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Themed collection Recent HOT articles

98 items - Showing page 1 of 2
Communication

Detection of Escherichia coli bacteria by impact electrochemistry

Employing the redox species N,N,N′,N′-tetramethyl-para-phenylene-diamine (TMPD), the label-free detection of E. coli, based on an electrochemical “on”-signal during impact electrochemistry, is reported for the first time.

Graphical abstract: Detection of Escherichia coli bacteria by impact electrochemistry
From the themed collection: Recent HOT articles
Communication

A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering

We develop a ratiometric Raman probe for visualizing hydrogen sulfide in living cells as the first alkyne-based sensor for SRS microscopy.

Graphical abstract: A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering
From the themed collection: Recent HOT articles
Open Access Communication

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo.

Graphical abstract: In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
From the themed collection: Recent HOT articles
Communication

Highly sensitive and on-site NO2 SERS sensors operated under ambient conditions

This paper presents the first demonstration of highly sensitive and on-site SERS-based NO2 sensors with a detection limit of 0.1 ppm operated under ambient conditions.

Graphical abstract: Highly sensitive and on-site NO2 SERS sensors operated under ambient conditions
From the themed collection: Recent HOT articles
Communication

A new enzyme immunoassay for alpha-fetoprotein in a separate setup coupling an aluminium/Prussian blue-based self-powered electrochromic display with a digital multimeter readout

A new immunoassay was designed for the detection of disease-related biomarkers (alpha-fetoprotein, AFP, as a model), coupling an aluminium (Al)/Prussian blue-based electrochromic display with a digital multimeter readout.

Graphical abstract: A new enzyme immunoassay for alpha-fetoprotein in a separate setup coupling an aluminium/Prussian blue-based self-powered electrochromic display with a digital multimeter readout
From the themed collection: Recent HOT articles
Communication

Wettability alteration in a functional capillary tube for visual quantitative point of care testing

A quantified POCT device was designed based on wettability alteration in a capillary tube.

Graphical abstract: Wettability alteration in a functional capillary tube for visual quantitative point of care testing
From the themed collection: Recent HOT articles
Communication

A novel electrochemiluminescence biosensor based on S-doped yttrium oxide ultrathin nanosheets for the detection of anti-Dig antibodies

The mechanism of a novel electrochemiluminescence biosensor based on S-doped yttrium oxide ultrathin nanosheets for detection of anti-Dig antibodies.

Graphical abstract: A novel electrochemiluminescence biosensor based on S-doped yttrium oxide ultrathin nanosheets for the detection of anti-Dig antibodies
From the themed collection: Recent HOT articles
Communication

Molecularly imprinted nanoparticles for inhibiting ribonuclease in reverse transcriptase polymerase chain reaction

We showed that molecularly imprinted nanoparticles (nanoMIPs) could efficiently inhibit the activities of the RNase in RT-PCR reactions, demonstrating that the tailor-made nanomaterials are very promising for use in routine biological assays.

Graphical abstract: Molecularly imprinted nanoparticles for inhibiting ribonuclease in reverse transcriptase polymerase chain reaction
From the themed collection: Recent HOT articles
Communication

Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

A homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity was established.

Graphical abstract: Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules
From the themed collection: Recent HOT articles
Communication

A thumb-size electrochemical system for portable sensors

A thumb-size and precise electrochemical system is designed for sensors in size and cost sensitive applications.

Graphical abstract: A thumb-size electrochemical system for portable sensors
From the themed collection: Analyst Emerging Investigators
Communication

An ultrasensitive photoelectrochemical bioanalysis strategy for tumor markers based on the significantly enhanced signal of a bismuth oxyiodine microsphere/graphitic carbon nitride composite

An ultrasensitive PEC bioanalysis strategy was designed based on the significantly enhanced signal of BiOI/g-C3N4 and amplified signal variation of CuS NPs.

