Issue 10, 2021

Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

Abstract

Integrating CRISPR–Cas12a sensors with a portable glucose meter (PGM) was developed based on the target-induced activation of the collateral cleavage activity of Cas12a. Considering the portability, low cost and facile incorporation of the PGM system with suitable Cas12a sensors to recognize many targets, the CRISPR/Cas12a-PGM system demonstrated here paves a way to further broaden the POC applications of CRISPR-based diagnostics.

Graphical abstract: Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

Supplementary files

Article information

Article type
Communication
Submitted
03 Jan 2021
Accepted
24 Mar 2021
First published
25 Mar 2021

Analyst, 2021,146, 3114-3120

Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

R. Liu, Y. He, T. Lan and J. Zhang, Analyst, 2021, 146, 3114 DOI: 10.1039/D1AN00008J

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