Issue 35, 2022

Recent advances in protein-imprinted polymers: synthesis, applications and challenges

Abstract

The molecular imprinting technique (MIT), also described as the “lock to key” method, has been demonstrated as an effective tool for the creation of synthetic polymers with antibody-like sites to specifically recognize target molecules. To date, most successful molecular imprinting researches were limited to small molecules (<1500 Da); biomacromolecule (especially protein) imprinting remains a serious challenge due to their large size, chemical and structural complexity, and environmental instability. Nevertheless, protein imprinting has achieved some significant breakthroughs in imprinting methods and applications over the past decade. Some special protein-imprinted materials with outstanding properties have been developed and exhibited excellent potential in several advanced fields such as separation and purification, proteomics, biomarker detection, bioimaging and therapy. In this review, we critically and comprehensively surveyed the recent advances in protein imprinting, particularly emphasizing the significant progress in imprinting methods and highlighted applications. Finally, we summarize the major challenges remaining in protein imprinting and propose its development direction in the near future.

Graphical abstract: Recent advances in protein-imprinted polymers: synthesis, applications and challenges

Article information

Article type
Review Article
Submitted
07 feb 2022
Accepted
14 apr 2022
First published
19 apr 2022

J. Mater. Chem. B, 2022,10, 6571-6589

Recent advances in protein-imprinted polymers: synthesis, applications and challenges

Y. He and Z. Lin, J. Mater. Chem. B, 2022, 10, 6571 DOI: 10.1039/D2TB00273F

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