Graphical abstract: An ultrasensitive photoelectrochemical bioanalysis strategy for tumor markers based on the significantly enhanced signal of a bismuth oxyiodine microsphere/graphitic carbon nitride composite
From the themed collection: Recent HOT articles
Communication

Time-resolved visual detection of heparin by accelerated etching of gold nanorods

Plasmonic gold nanorods are promising and sensitive light scattering probes, which can reach the single particle level. Herein, we present the scattering properties of gold nanorods for time-resolved visual detection of heparin based on the rapid etching of gold nanorods under dark-field microscopy.

Graphical abstract: Time-resolved visual detection of heparin by accelerated etching of gold nanorods
From the themed collection: Recent HOT articles
Communication

Deducing disulfide patterns of cysteine-rich proteins using signature fragments produced by top-down mass spectrometry

With improved deconvolution and fragment identification strategies, we use the patterns of specific modifications of fragment ions resulted from disulfide cleavage in top-down mass spectrometry to deduce the complex disulfide patterns of cysteine-rich proteins.

Graphical abstract: Deducing disulfide patterns of cysteine-rich proteins using signature fragments produced by top-down mass spectrometry
From the themed collection: Recent HOT articles
Open Access Paper

Digital enzyme assay using attoliter droplet array

Attoliter-volume and air-sealed reactor array for fast and robust single-molecule enzyme assay.

Graphical abstract: Digital enzyme assay using attoliter droplet array
From the themed collection: Recent HOT articles
Paper

Highly sensitive detection of exosomes by SERS using gold nanostar@Raman reporter@nanoshell structures modified with a bivalent cholesterol-labeled DNA anchor

Exosomes, as important signal transmitters, play a key role in intercellular communication, especially in cancer metastasis.

Graphical abstract: Highly sensitive detection of exosomes by SERS using gold nanostar@Raman reporter@nanoshell structures modified with a bivalent cholesterol-labeled DNA anchor
From the themed collection: Recent HOT articles
Paper

Structuring polarity-inverted TBA to G-quadruplex for selective recognition of planarity of natural isoquinoline alkaloids

Selective small molecules’ planarity identification is first developed using the polarity inverted G-quadruplex as a high-performance selector.

Graphical abstract: Structuring polarity-inverted TBA to G-quadruplex for selective recognition of planarity of natural isoquinoline alkaloids
From the themed collection: Recent HOT articles
Paper

2D europium coordination polymer as a regenerable fluorescence probe for efficiently detecting fipronil

A metal organic coordination polymer based fluorescent probe was used to detect fipronil for the first time. Luminescence intensities of 1 continuously reduced with increasing concentrations of fipronil, and still showed high fluorescence intensity after four cycles.

Graphical abstract: 2D europium coordination polymer as a regenerable fluorescence probe for efficiently detecting fipronil
From the themed collection: Recent HOT articles
Paper

Two new quinoline-based regenerable fluorescent probes with AIE characteristics for selective recognition of Cu2+ in aqueous solution and test strips

Two novel highly selective quinoline-based fluorescent probes with an aggregation induced emission (AIE) feature are used for rapid analysis of Cu2+ in aqueous media and on paper strips with a fluorescence quenching mechanism.

Graphical abstract: Two new quinoline-based regenerable fluorescent probes with AIE characteristics for selective recognition of Cu2+ in aqueous solution and test strips
From the themed collection: Recent HOT articles
Paper

A reaction-based near-infrared fluorescent probe that can visualize endogenous selenocysteine in vivo in tumor-bearing mice

Endogenously generated selenocysteine in tumor-bearing mice were selectively detected by our reaction-based NIR probe for the first time.

Graphical abstract: A reaction-based near-infrared fluorescent probe that can visualize endogenous selenocysteine in vivo in tumor-bearing mice
From the themed collection: Recent HOT articles
Paper

Design of a simple paper-based colorimetric biosensor using polydiacetylene liposomes for neomycin detection

A paper-based analytical device (μPAD) combined with self-signaling polydiacetylene liposomes was developed for convenient visual neomycin detection.

