Themed collection Journal of Materials Chemistry B Recent Review Articles

Engineering the metabolism of microbes has allowed simultaneous co-production of functional small molecules and biopolymers.

Sex differences in biology are observed at multiple different length scales and across organ systems.

Fluidics are enabling new possibilities in bioelectronic medicine and research.

Water content derived from the environment is as an important a variable as temperature for affecting the conductivity and for understanding the charge transport mechanisms within conductive biomaterials as well as bioelectronic devices.

We summarise the superiorities of nanomotors over traditional nanomedicines, state-of-the-art applications and current challenges of using nanomotors in the biomedical field.

Carbon-based nanostructures as drug carriers have attracted a great deal of interest over the past half of the century because of their promising chemical, thermal, physical, optical, mechanical, electrical properties, and their structural diversity.

Organic luminogens possess excellent photonic features that are essential for biomedical applications.

Hematopoietic stem cell (HSC) transplantation provides an effective platform for the treatment of hematological disorders.

This article outlines the construction strategies of multi-component carrier-free nanodrugs based on the fundamental properties of their constituent substances (organic/inorganic and hydrophilic/hydrophobic), and prospects for the development.

Metal–organic frameworks (MOFs) have attracted considerable attention as emerging nanomaterials.

ADMSC-Exo-miRNAs as therapeutic strategies for wound healing.

This review paper introduced a novel 3B-based classification (Biofunctionality, Bioactivity, Biostability), which mainly governs native body response, to provide a comprehensive overview to examine the in vitro and in vivo responses of additively manufactured Ti64 implants.

In recent years, the research of metal ions has become more extensive in bone tissue engineering. We review the mechanism and application of metal ions in the treatment of different pathological types of bone defects in bone tissue engineering.

In this review, the development, mechanism and applications of antimicrobial surfaces with polymer-based modification strategies are highlighted.

This paper summarizes the different assembly strategies adopted in recent years, the effects of driving forces on self-assembly, and the application of porphyrin–peptides, and briefly discusses the challenges and prospects for future research.

Organic-nanoparticles (NPs) delivery systems for crossing the blood–brain barrier.

Chondroitin sulfate (CS), a natural anionic mucopolysaccharide, belonging to the glycosaminoglycan family, has been in the limelight for its unique properties in diverse biomedical applications.

2D nanomaterials show great potential in bone tissue engineering due to their unique physical and chemical surface properties.

Essential oils (EOs) can act as natural biocide agents when introduced in renewable/bio-based polymers. The nature of EOs influences the mechanical properties and the antibacterial activities of the final bio-based materials.

Metal-porphyrinic frameworks find multiple important applications in agriculture based on their rich properties including semi-conductivity, strong absorption of visible light and fluorescence, porosity, and photosensitization of singlet oxygen.

This review aims to analyze how the paper material offers unique and polyvalent properties to bridge together multiple uses of nanomaterials and develop electrochemical biosensors for application in the biomedical field.

The importance of diagnosis and in situ monitoring of lesion regions and transportation of bioactive molecules has a pivotal effect on successful treatment, reducing side effects, and increasing the chances of survival in the case of diseases.

We summarized the mechanisms of cellular response to piezoelectronic electrons and the applications of piezoelectronic electrons in cell regulation and tissue regeneration according to the types of cells and tissues.

This review summarizes the regulations of liquid–liquid phase separation involving fused in sarcoma protein (FUS) by physical stimuli, biochemical modulators and protein structural modifications.

An overview of strategies from designing high-quality rare-earth-doped nanoparticles to bioimaging in the NIR region.

Primary materials for biodegradable bioelectronics: conductive materials blended with biodegradable components, conjugated polymers with biodegradable moieties, naturally derived conjugated biopolymers, and aqueously dissolvable inorganic materials.

Microfluidics has been applied to fabricate high-performance functional materials contributing to all physiological stages of wound healing. The advances of microfluidic-based functional materials for wound healing have been summarized.

Bioactive hydrogels exhibit physicochemical-responsive activities to repair infarcted myocardium and restore the cardiac function after myocardial infarction.

PEI-based cancer vaccines increase the cellular uptake of antigens and adjuvants by dendritic cells and promote activation and antigen cross-presentation to effectively cross-prime antigen-specific T cells and B cells for robust antitumor immunity.

The field of porous biomaterials has grown rapidly over the past decades.

Herein, we review the fluorescent probes for the detection of H₂S levels and dynamics in living cells and organisms and discuss the design methods, response mechanisms, and applications.

Oxygenation therapies for wound healing.

This review introduces the roles of key ferroptosis-regulating molecules in the progression of drug resistance and reviews the design of ferroptosis-inducing strategies based on nanotechnology for overcoming drug resistance.

The CRISPR system has attracted significant attention due to its great potential in tumor therapy.

Herein, recent advances in nanomaterials integrated with 3D printing technologies are summarized to inform the reader about the cutting-edge technology in the development of advanced 3D-printed structures for biomedical applications.

