Jump to main content
Jump to site search

Themed collection Optical Diagnosis

23 items
Editorial

Optical diagnosis – highlighting the clinical applications of vibrational spectroscopy

Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Kathleen Gough and Frédéric Leblond.

Graphical abstract: Optical diagnosis – highlighting the clinical applications of vibrational spectroscopy
From the themed collection: Optical Diagnosis
Communication

A protocol for rapid, label-free histochemical imaging of fibrotic liver

Mid-infrared microscopy is a non-destructive, quantitative and label-free spectroscopic imaging technique that, as a result of recent instrument advancements, is now at the point of enabling high-throughput automated biochemical screening of whole histology samples.

Graphical abstract: A protocol for rapid, label-free histochemical imaging of fibrotic liver
From the themed collection: Optical Diagnosis
Open Access Paper

Probing glycosaminoglycan spectral signatures in live cells and their conditioned media by Raman microspectroscopy

GAG profiling in live cells by micro-Raman spectroscopy.

Graphical abstract: Probing glycosaminoglycan spectral signatures in live cells and their conditioned media by Raman microspectroscopy
From the themed collection: Optical Diagnosis
Paper

Towards a correlative approach for characterising single virus particles by transmission electron microscopy and nanoscale Raman spectroscopy

The morphology and structure of biological nanoparticles, such as viruses, can be efficiently analysed by transmission electron microscopy (TEM).

Graphical abstract: Towards a correlative approach for characterising single virus particles by transmission electron microscopy and nanoscale Raman spectroscopy
From the themed collection: Optical Diagnosis
Paper

Monitoring the biochemical alterations in hypertension affected salivary gland tissues using Fourier transform infrared hyperspectral imaging

FTIR imaging shows biochemical differences between salivary glands from control and hypertensive rats.

Graphical abstract: Monitoring the biochemical alterations in hypertension affected salivary gland tissues using Fourier transform infrared hyperspectral imaging
From the themed collection: Optical Diagnosis
Paper

High definition infrared chemical imaging of colorectal tissue using a Spero QCL microscope

Mid-infrared microscopy has become a key technique in the field of biomedical science and spectroscopy. In this current study, we explore the use of a QCL infrared microscope to produce high definition, high throughput chemical images useful for the screening of biopsied colorectal tissue.

Graphical abstract: High definition infrared chemical imaging of colorectal tissue using a Spero QCL microscope
From the themed collection: Optical Diagnosis
Paper

Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients

High throughput Raman spectroscopy method for rapid and accurate diagnosis of prostate cancer using liquid plasma samples.

Graphical abstract: Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients
From the themed collection: Optical Diagnosis
Paper

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning

S-FTIR and Raman microspectroscopies identify spectral markers of sensitivity/resistance to nilotinib in leukaemia cell clones.

Graphical abstract: Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning
From the themed collection: Optical Diagnosis
Paper

Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties

Non-destructive near infrared spectroscopic data can be utilized for assessment of compositional and mechanical properties of engineered cartilage.

Graphical abstract: Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties
From the themed collection: Optical Diagnosis
Paper

Ultra-filtration of human serum for improved quantitative analysis of low molecular weight biomarkers using ATR-IR spectroscopy

Monitoring of changes in the concentrations of the low molecular weight constituents enhanced by abundant proteins depletion.

Graphical abstract: Ultra-filtration of human serum for improved quantitative analysis of low molecular weight biomarkers using ATR-IR spectroscopy
From the themed collection: Optical Diagnosis
Paper

Digital de-waxing on FTIR images

This paper presents a procedure that digitally neutralizes the contribution of paraffin to FTIR hyperspectral images.

Graphical abstract: Digital de-waxing on FTIR images
From the themed collection: Optical Diagnosis
Open Access Paper

Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation

Infrared spectral histopathology has shown great promise as an important diagnostic tool, with the potential to complement current pathological methods.

Graphical abstract: Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation
From the themed collection: Recent Open Access Articles
Paper

The effect of common anticoagulants in detection and quantification of malaria parasitemia in human red blood cells by ATR-FTIR spectroscopy

Total Reflectance Infrared Spectroscopy (ATR-FTIR) has the potential to become a new diagnostic tool for malaria and other diseases.

Graphical abstract: The effect of common anticoagulants in detection and quantification of malaria parasitemia in human red blood cells by ATR-FTIR spectroscopy
From the themed collection: Optical Diagnosis
Paper

Infrared imaging of high density protein arrays

We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling.

Graphical abstract: Infrared imaging of high density protein arrays
From the themed collection: Recent HOT articles
Paper

HTS-FTIR spectroscopy allows the classification of polyphenols according to their differential effects on the MDA-MB-231 breast cancer cell line

FTIR-based classification of the effect of polyphenols on a breast cancer cell line.

Graphical abstract: HTS-FTIR spectroscopy allows the classification of polyphenols according to their differential effects on the MDA-MB-231 breast cancer cell line
From the themed collection: Optical Diagnosis
Paper

SIproc: an open-source biomedical data processing platform for large hyperspectral images

There has recently been significant interest within the vibrational spectroscopy community to apply quantitative spectroscopic imaging techniques to histology and clinical diagnosis.

Graphical abstract: SIproc: an open-source biomedical data processing platform for large hyperspectral images
From the themed collection: Optical Diagnosis
Paper

Optical properties of porcine dermis in the mid-infrared absorption band of glucose

Mid-infrared absorption and scattering properties of porcine dermis are quantified using quantum cascade laser-based goniometry.

Graphical abstract: Optical properties of porcine dermis in the mid-infrared absorption band of glucose
From the themed collection: Optical Diagnosis
Paper

Early diagnosis of Alzheimer's disease using infrared spectroscopy of isolated blood samples followed by multivariate analyses

A simple blood test for the diagnosis of Alzheimer's disease using FTIR microscopy.

Graphical abstract: Early diagnosis of Alzheimer's disease using infrared spectroscopy of isolated blood samples followed by multivariate analyses
From the themed collection: Optical Diagnosis
Paper

Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy

The great capability of virtual staining for label-free classification of colon cancer tissue has been demonstrated via Raman spectral imaging.

Graphical abstract: Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy
From the themed collection: Optical Diagnosis
Paper

Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus

The diagnostic performance of Raman spectroscopy for differentiating lichen sclerosus from other vulval conditions in fresh vulval biopsies is demonstrated.

Graphical abstract: Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus
From the themed collection: Optical Diagnosis
Paper

Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification

A filter system to perform in vivo Raman spectroscopy measurements under microscope lighting for seamless integration into the surgical workflow.

Graphical abstract: Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification
From the themed collection: Optical Diagnosis
Paper

Label-free spectroscopic characterization of live liver sinusoidal endothelial cells (LSECs) isolated from the murine liver

Imaging with the use of Raman spectroscopy enables the characterization and distinction of live cells that were freshly isolated from murine livers.

Graphical abstract: Label-free spectroscopic characterization of live liver sinusoidal endothelial cells (LSECs) isolated from the murine liver
From the themed collection: Optical Diagnosis
Paper

Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus

Barrett's oesophagus (BE) is a premalignant condition that can progress to oesophageal adenocarcinoma. Fourier transform infrared (FTIR) mapping can be used to identify neoplastic Barrett's with high accuracy in a clinically applicable timeframe.

Graphical abstract: Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus
From the themed collection: Optical Diagnosis
23 items

About this collection

This collection of papers highlights work from the SPEC 2016 conference on Optical Diagnosis held in Montreal, Canada, 26-30 June 2016. Guest Edited by Fred Leblond and Kathy Gough. 

Spotlight

Advertisements