Graphical abstract: Design of a simple paper-based colorimetric biosensor using polydiacetylene liposomes for neomycin detection
From the themed collection: Recent HOT articles
Paper

Primer dephosphorylation-initiated circular exponential amplification for ultrasensitive detection of alkaline phosphatase

We develop a new fluorescent method for ultrasensitive alkaline phosphatase assay based on primer dephosphorylation-initiated isothermal circular exponential amplification.

Graphical abstract: Primer dephosphorylation-initiated circular exponential amplification for ultrasensitive detection of alkaline phosphatase
From the themed collection: Recent HOT articles
Paper

Collagen formation observed from healing calvarial defects with principal component analysis of Raman scattering

Raman, along with PCA and optical techniques, helps in diagnosis of bone compositional changes during healing calvarial defects.

Graphical abstract: Collagen formation observed from healing calvarial defects with principal component analysis of Raman scattering
From the themed collection: Recent HOT articles
Paper

A colorimetric chemosensor for heptanal with selectivity over formaldehyde and acetaldehyde through synergistic interaction of hydrophobic interactions and oxime formation

Hydroxylamine-functionalized polydiacetylene was evaluated as a heptanal chemosensor with selectivity over formaldehyde and acetaldehyde.

Graphical abstract: A colorimetric chemosensor for heptanal with selectivity over formaldehyde and acetaldehyde through synergistic interaction of hydrophobic interactions and oxime formation
From the themed collection: Recent HOT articles
Paper

A simple fluorescent aptamer based assay coupled with fluorescence scanning capillary array for aflatoxin B1

AFB1 binding to a fluorescently labeled aptamer causes a fluorescence increase, and AFB1 detection is achieved by fluorescence scanning of a capillary array.

Graphical abstract: A simple fluorescent aptamer based assay coupled with fluorescence scanning capillary array for aflatoxin B1
From the themed collection: Recent HOT articles
Paper

Lateral flow assays for Ochratoxin A using metal nanoparticles: comparison of “adsorption–desorption” approach to linkage inversion assembled nano-aptasensors (LIANA)

Nano-aptamer probes were prepared and used in lateral flow colorimetric assays for the detection of Ochratoxin A (OTA).

Graphical abstract: Lateral flow assays for Ochratoxin A using metal nanoparticles: comparison of “adsorption–desorption” approach to linkage inversion assembled nano-aptasensors (LIANA)
From the themed collection: Recent HOT articles
Paper

Label-free determination of adenosine and mercury ions according to force mapping-based force-to-color variety

Force mapping can be used as a novel force-to-color sensing technique for the label-free detection of adenosine and Hg2+.

Graphical abstract: Label-free determination of adenosine and mercury ions according to force mapping-based force-to-color variety
From the themed collection: Recent HOT articles
Paper

Innovative HPTLC method with fluorescence detection for assessment of febuxostat–montelukast combination and study of their protective effects against gouty arthritis

This study was designed to evaluate the potential protective effects of montelukast, febuxostat and their combination on a model of acute gouty arthritis, and to establish a HPTLC method for determination of both drugs simultaneously.

Graphical abstract: Innovative HPTLC method with fluorescence detection for assessment of febuxostat–montelukast combination and study of their protective effects against gouty arthritis
From the themed collection: Recent HOT articles
Paper

Online monitoring of the kinetic isotope effect in chemical reactions with 1H and 19F low-field NMR spectroscopy

Real-time monitoring of the kinetic isotope effect by low-field 1H and 19F spectroscopy.

Graphical abstract: Online monitoring of the kinetic isotope effect in chemical reactions with 1H and 19F low-field NMR spectroscopy
From the themed collection: Recent HOT articles
Paper

Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor

A novel label-free BLI aptasensor was developed for the rapid and sensitive detection of nodularin-R in water.

Graphical abstract: Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor
From the themed collection: Recent HOT articles
Paper

Surface dependent enhancement in water vapor permeation through nanochannels

Transmission resistance for selective water vapor permeation through hydrophobic conduits with a varying degree of surface wettability is estimated inside a nanofluidic device.

