Issue 31, 2022

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Abstract

As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral administration is critical for the treatment of IBD. Unfortunately, it is difficult to target the bowel located in the GI tract due to multiple physical barriers. The unique physicochemical properties of nanoparticle-based drug delivery systems (DDSs) and their enhanced permeability and retention effects in the inflamed bowel, render nanomedicines to be used to implement precise drug delivery at diseased sites in IBD therapy. In this review, we described the pathophysiological features of IBD, and designed strategies to exploit these features for intestinal targeting. In addition, we introduced the types of currently developed nano-targeted carriers, including synthetic nanoparticle-based and emerging naturally derived nanoparticles (e.g., extracellular vesicles and plant-derived nanoparticles). Moreover, recent developments in targeted oral nanoparticles for IBD therapy were also highlighted. Finally, we presented challenges associated with nanotechnology and potential directions for future IBD treatment.

Graphical abstract: Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Article information

Article type
Review Article
Submitted
07 jun 2022
Accepted
14 jul 2022
First published
18 jul 2022

J. Mater. Chem. B, 2022,10, 5853-5872

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D. Li, M. Yang, H. Xu, M. Zhu, Y. Zhang, C. Tian, Y. Nie, J. Wang, Y. Liang, J. Yao and L. Wang, J. Mater. Chem. B, 2022, 10, 5853 DOI: 10.1039/D2TB01190E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements