Themed collection Biomaterials Science 10th Anniversary Collection
Ten years of Biomaterials Science
An editorial from Jianjun Cheng and Maria Southall on the celebration of the journal's 10th anniversary.
Development of substrates for the culture of human pluripotent stem cells
Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?
With the alarming and prevailing antimicrobial resistance (AMR) comes an urgent need for novel biocompatible antimicrobial agents that are not only effective and robust but also do not induce resistance development
Engineering optical tools for remotely controlled brain stimulation and regeneration
This review covers the latest progress in the application of light-responsive nanomaterials for on-demand drug delivery to the brain and for neuromodulation, with the aim of achieving brain stimulation and regeneration.
3D bioprinting complex models of cancer
Recent strategies to develop pH-sensitive injectable hydrogels
Amphoteric pH-responsive polymers fused with both acidic and basic polymers exhibited sharp pH-swelling behavior in both acidic and basic media.
Expanding opportunities to engineer mucosal vaccination with biomaterials
Here we discuss material strategies for mucus penetration to deliver mucosal vaccines, including polymeric coatings, microneedle arrays, self-propulsion, mucus disruption, receptor targeting, and pathogen inspired methods. Created with Biorender.com.
Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms
This review provides a comprehensive overview of the state-of-the-art progress in nanotechnology-based strategies for interfering with the biofilm life cycle according to the requirements of different stages.
Biomedically-relevant metal organic framework-hydrogel composites
MOF-hydrogel composites are an emerging class of composite materials with many potential biomedical applications. In this review article, we discuss the state-of-the-art and prospects for future development.
Engineered bacteria for augmented in situ tumor vaccination
Engineered bacteria can be leveraged for in situ tumor vaccinations with their tumor-targeting ability and adjuvanticity. Engineering strategies like chemical modification, nanotechnology, and genetic engineering improve their safety and efficacy.
Multivalent sialic acid materials for biomedical applications
In this review, we will briefly introduce the biomedical function of sialic acids in organisms and the utilization of multivalent sialic acid materials for targeted drug delivery as well as therapeutic applications including anti-inflammation and anti-viruses.
Recent advances in responsive antibacterial materials: design and application scenarios
Recent development in stimuli-responsive antibacterial materials is reviewed with particular focus on smart systems that can be tailored by intrinsic and external stimuli for selective and localized activation and treatment of specific diseases.
Pharmaceutical liposomal delivery—specific considerations of innovation and challenges
Liposomal technology can enhance drug solubility and stability, achieving codelivery for combination therapy, and modulate the in vivo fate (e.g., site-specific distribution and controlled release), thereby improving treatment outcomes.
Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications
Herein, the emerging advances in some exogenous stimuli and endogenous stimuli responsive systems of ZnO-based nanomaterials in biomedical applications are highlighted, while their advantages and directions for improvement are also pointed out.
Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy
Herein, we report a facile approach for the preparation of two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility via an aqueous solvent-assisted ultrasonic route.
In vivo evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts
Synthetic vascular grafts with varied compliance were fabricated and studied in vivo. Reducing compliance mismatch between graft and native artery lowered intimal hyperplasia formation and increased graft patency.
Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles
We report herein the delivery of bacterial effector protein DUF5 using bioreducible lipid nanoparticles for mutant RAS degradation and downstream cell signalling reprogramming for cancer therapy.
Development of lipidated polycarbonates with broad-spectrum antimicrobial activity
Lipidated polycarbonates display broad-spectrum antimicrobial activity.
Histidine-based coordinative polymers for efficient intracellular protein delivery via enhanced protein binding, cellular uptake, and endosomal escape
Histidine-based coordinative polymers overcome multiple barriers, and achieve efficient cytosolic protein delivery.
Immunogenicity assessment of swim bladder-derived biomaterials
The swim bladder-derived material did not elicit significant aberrant immune responses by in vitro and in vivo assays, giving strong confidence for its application in tissue engineering or medical devices.
A natural polyphenol-functionalized chitosan/gelatin sponge for accelerating hemostasis and infected wound healing
A multifunctional natural polyphenol-functionalized chitosan/gelatin sponge (PCGS) is reported for hemostatic and infected wound therapy.
Nitric oxide scavengers based on o-phenylenediamine for the treatment of rheumatoid arthritis
We discovered an o-PD-based NO scavenger that is highly reactive with NO as an agent for RA treatment. We believe that the N-Me has potential applications for developing anti-inflammatory disease treatments targeting NO.
Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.