Graphical abstract: Surface dependent enhancement in water vapor permeation through nanochannels
From the themed collection: Recent HOT articles
Open Access Paper

Reporter bacteriophage T7NLC utilizes a novel NanoLuc::CBM fusion for the ultrasensitive detection of Escherichia coli in water

Rapid detection of bacteria responsible for foodborne diseases is a growing necessity for public health.

Graphical abstract: Reporter bacteriophage T7NLC utilizes a novel NanoLuc::CBM fusion for the ultrasensitive detection of Escherichia coli in water
From the themed collection: Recent HOT articles
Paper

Raman spectroscopic analysis of the molecular composition of oral cavity squamous cell carcinoma and healthy tongue tissue

By use of a fitting algorithm with pure compound spectra, we show that the content of carbohydrates, proteins and aminoacids is the strongest discriminator between OCSCC and healthy oral tissue.

Graphical abstract: Raman spectroscopic analysis of the molecular composition of oral cavity squamous cell carcinoma and healthy tongue tissue
From the themed collection: Recent HOT articles
Paper

Au nanocluster-embedded chitosan nanocapsules as labels for the ultrasensitive fluorescence immunoassay of Escherichia coli O157:H7

Ultrasensitive fluorescence immunoassay of Escherichia coli O157:H7 is described using Au nanocluster-embedded chitosan nanocapsules as labels.

Graphical abstract: Au nanocluster-embedded chitosan nanocapsules as labels for the ultrasensitive fluorescence immunoassay of Escherichia coli O157:H7
From the themed collection: Recent HOT articles
Paper

Analysis of time-course drug response in rat cardiomyocytes cultured on a pattern of islands

Beating fluctuations of cardiomyocytes were analyzed using a scanning electrochemical microscopy-based system under a culture environment during drug stimulation.

Graphical abstract: Analysis of time-course drug response in rat cardiomyocytes cultured on a pattern of islands
From the themed collection: Recent HOT articles
Paper

Rationally designed haptens for highly sensitive monoclonal antibody-based immunoanalysis of fenhexamid

The importance of an optimum hapten design for developing highly sensitive immunoassays has been demonstrated.

Graphical abstract: Rationally designed haptens for highly sensitive monoclonal antibody-based immunoanalysis of fenhexamid
From the themed collection: Recent HOT articles
Paper

Colorimetric ultrasensitive detection of DNA based on the intensity of gold nanoparticles with dark-field microscopy

We present an ultrasensitive colorimetric nucleic acid assay based on the intensity of gold nanoparticles (Au NPs) using dark field microscopy.

Graphical abstract: Colorimetric ultrasensitive detection of DNA based on the intensity of gold nanoparticles with dark-field microscopy
From the themed collection: Recent HOT articles
Paper

Design concepts in absorbance optical systems for analytical ultracentrifugation

Analytical ultracentrifugation is a powerful technique for analyzing particles in solution, and has proved valuable for a wide range of applications in chemistry, biochemistry and material sciences for many years.

Graphical abstract: Design concepts in absorbance optical systems for analytical ultracentrifugation
From the themed collection: Recent HOT articles
Paper

Fluorescence assay for alkaline phosphatase based on ATP hydrolysis-triggered dissociation of cerium coordination polymer nanoparticles

We have developed a fluorescence assay for ALP based on ATP hydrolysis-triggered dissociation of coordination polymer nanoparticles.

Graphical abstract: Fluorescence assay for alkaline phosphatase based on ATP hydrolysis-triggered dissociation of cerium coordination polymer nanoparticles
From the themed collection: Recent HOT articles
Paper

Probing the propeller-like loops of DNA G-quadruplexes with looped-out 2-aminopurine for label-free switchable molecular sensing

We report a novel ligand-free signal readout mechanism for probing the propeller-like loops of DNA G-quadruplexes with looped-out 2-aminopurine.

Graphical abstract: Probing the propeller-like loops of DNA G-quadruplexes with looped-out 2-aminopurine for label-free switchable molecular sensing
From the themed collection: Recent HOT articles
Paper

A light-up fluorescence assay for tumor cell detection based on bifunctional split aptamers

Truncating, splitting and fusing of two aptamers for label-free and one-step fluorescence detection of tumor cells.

