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Themed collection 2019 Journal of Materials Chemistry B HOT Papers

44 items
Accepted Manuscript - Review Article

Fundamentals and Introductory of Cross-seeding of Amyloid Proteins

Review Article

Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects

This review provides a comprehensive overview of biomechanical studies on biomaterial degradation and co-cultured cells as well as valuable biomechanical ideas on how to design or optimize cell biomaterial co-culture system.

Graphical abstract: Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects
Review Article

Nanomaterial-based SERS sensing technology for biomedical application

Over the past few years, nanomaterial-based surface-enhanced Raman scattering (SERS) detection has emerged as a new exciting field in which theoretical and experimental studies of the structure and function of nanomaterials have become a focus.

Graphical abstract: Nanomaterial-based SERS sensing technology for biomedical application
Review Article

Versatile fluorescent probes for near-infrared imaging of amyloid-β species in Alzheimer's disease mouse model

This review comprehensively discussed the recent progress in the development of NIR fluorescent probes for amyloid-β imaging in vivo.

Graphical abstract: Versatile fluorescent probes for near-infrared imaging of amyloid-β species in Alzheimer's disease mouse model
Review Article

Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates

Light-responsive liposomes are considered nowadays as one of the most promising nanoparticulate systems for the delivery and release of an active pharmaceutical ingredient (API) in a spatio-temporal manner.

Graphical abstract: Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates
Review Article

Functional nanomaterials with unique enzyme-like characteristics for sensing applications

We highlight the recent developments in functional nanomaterials with unique enzyme-like characteristics for sensing applications.

Graphical abstract: Functional nanomaterials with unique enzyme-like characteristics for sensing applications
Communication

Equipment-free and visualized biosensor for transcription factor rapid assay based on dopamine-functionalized cellulose paper

Dopamine-functionalized cellulose paper with low cost, portable, and disposable features was applied for an equipment-free and naked-eye detection of transduction factor based on the enzyme-assisted signal amplification/transduction reaction.

Graphical abstract: Equipment-free and visualized biosensor for transcription factor rapid assay based on dopamine-functionalized cellulose paper
Communication

Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

A new highly efficient targeting drug delivery vehicle based on diselenium-containing ultrathin polymer nanocapsules was designed and prepared.

Graphical abstract: Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect
Communication

Versatile antifouling coatings based on self-assembled oligopeptides for engineering and biological materials

The existence of nonspecific protein adsorption often results in significant challenges for microfluidic devices and laboratory cultureware used in biological experiments.

Graphical abstract: Versatile antifouling coatings based on self-assembled oligopeptides for engineering and biological materials
Communication

Thermo- and photo-responsive composite hydrogels with programmed deformations

Composite hydrogels were fabricated by photolithographic polymerization to form a non-responsive gel and subsequent thermal polymerization to form a dual-responsive gel. These composite gels with heterogeneous structures showed programmed deformations upon heating or light irradiation.

Graphical abstract: Thermo- and photo-responsive composite hydrogels with programmed deformations
Communication

Design of a star-like hyperbranched polymer having hydrophilic arms for anti-biofouling coating

A simple method for anti-biofouling coating based on a star-like hyperbranched polymer having hydrophilic arms.

Graphical abstract: Design of a star-like hyperbranched polymer having hydrophilic arms for anti-biofouling coating
Paper

A magnetically modified black phosphorus nanosheet-based heparin delivery platform for preventing DVT accurately

A new heparin targeting delivery platform was developed based on iron oxide (Fe3O4) nanoparticles and polyethyleneimine (PEI) functionalized black phosphorus nanosheets (BP NSs).

Graphical abstract: A magnetically modified black phosphorus nanosheet-based heparin delivery platform for preventing DVT accurately
Accepted Manuscript - Paper

Fenton-reaction-stimulative Nanoparticles Decorated with Reactive-oxygen-species (ROS)-responsive Molecular Switch for ROS Amplification and Triple Negative Breast Cancer Therapy

Paper

Influence of pore architectures of silk fibroin/collagen composite scaffolds on the regeneration of osteochondral defects in vivo

The aligned scaffolds facilitate migration of endogenous reparative cells, leading to better regeneration of osteochondral defects.

