide while reducing the amount of cytostatic drug (EVL), along with the various advantages expected by using a multilayer coating strategy.

Baicalein was discovered to direct neuronal differentiation. Based on this, a baicalein functionalized collagen scaffold (BFCS) was developed for spinal cord injury (SCI) repair, which enhanced neurogenesis and motor functional recovery of SCI rats.

A double-layer microneedle patch DMN@TCH/DFO was prepared and released TCH and DFO to accelerate wound healing through antibacterial and angiogenesis-promoting processes, and provides a new choice for diabetic wound repair.

Tenofovir-conjugated peptide amphiphiles can assemble and form hydrogels under physiological conditions for sustained therapeutic release. Varying the number of valines in the designs impacts their self-assembly, gelation, and release behavior.

Single-component lipid nanoparticles are designed and prepared for delivery of SOCS1 siRNA to primary DCs, which can be further pulsed with Ova-antigen to fabricate a SOCS1-downregulated DC vaccine with the potential to boost antitumor immunotherapy.

A tumor-targeted dendritic lipopeptide liposome was developed to improve the anticancer effect of loaded drugs by enhancing tumor targeting, cancer cell endocytosis and tumor penetration.

The incorporation of AuNRs and biodegradable BP nanosheets in scaffolds containing Dox-encapsulated thermosensitive liposomes enables synergistic PTT and chemotherapy or mild-hyperthermia-induced chemotherapy before and after BP degradation.

Bi₂S₃/Cur photocatalysis and photothermal synergistic bactericidal effect under 808 nm near infrared light.

A library of diblock HA-b-ELP bioconjugates was synthesized by a simple synthetic and purification procedure in water. Their self-assembly properties were deeply investigated to assess their structure–property relationships.

We developed a targeted nanomedicine encapsulating the liver X receptor agonist T0901317 for differentially regulating the behaviors of HUVECs and HASMCs.

Microneedle Patch with porous spongy coating could achieve the synergistic administration of SAHA and CBP for treatment of multidrug-resistant melanoma.

Spherical α-helical polypeptide (SPP) mediated effective E2F1 silencing in the myocardium for the treatment of ischemia reperfusion injury.

pH-Sensitive nanocarriers deliver adenosine to the bone tissue and mitigate osteoporotic-mediated bone loss through the promotion of osteoblastogenesis and inhibition of osteoclastogenesis.

Infections caused by multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) pose major challenges for treatment due to the acquired, adaptive, and intrinsic resistance developed by the bacteria.

Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable and divergent systemic immunotherapy outcomes.

Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.

A novel strategy of tumor microenvironment reprogramming by Intra/extracellular lactic acid exhausting for antitumor immune therapy.

The application of MnO₂@MPDA-PEG NPs for reshaping the tumor microenvironment under mild PTT inhibits tumor growth.

The current work provides a facile strategy to construct multifunctional gene delivery systems with long circulation and tumor-targeting characteristics for effective tumor treatment.