Issue 15, 2022

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Abstract

The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use of antibiotics in feed. Therefore, it is an urgent need to develop alternatives to antibiotics to control infectious diseases in feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent and broad-spectrum activity against common pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and do not induce bacteria to develop resistance or cross-resistance to antibiotics. The optimal peptide polymer demonstrates strong in vivo therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance.

Graphical abstract: Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2022
Accepted
26 May 2022
First published
01 Jun 2022

Biomater. Sci., 2022,10, 4193-4207

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

P. Ma, Y. Wu, W. Jiang, N. Shao, M. Zhou, Y. Chen, J. Xie, Z. Qiao and R. Liu, Biomater. Sci., 2022, 10, 4193 DOI: 10.1039/D2BM00672C

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