Graphical abstract: Influence of pore architectures of silk fibroin/collagen composite scaffolds on the regeneration of osteochondral defects in vivo
Paper

D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

Two D–A polymers with good NIR-II fluorescence, photoacoustic and photothermal properties were designed and synthesized.

Graphical abstract: D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties
Paper

A selective cascade reaction-based probe for colorimetric and ratiometric fluorescence detection of benzoyl peroxide in food and living cells

A colorimetric and ratiometric fluorescent probe (Cou-BPO) was prepared for food analysis and cell imaging; it showed high selectivity, sensitivity, visible and fast response towards BPO via a selective oxidation cleavage-induced cascade reaction.

Graphical abstract: A selective cascade reaction-based probe for colorimetric and ratiometric fluorescence detection of benzoyl peroxide in food and living cells
Paper

Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy

A smart nanoplatform with doxorubicin (DOX) and simvastatin (SV) was fabricated by encapsulating both drugs in a polyphenol-based polymer for chemotherapy and MRI/PET imaging.

Graphical abstract: Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy
Paper

Two-isophorone fluorophore-based design of a ratiometric fluorescent probe and its application in the sensing of biothiols

A newly designed ratiometric fluorescent probe is applied in the sensing of biothiols.

Graphical abstract: Two-isophorone fluorophore-based design of a ratiometric fluorescent probe and its application in the sensing of biothiols
Paper

A surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration

A surface-engineered NIR light-responsive actuator has been presented for manipulating collective cell migration by activating mechanical signal transduction in live cells.

Graphical abstract: A surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration
Paper

Sodium butyrate-modified sulfonated polyetheretherketone modulates macrophage behavior and shows enhanced antibacterial and osteogenic functions during implant-associated infections

Prevention of implant-associated infections and insufficient bone tissue integration is critical to exploit the immunomodulatory properties and antibacterial effects of implant materials, which have attracted considerable attention.

Graphical abstract: Sodium butyrate-modified sulfonated polyetheretherketone modulates macrophage behavior and shows enhanced antibacterial and osteogenic functions during implant-associated infections
Paper

Polyelectrolyte complexation via viscoelastic phase separation results in tough and self-recovering porous hydrogels

Polyelectrolyte complexation is utilized to create bulk, porous hydrogels with high toughness and self-recovery due to reversible ionic associations.

Graphical abstract: Polyelectrolyte complexation via viscoelastic phase separation results in tough and self-recovering porous hydrogels
Paper

Dual drug-paired polyprodrug nanotheranostics reverse multidrug resistant cancers via mild photothermal-cocktail chemotherapy

A dual drug-paired polyprodrug nanotheranostic PDCN25-CDDP was constructed for the combination therapy PT–CCT to combat multidrug resistant cancers, achieving complete MCF-7/ADR and OVCAR-3/DDP tumor ablation for 30 days.

Graphical abstract: Dual drug-paired polyprodrug nanotheranostics reverse multidrug resistant cancers via mild photothermal-cocktail chemotherapy
Paper

Intelligent protein-coated bismuth sulfide and manganese oxide nanocomposites obtained by biomineralization for multimodal imaging-guided enhanced tumor therapy

Radiotherapy (RT) has been used clinically to overcome cancer in recent decades.

Graphical abstract: Intelligent protein-coated bismuth sulfide and manganese oxide nanocomposites obtained by biomineralization for multimodal imaging-guided enhanced tumor therapy
Paper

Harnessing combinational phototherapy via post-synthetic PpIX conjugation on nanoscale metal–organic frameworks

Novel photoactive metal–organic framework nanoparticles were developed using a facile post-synthetic conjugation method to achieve tunable combinational PDT and PTT.

Graphical abstract: Harnessing combinational phototherapy via post-synthetic PpIX conjugation on nanoscale metal–organic frameworks
Open Access Paper

Zinc phthalocyanine activated by conventional indoor light makes a highly efficient antimicrobial material from regular cellulose

A phthalocyanine-cellulose material quickly inactivates drug-resistant microbes under indoor light.