Thermoresponsive shear-thinning hydrogel (T-STH) hemostats for minimally invasive treatment of external hemorrhages
p(NIPAM) and LAPONITE®-based thermoresponsive shear-thinning hydrogel (T-STH) hemostats are designed to function as reversible hemostats for emergency situations. They exhibit temperature dependent coagulation and improved clotting times.
Endogenous stimulus-responsive nitric oxide releasing bioactive liposome for a multilayered drug-eluting balloon
Drug eluting balloon (DEB) system has been designed to enable synergistic therapeutic effects with nitric oxide while reducing the amount of cytostatic drug (EVL), along with the various advantages expected by using a multilayer coating strategy.
Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair
Baicalein was discovered to direct neuronal differentiation. Based on this, a baicalein functionalized collagen scaffold (BFCS) was developed for spinal cord injury (SCI) repair, which enhanced neurogenesis and motor functional recovery of SCI rats.
An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing
A double-layer microneedle patch DMN@TCH/DFO was prepared and released TCH and DFO to accelerate wound healing through antibacterial and angiogenesis-promoting processes, and provides a new choice for diabetic wound repair.
Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles
Tenofovir-conjugated peptide amphiphiles can assemble and form hydrogels under physiological conditions for sustained therapeutic release. Varying the number of valines in the designs impacts their self-assembly, gelation, and release behavior.
Single-component lipid nanoparticles for engineering SOCS1 gene-silenced dendritic cells to boost tumor immunotherapy
Single-component lipid nanoparticles are designed and prepared for delivery of SOCS1 siRNA to primary DCs, which can be further pulsed with Ova-antigen to fabricate a SOCS1-downregulated DC vaccine with the potential to boost antitumor immunotherapy.
Dendritic lipopeptide liposomes decorated with dual-targeted proteins
A tumor-targeted dendritic lipopeptide liposome was developed to improve the anticancer effect of loaded drugs by enhancing tumor targeting, cancer cell endocytosis and tumor penetration.
Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes
The incorporation of AuNRs and biodegradable BP nanosheets in scaffolds containing Dox-encapsulated thermosensitive liposomes enables synergistic PTT and chemotherapy or mild-hyperthermia-induced chemotherapy before and after BP degradation.
Sea urchin-like Bi2S3/curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light
Bi2S3/Cur photocatalysis and photothermal synergistic bactericidal effect under 808 nm near infrared light.
Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates
A library of diblock HA-b-ELP bioconjugates was synthesized by a simple synthetic and purification procedure in water. Their self-assembly properties were deeply investigated to assess their structure–property relationships.
Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors
We developed a targeted nanomedicine encapsulating the liver X receptor agonist T0901317 for differentially regulating the behaviors of HUVECs and HASMCs.
Microneedle patch with “spongy coating” to co-load multiple drugs to treat multidrug-resistant melanoma
Microneedle Patch with porous spongy coating could achieve the synergistic administration of SAHA and CBP for treatment of multidrug-resistant melanoma.
Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)
Spherical α-helical polypeptide (SPP) mediated effective E2F1 silencing in the myocardium for the treatment of ischemia reperfusion injury.
pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss
pH-Sensitive nanocarriers deliver adenosine to the bone tissue and mitigate osteoporotic-mediated bone loss through the promotion of osteoblastogenesis and inhibition of osteoclastogenesis.
Polyaspartate-derived synthetic antimicrobial polymer enhances the activity of rifampicin against multidrug-resistant Pseudomonas aeruginosa infections
Infections caused by multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) pose major challenges for treatment due to the acquired, adaptive, and intrinsic resistance developed by the bacteria.
Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination
Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable and divergent systemic immunotherapy outcomes.
Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.
Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
A novel strategy of tumor microenvironment reprogramming by Intra/extracellular lactic acid exhausting for antitumor immune therapy.
Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer
The application of MnO2@MPDA-PEG NPs for reshaping the tumor microenvironment under mild PTT inhibits tumor growth.
pH-Responsive hyaluronic acid-cloaked polycation/gold nanohybrids for tumor-targeted synergistic photothermal/gene therapy
The current work provides a facile strategy to construct multifunctional gene delivery systems with long circulation and tumor-targeting characteristics for effective tumor treatment.
About this collection
September 2022 marks 10 years since the first articles were published in Biomaterials Science and as part of the celebrations for Biomaterials Science’s 10th Anniversary, we are delighted to introduce to you our 10th Anniversary Collection. Featuring high quality research and review articles from some of the top authors in biomaterials, we hope you enjoy reading this special collection.
We would like to thank all of our authors, reviewers, and readers for your incredible support since we launched and we look forward to seeing what developments the next decade will bring!