Graphical abstract: A light-up fluorescence assay for tumor cell detection based on bifunctional split aptamers
From the themed collection: Recent HOT articles
Paper

Thermosensitive molecularly imprinted core–shell CdTe quantum dots as a ratiometric fluorescence nanosensor for phycocyanin recognition and detection in seawater

Combining molecular imprinting, ratiometric fluorescence and a stimulus response enables the temperature-regulated sensitive detection of phycocyanin.

Graphical abstract: Thermosensitive molecularly imprinted core–shell CdTe quantum dots as a ratiometric fluorescence nanosensor for phycocyanin recognition and detection in seawater
From the themed collection: Recent HOT articles
Paper

Miniature diamond-anvil cells for FTIR-microspectroscopy of small quantities of biosamples

A small amount of biosample is mounted on a diamond anvil cell and spectra registered using simple 15× infrared objective instead of being grown on a diamond and measured by FTIR-ATR.

Graphical abstract: Miniature diamond-anvil cells for FTIR-microspectroscopy of small quantities of biosamples
From the themed collection: Recent HOT articles
Paper

Detection of exogenous substances in latent fingermarks by silver-assisted LDI imaging MS: perspectives in forensic sciences

For over one hundred years, the fingerprint has reigned as one of the most trusted pieces of forensic evidence for suspect identification. Today, modern imaging mass spectrometry technology allows to correlate molecular information to the fingerprint giving us valuable insights into a suspect lifestyle and behaviour.

Graphical abstract: Detection of exogenous substances in latent fingermarks by silver-assisted LDI imaging MS: perspectives in forensic sciences
From the themed collection: Recent HOT articles
Paper

Direct-laser-writing of three-dimensional porous graphene frameworks on indium-tin oxide for sensitive electrochemical biosensing

Direct-laser-writing of three-dimensional porous graphene frameworks on indium-tin-oxide glass towards the fabrication of a unique electrode with outstanding electrochemical performance.

Graphical abstract: Direct-laser-writing of three-dimensional porous graphene frameworks on indium-tin oxide for sensitive electrochemical biosensing
From the themed collection: Recent HOT articles
Paper

In vitro FTIR microspectroscopy analysis of primary oral squamous carcinoma cells treated with cisplatin and 5-fluorouracil: a new spectroscopic approach for studying the drug–cell interaction

In vitro FTIRM analysis of primary OSCCs treated with cisplatin and 5-fluorouracil for the drug–cell interaction.

Graphical abstract: In vitro FTIR microspectroscopy analysis of primary oral squamous carcinoma cells treated with cisplatin and 5-fluorouracil: a new spectroscopic approach for studying the drug–cell interaction
From the themed collection: Recent HOT articles
Paper

Enantioselective Raman spectroscopy (esR) for distinguishing between the enantiomers of 2-butanol

The first experimental application of enantioselective Raman (esR) spectroscopy demonstrates the discrimination of the enantiomers of 2-butanol.

Graphical abstract: Enantioselective Raman spectroscopy (esR) for distinguishing between the enantiomers of 2-butanol
From the themed collection: Recent HOT articles
Paper

Test strips based on iron(III)-impregnated alginate/polyacrylonitrile nanofibers for naked eye screening of tetracycline

A test strip for tetracycline screening was prepared using seaweed derivative alginate wrapped with polyacrylonitrile nanofibers.

Graphical abstract: Test strips based on iron(iii)-impregnated alginate/polyacrylonitrile nanofibers for naked eye screening of tetracycline
From the themed collection: Recent HOT articles
Paper

Naked-eye and electrochemical detection of isothermally amplified HOTAIR long non-coding RNA

A naked-eye, colorimetric and electrochemical detection of HOTAIR long non-coding RNA has been demonstrated.

Graphical abstract: Naked-eye and electrochemical detection of isothermally amplified HOTAIR long non-coding RNA
From the themed collection: Recent HOT articles
Paper

An improved k-nearest neighbour method to diagnose breast cancer

An algorithm of entropy weighted local-hyperplane k-nearest-neighbor is proposed for the identification of Raman spectra and is effective for cancer diagnosis.

