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D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

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Abstract

NIR-II fluorescence imaging has great potential in diagnosis, but the quantum efficiency of contrast agents is an urgent problem to be solved. We synthesized two new multifunctional polymers, P-TT and P-DPP, with a tetrahedral C (sp3) and branched alkyl chains in the main chain, which were beneficial to obtain high quantum efficiency. P-TT and P-DPP showed absorption peaks of 686 nm and 763 nm, respectively, and fluorescence emission peaks of 1071 nm and 1066 nm, respectively. The photothermal effect of P-DPP can reach 52 °C, and the quantum yield reaches 1.5%, which was three times higher than that of nanotube fluorophores (quantum yield 0.4%). P-DPP is used for stable fluorescence imaging of blood vessels and photoacoustic imaging of nude mice, and successfully applied to phototherapy of nude mouse tumours.

Graphical abstract: D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

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Publication details

The article was received on 15 Jun 2019, accepted on 16 Sep 2019 and first published on 20 Sep 2019


Article type: Paper
DOI: 10.1039/C9TB01196J
J. Mater. Chem. B, 2019, Advance Article

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    D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

    Y. Zhu, C. Gu, Y. Miao, B. Yu, Y. Shen and H. Cong, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01196J

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