This review highlights the PX-based DNA nanostructures in biological systems, dynamic systems, and biomedical contexts.

Strategies for reducing CRS in CAR-T cells capitalize on the specificity between CAR-T cells, cytokines, and their receptors, the role of macrophages in cytokine release, and genetic constructs to ablate CAR-T function reversibly and irreversibly.

Mitochondria play a critical role in cell growth and metabolism.

Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection.

Tumor microenvironment-activated longitudinal or transverse relaxation tuning shows highly promising applications. Smart MRI contrast agents exhibit high potential for tracking cancer progression and evolution and monitoring treatment process.

This review comprehensively covers the extraction, characterization, functionalization and biomedical applications of bacterial outer membrane vesicles (OMVs).

Biomaterials demonstrate great potential in the treatment of psoriasis.

We are in the evolution of continuous monitoring of neural activity with non-invasive wearable EEGs. The development of hydrogel electrodes technology is important for home-use systems for long-term EEG monitoring and diagnostics of disease.

This paper systematically reviews recent studies on nanomedicines targeting sPLA2 overexpression in many inflammatory diseases and various types of cancer during the past few years.

Chitosan has been widely used to assemble different types of oral colon-targeted delivery systems, which attract great attention in the delivery of polyphenols to the colon for the treatment of colon and non-colon diseases.

We summarize the recent research progress concerning conjugated polymer-based luminescent probes for ratiometric detection of biomolecules.

This review mainly summarizes the research progress of cell membrane extraction and coating technology, with an emphasis on the treatment of cancer with cell membrane-engineered nanoparticles from various sources.

This review summarizes the recent research progress in various cell therapies and surveys the biomaterials developed to assist cell-based therapeutics for wide applications in diverse disease treatments.

This review covers the design principles of hemostatic biomaterials based on biochemical and mechanical mechanisms, and discusses the remaining challenges and immediate opportunities to manage non-compressible hemorrhage with biomaterials.

This review summarizes the development of reduction-responsive disulfide-crosslinked PCys²-based nanoparticles through one-pot polymerization, post-polymerization modification, and post-polymerization self-assembly for biomedical applications.

By integrating multiple types of guidance cues, electrospun nanofiber scaffolds can be used to manipulate cell behaviors and thus facilitate soft tissue regeneration, including nerves, skin, heart, blood vessels, and cornea.

Thioether-based reactive oxygen species (ROS) responsive polymers and polypeptides, with the ability to self-assemble in aqueous media and disassemble or being transformed in the presence of ROS, are ideal candidates for target biomedical therapies.

Magnetomechanical force for therapeutic applications.

This review provides the recent progress, intrinsic interactions between structures and bioactive performances, current limitations and future directions of bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management.

With highly favorable properties such as enormous internal surface areas, high porosity and large flexibility, metal–organic frameworks (MOFs) have emerged as promising materials for applications such as gas storage and separation, catalysis, wastewater filtration, etc.

Supramolecular self-assembly offers the possibility for modulating nanostructures and reprogramming immunological properties, paving the way for enhanced cancer immunotherapy.

Smart biomaterials have been rapidly advancing ever since the concept of tissue engineering was proposed.

This review aims to summarize different drug delivery vehicles and delivery processes to provide ideas for effective cancer therapy.

This review aims to highlight the recent advances, key limitations, and future directions of membrane-fusogenic biomimetic particles for biomedical applications.

Recent advances in the preparation of high-performance artificial enzymes based on MIPs and molecularly imprinted nanozymes.

This review summarized the recent advances of protein imprinted polymers (PIPs) focused on the imprinting methods and highlighted applications.

Semiconducting polymer dots (Pdots) are novel fluorescent probes with relatively high brightness, fast emission rate, and excellent photostability. This review systematically summarizes their applications for in vitro biosensing.

The stimuli-responsive material properties of arylboronate ester-based materials originate from the dynamics and reactivity of arylboronic acids.

This review summarizes the advances in bone regeneration of electrospun nanofibers, focusing their compositions, structures, functions, and fabrication technologies, which provide guidance for design of electrospun nanofibers for bone regeneration.

In this review, we have summarised and reviewed the current matrix materials used for the preparation of MNs in light of the five aspects. In addition, we conclude with a summary of the MN products used on the market and their applications.

As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation.

Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic with diverse potential for engineering biomedical hydrogels.

The functional modifications of polymers for mucoadhesive drug delivery and mucosal transport mechanism.

Stimulus responsive composite hydrogels combines with ready-to-use particles to form multi-scale delivery system. After solidification in vivo, the biological agents slowly released induce stem cells to differentiate into IVD tissue.

This review focuses on the design and application of MOF-based drugs against lung diseases, and discusses the possibility of preparing MOF-based inhalable formulations and the challenges and opportunities of MOFs in clinical applications targeting lung diseases.