Graphical abstract: An improved k-nearest neighbour method to diagnose breast cancer
From the themed collection: Recent HOT articles
Paper

A new photoelectrochemical biosensor for ultrasensitive determination of nucleic acids based on a three-stage cascade signal amplification strategy

Based on a “signal-on” sensing strategy and a three-stage cascade signal amplification method, an ultrasensitive photoelectrochemical biosensor has been developed for DNA detection.

Graphical abstract: A new photoelectrochemical biosensor for ultrasensitive determination of nucleic acids based on a three-stage cascade signal amplification strategy
From the themed collection: Recent HOT articles
Paper

A novel liquid chromatography detector based on a dielectric barrier discharge molecular emission spectrometer with online microwave-assisted hydrolysis for determination of dithiocarbamates

A novel detector for liquid chromatography (LC) for the determination of dithiocarbamate (DTC) fungicides is presented with a miniaturized dielectric barrier discharge–microplasma molecular emission spectrometer and an online microwave-assisted hydrolysis reactor.

Graphical abstract: A novel liquid chromatography detector based on a dielectric barrier discharge molecular emission spectrometer with online microwave-assisted hydrolysis for determination of dithiocarbamates
From the themed collection: Recent HOT articles
Paper

An improved detection limit and working range of lateral flow assays based on a mathematical model

The detection limit and working range of lateral flow assays are investigated experimentally and numerically.

Graphical abstract: An improved detection limit and working range of lateral flow assays based on a mathematical model
From the themed collection: Recent HOT articles
Paper

Lab on a tip: atomic force microscopy – photothermal infrared spectroscopy of atmospherically relevant organic/inorganic aerosol particles in the nanometer to micrometer size range

AFM-PTIR is utilized to analyze atmospherically relevant multicomponent substrate deposited aerosol particles.

Graphical abstract: Lab on a tip: atomic force microscopy – photothermal infrared spectroscopy of atmospherically relevant organic/inorganic aerosol particles in the nanometer to micrometer size range
From the themed collection: Recent HOT articles
Paper

Systematic analysis of various ionic liquids by attenuated total reflectance spectroscopy (145–450 nm) and quantum chemical calculations

Electronic absorption spectra in 140–450 nm were investigated by attenuated total reflectance spectroscopy and quantum chemical calculations.

Graphical abstract: Systematic analysis of various ionic liquids by attenuated total reflectance spectroscopy (145–450 nm) and quantum chemical calculations
From the themed collection: Recent HOT articles
Paper

Porous NiCo2O4 nanoarray-integrated binder-free 3D open electrode offers a highly efficient sensing platform for enzyme-free glucose detection

Porous binary metal oxide NiCo2O4 NWA/CC was prepared and utilized as a 3D binder-free open electrode for enzyme-free sensing with high performance.

Graphical abstract: Porous NiCo2O4 nanoarray-integrated binder-free 3D open electrode offers a highly efficient sensing platform for enzyme-free glucose detection
From the themed collection: Recent HOT articles
Paper

Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink stability and response properties.

Graphical abstract: Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel
From the themed collection: Recent HOT articles
Paper

Gene expression data and FTIR spectra provide a similar phenotypic description of breast cancer cell lines in 2D and 3D cultures

Gene expression patterns and FTIR spectral data are strongly correlated. Both identified the genotypes and phenotypes of breast cancer cell lines.

Graphical abstract: Gene expression data and FTIR spectra provide a similar phenotypic description of breast cancer cell lines in 2D and 3D cultures
From the themed collection: Recent HOT articles
Paper

Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD)

A multi-faceted site-specific quantitative N-glycoproteomics workflow was developed to probe PKM2 signaling.

Graphical abstract: Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD)
From the themed collection: Recent HOT articles
Paper

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

Aptamers selectively binding to glioblastoma multiforme cells were identified.

