Bodipy Derivatives as Light-induced Free Radical Generator for Hypoxic Cancer Treatment
In photodynamic therapy, the hypoxic condition greatly impedes the treatment efficacy due to the high dependence on oxygen for the generation of toxic reactive oxygen species (ROS). Accordingly, it is imperative to develop novel oxygen-independent therapeutic strategy. Herein, the novel organic self-assembly of distyryl-diethylamine-borondipyrromethene nanoparticles (NBDP NPs) were designed to generate oxygen-independent alkyl under near-infrared light (NIR) irradiation, in which borondipyrromethene (BODIPY) unit with high photothermal conversion efficiency 54 % act as alkyl radical initiator. The experiments in vitro have proved NBDP NPs can effectively generate alkyl radical in hypoxic condition and induce apoptosis. The weak acidic environment in lysosome can further accelerate to generate alkyl radicals. The obtained data in vivo also verify the generated free alkyl radicals can inhibit the growth of tumor. This combination of photothermal therapy (PTT) with free radical outlines a new platform for hypoxic cancer therapy.
- This article is part of the themed collection: 2019 Journal of Materials Chemistry B HOT Papers