Graphical abstract: Zinc phthalocyanine activated by conventional indoor light makes a highly efficient antimicrobial material from regular cellulose
Paper

Rate-controlled nano-layered assembly mechanism of melamine-induced melamine–uric acid stones and its inhibition and elimination methods

The formation of kidney stones induced by melamine is a rate-controlled nano-scale supramolecular layered assembly process.

Graphical abstract: Rate-controlled nano-layered assembly mechanism of melamine-induced melamine–uric acid stones and its inhibition and elimination methods
Paper

2-Dicyanomethylenethiazole based NIR absorbing organic nanoparticles for photothermal therapy and photoacoustic imaging

TPTHM NPs are candidates for PAI/PTT agents due to their NIR absorption, good biocompatibility, high photostability and photothermal conversion efficiency (38%).

Graphical abstract: 2-Dicyanomethylenethiazole based NIR absorbing organic nanoparticles for photothermal therapy and photoacoustic imaging
Paper

BODIPY derivatives as light-induced free radical generators for hypoxic cancer treatment

NBDP can self-assemble into nanoparticles (NBDP NPs), which could be internalized by cells via endocytosis. After being irradiated with an 808 nm laser, the BODIPY unit could convert photons into heat and further initiates the production of alkyl radicals. The generated tumor hyperthermia and alkyl radicals synergistically kill cancer cells.

Graphical abstract: BODIPY derivatives as light-induced free radical generators for hypoxic cancer treatment
Paper

Hemocompatibility investigation and improvement of near-infrared persistent luminescent nanoparticle ZnGa2O4:Cr3+ by surface PEGylation

ZnGa2O4:Cr3+ hemocompatibility was systematically investigated from the aspects of hemolysis, erythrocyte morphology, coagulation and complement system activation, and greatly improved by surface PEGylation.

Graphical abstract: Hemocompatibility investigation and improvement of near-infrared persistent luminescent nanoparticle ZnGa2O4:Cr3+ by surface PEGylation
Paper

Constructing peptide-based artificial hydrolases with customized selectivity

The substrate selectivity of peptide-based artificial enzymes can be customized by combining molecularly imprinted polymers as binding sites with peptide nanofibers as catalytic moieties.

Graphical abstract: Constructing peptide-based artificial hydrolases with customized selectivity
Paper

Self-adhesive photothermal hydrogel films for solar-light assisted wound healing

Self-adhesive photothermal hydrogel films can adhere to skin wound and convert solar light into heat, warming up the wound locally and promoting wound repair.

Graphical abstract: Self-adhesive photothermal hydrogel films for solar-light assisted wound healing
Paper

A dual-aptamer-based biosensor for specific detection of breast cancer biomarker HER2 via flower-like nanozymes and DNA nanostructures

A dual-aptamer electrochemical biosensor based on flower-like nanozymes and DNA nanostructures was fabricated for detection of breast cancer biomarker HER2.

Graphical abstract: A dual-aptamer-based biosensor for specific detection of breast cancer biomarker HER2 via flower-like nanozymes and DNA nanostructures
Paper

A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy

We have developed a HDAC6-selective inhibitor, SelSA, which can be utilized as a target for the detection and treatment of ERα(+) breast cancer and TNBC. The biodistribution study showed that SelSA can specifically target the breast tumor and display potent antitumor effects in vivo. This result will help to better improve the treatment efficacy against breast cancer.

Graphical abstract: A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy
Paper

Highly sensitive detection of antibodies in a soft bioactive three-dimensional bioorthogonal hydrogel

This three-dimensional detection method of antibodies offers a high sensitivity and good biomolecule stability for new biosensing devices.