Graphical abstract: DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells
From the themed collection: Recent HOT articles
Paper

Highly stable protein immobilization via maleimido-thiol chemistry to monitor enzymatic activity

Combining a novel protein immobilisation method with multivariate curve resolution enables the direct observation of biocatalysis by ATR-FTIR spectroscopy.

Graphical abstract: Highly stable protein immobilization via maleimido-thiol chemistry to monitor enzymatic activity
From the themed collection: Recent HOT articles
Paper

Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)

Key rules for the design of analytical operations based on the transverse solute dispersion in paper are provided.

Graphical abstract: Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)
From the themed collection: Recent HOT articles
Paper

Electrochemical Hg2+ detection at tannic acid-gold nanoparticle modified electrodes by square wave voltammetry

We report the electrochemical sensing of Hg2+ based on tannic acid capped gold nanoparticle (AuNP@TA) complexes.

Graphical abstract: Electrochemical Hg2+ detection at tannic acid-gold nanoparticle modified electrodes by square wave voltammetry
From the themed collection: Recent HOT articles
Paper

A simple and sensitive detection of small molecule–protein interactions based on terminal protection-mediated exponential strand displacement amplification

A new strategy to detect a small molecule–protein interaction was devised based on terminal protection-mediated exponential strand displacement amplification (eSDA).

Graphical abstract: A simple and sensitive detection of small molecule–protein interactions based on terminal protection-mediated exponential strand displacement amplification
From the themed collection: Recent HOT articles
Paper

Graphene-amplified femtosensitive aptasensing of estradiol, an endocrine disruptor

Aptasensing mechanism for femtomolar detection of estradiol [E2], an endocrine disruptor.

Graphical abstract: Graphene-amplified femtosensitive aptasensing of estradiol, an endocrine disruptor
From the themed collection: Recent HOT articles
Paper

Label-free and sensitive detection of Ochratoxin A based on dsDNA-templated copper nanoparticles and exonuclease-catalyzed target recycling amplification

A sensitive method for Ochratoxin A detection was developed which combines the advantages of label-free dsDNA-templated copper nanoparticles and exonuclease-catalyzed recycling amplification.

Graphical abstract: Label-free and sensitive detection of Ochratoxin A based on dsDNA-templated copper nanoparticles and exonuclease-catalyzed target recycling amplification
From the themed collection: Recent HOT articles
Paper

Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas: improving the accuracy of trajectory method calculations

An accurate theoretical collision cross section calculation method in nitrogen was developed for reliable structural ion mobility mass spectrometry.

Graphical abstract: Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas: improving the accuracy of trajectory method calculations
From the themed collection: Recent HOT articles
Paper

First characterization of a biphasic, switch-like DNA amplification

An isothermal, high-gain DNA amplification chemistry with biphasic and switch-like properties.

Graphical abstract: First characterization of a biphasic, switch-like DNA amplification
From the themed collection: Recent HOT articles
Paper

Fluorometric detection of EGFR exon 19 deletion mutation in lung cancer cells using graphene oxide

A sensitive fluorometric detection of EGFR exon 19 deletion mutation based on probe DNA-degrading PCR and graphene oxide.

Graphical abstract: Fluorometric detection of EGFR exon 19 deletion mutation in lung cancer cells using graphene oxide
From the themed collection: Recent HOT articles
Paper

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein–protein interactions

Here protein cross-linking capillary electrophoresis is demonstrated for a wide range of protein–protein interactions including weak and multimeric oligomers.

Graphical abstract: Protein cross-linking capillary electrophoresis at increased throughput for a range of protein–protein interactions
From the themed collection: Recent HOT articles
Paper

Rosamine with pyronine-pyridinium skeleton: unique mitochondrial targetable structure for fluorescent probes

Rosamine-based probes (1a–b) with pyronine-pyridinium skeleton served as mitochondrial targetable probes for detecting independent species (H2O2 and H2S).

Graphical abstract: Rosamine with pyronine-pyridinium skeleton: unique mitochondrial targetable structure for fluorescent probes
From the themed collection: Recent HOT articles
98 items - Showing page 1 of 2

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This collection represents the top 10% of research published in Analyst. Featured articles are marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured

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