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Self-adhesive photothermal hydrogel film for solar-light assisted wound healing

Abstract

Hydrogel-based dressings can provide a moist environment for the wound, which has been proven to be beneficial for wound healing. However, it still remains a big challenge to prepare effective hydrogel dressings in a facile yet robust manner. Herein, a photo-initiated polymerization method is employed to develop a photothermal hydrogel film with self-adhesive property for accelerated wound healing under solar light irradiation. Such hydrogel films are obtained by taking advantages of excellent adhesion of bioinspired polydopamine (PDA) and great photothermal conversion capability of reduced graphene oxide (rGO) upon solar light irradiation. The formed photothermal hydrogel film could adhere to the wound and convert solar light into heat, warming up the wound locally. The localized temperature enhancement significantly promotes wound healing by reducing inflammatory response, enhancing re-epithelialization, angiogenesis, and collagen deposition, presumably correlated to the increased expressions of transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor-A (VEGF-A). This finding demonstrates the great potential of the photothermal hydrogel film for wound healing in clinical or daily applications.

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Publication details

The article was received on 10 Mar 2019, accepted on 23 Apr 2019 and first published on 01 May 2019


Article type: Paper
DOI: 10.1039/C9TB00481E
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Self-adhesive photothermal hydrogel film for solar-light assisted wound healing

    Y. Gao, H. Du, Z. Xie, M. Li, J. Zhu, J. Xu, L. Zhang, J. Tao and J. Zhu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB00481E

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