Graphical abstract: Highly sensitive detection of antibodies in a soft bioactive three-dimensional bioorthogonal hydrogel
Paper

Nitrogen doped carbon dots: mechanism investigation and their application for label free CA125 analysis

Nitrogen-doped CDs (N-CDs) were firstly prepared by using pear juice as the carbon source and ethanediamine as a nitrogen doping precursor with a microwave assisted pyrolysis technique. Based on the fluorescence recovery induced by competitive adsorption and desorption, a label-free “turn on” fluorescence assay with high sensitivity and selectivity was proposed for the analysis of CA125.

Graphical abstract: Nitrogen doped carbon dots: mechanism investigation and their application for label free CA125 analysis
Paper

Depletion of protein thiols and the accumulation of oxidized thioredoxin in Parkinsonism disclosed by a red-emitting and environment-sensitive probe

Protein sulfhydryl groups play a vital role in maintaining cellular redox homeostasis and protein functions and have attracted increasing interests for the selective detection of protein thiols over low-molecular-weight thiols (LMWTs).

Graphical abstract: Depletion of protein thiols and the accumulation of oxidized thioredoxin in Parkinsonism disclosed by a red-emitting and environment-sensitive probe
Paper

Detection of hypochlorous acid fluctuation via a selective near-infrared fluorescent probe in living cells and in vivo under hypoxic stress

The near-infrared fluorescent probe Cy-HOCl for monitoring HOCl in living cells, zebrafish and mice under hypoxic stress.

Graphical abstract: Detection of hypochlorous acid fluctuation via a selective near-infrared fluorescent probe in living cells and in vivo under hypoxic stress
Paper

An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

An AIE-active probe of Cur-N-BF2 is developed for light-up detection of Aβ fibrils and plaques, inhibition of Aβ fibrillation, disassembly of preformed Aβ fibrils, and protection of neuronal cells.

Graphical abstract: An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells
Paper

Light-driven ultrasensitive self-powered cytosensing of circulating tumor cells via integration of biofuel cells and a photoelectrochemical strategy

A light-driven self-powered cytosensing platform was developed via integration of biofuel cells and a photoelectrochemical strategy for the detection of circulating tumor cells.

Graphical abstract: Light-driven ultrasensitive self-powered cytosensing of circulating tumor cells via integration of biofuel cells and a photoelectrochemical strategy
Paper

A fluorogenic probe based on chelation–hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models

Developing efficient methods for real-time detection of Zn2+ level in biological systems is highly relevant to improve our understanding of the role of Zn2+ in the progression of Parkinson's disease (PD).

Graphical abstract: A fluorogenic probe based on chelation–hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models
Paper

Ordered mesoporous carbon-covered carbonized silk fabrics for flexible electrochemical dopamine detection

Flexible dopamine sensors were fabricated with ordered mesoporous carbon-covered carbonized silk fabrics (OMC/CSFs) as the working electrodes, which exhibited high sensitivity, good selectivity, a large linear detection range of 0.2–80 μM, and a low limit detection of 0.11 μM.

Graphical abstract: Ordered mesoporous carbon-covered carbonized silk fabrics for flexible electrochemical dopamine detection
Paper

Multipronged design of theranostic nanovehicles with endogenous and exogenous stimuli-responsiveness for precise cancer therapy

Multifunctional nanovehicle with pH and NIR light stimuli-responsiveness for fluorescence imaging and chemo/photothermal combination antitumor therapy.

Graphical abstract: Multipronged design of theranostic nanovehicles with endogenous and exogenous stimuli-responsiveness for precise cancer therapy
Paper

A universal photoelectrochemical biosensor for dual microRNA detection based on two CdTe nanocomposites

A universal photoelectrochemical biosensor for dual microRNA detection has been successfully developed.

Graphical abstract: A universal photoelectrochemical biosensor for dual microRNA detection based on two CdTe nanocomposites
Paper

A multifunctional polymeric gene delivery system for circumventing biological barriers

Crucial light-controlled-ROS and pH-stimulus-responsive functionalities are tailored into a triblock copolymer for manufacture of gene delivery vehicles.

Graphical abstract: A multifunctional polymeric gene delivery system for circumventing biological barriers
44 items

About this collection

This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2019 marked as HOT, as recommended by referees.  Congratulations to all the authors whose articles are featured!

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