Issue 37, 2022

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Abstract

Due to their inherent and tunable biomechanical and biochemical performances, bioactive hydrogels based on polysaccharides and peptides have shown attractive potential for wound management. In this review, the recent progress of bioactive hydrogels prepared by polysaccharides and peptides for soft tissue wound management is overviewed. Meanwhile, we focus on the elaboration of the relationship between chemical structures and inherent bioactive functions of polysaccharides and peptides, as well as the strategies that are taken for achieving multiple wound repairing effects including hemostasis, adhesion, wound contraction and closure, anti-bacteria, anti-oxidation, immunomodulation, molecule delivery, etc. Some innovative and important works are well introduced as well. In the end, current study limitations, clinical unmet needs, and future directions are discussed.

Graphical abstract: Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Article information

Article type
Review Article
Submitted
20 mar 2022
Accepted
13 apr 2022
First published
20 apr 2022

J. Mater. Chem. B, 2022,10, 7148-7160

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

L. Wu, Y. He, H. Mao and Z. Gu, J. Mater. Chem. B, 2022, 10, 7148 DOI: 10.1039/D2TB00591C

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