Themed collection Chemical Biology
The right touch: design of artificial antigen-presenting cells to stimulate the immune system
In this review we discuss the rapid developments on artificial structures meant to manipulate the immune system.
Inteins: nature's gift to protein chemists
Inteins are a unique class of auto-processing domains with numerous applications in protein engineering and chemical biology.
Realizing the promise of chemical glycobiology
This review highlights recent advances and identifies the challenges and opportunities in chemical glycobiology, an emerging subfield of chemical biology.
glycoprotein vaccines: current status and future directions
We highlight current glycovaccines in the clinic and derive principles for the construction of the next generation of synthetically defined glycoconjugate vaccines.
On the reactivity and selectivity of donor
glycosides in glycochemistry and glycobiology: trapped covalent intermediates
Chemistry meets biology: parallels between covalent intermediates in chemical glycosylation and enzymatic glycoside hydrolysis reactions.
Chemical biology toolkit for exploring
protein kinase catalyzed phosphorylation reactions
Protein kinases catalyzed phosphorylations of peptide and protein substrates.
Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology
The trimethyl lock provides unmatched attributes as a trigger for the release of small molecules by an enzymatic, chemical, or photolytic process.
Hydrogenases and oxygen
We summarize the current picture of oxygen-induced inhibition of the different classes of hydrogenases and discuss possible avenues that might lead to tailored oxygen-robust enzyme variants.
Glucose conjugation for the specific targeting and treatment of cancer
This minireview discusses current progress in, and important considerations for, the emerging field of glycoconjugated anticancer therapeutics.
Enzyme inhibition by metal complexes: concepts, strategies and applications
Metal complexes are increasingly being used to inhibit enzymes.
Dressed for success – applying chemistry to modulate aptamer functionality
Chemical modifications modulate aptamer functionality and help to assert their full application potential.
Interactions of anticancer Pt compounds with
proteins: an overlooked topic in medicinal inorganic chemistry?
An overview of the studies concerning the interactions of platinum anticancer agents with proteins/peptides is provided.
DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides
The pyrazole and salen ligandosides, when combined, are able to create stable multi-copper ion complexing DNA duplex structures in a cooperative fashion.
Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover
A RNA triggered chemical peptidyl transfer reaction leads to a cytotoxic peptide conjugate that requires turnover in RNA for bioactivity.
Functionalised staple linkages for modulating the cellular activity of stapled peptides
A divergent synthetic strategy for generating helical p53 peptides bearing functionalised staple linkages, allowing for efficient optimisation of cellular activity.
Chemoenzymatic exchange of phosphopantetheine on protein and peptide
Evaluation of new acyl carrier protein hydrolase homologs from proteobacteria and cyanobacteria reveals significant variation in substrate selectivity and kinetics.
Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
Structure-dependent anticancer activity of metallo-helices, novel interactions with potential drug targets, and evidence of an apoptotic mechanism are presented.
Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers
Dityrosine-linked Aβ dimers have been synthesized and display decreased rates of fibrilization and increased neuronal cell toxicity compared with the corresponding monomeric peptides.
Specific recognition of DNA depurination by a luminescent terbium(III) complex
A terbium(III) complex exhibits sensitive luminescence response to purine bases in DNA, which can be used to recognize DNA depurination as a selective time-resolved luminescence probe.
Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy
MR Imaging probes for NMDA receptors on a hybrid NSC-34 cell line show relaxation enhancements; the receptors have been visualised by microscopy and the specificity and reversibility of binding demonstrated.
cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
A cyclic peptide inhibitor of the CtBP transcription repressor, discovered using a genetically encoded HTS platform, is used to link upregulated glycolytic flux to cell-cycle regulation in tumors.
Chemical fidelity of an RNA polymerase ribozyme
We challenge a polymerase ribozyme with an array of nucleotide variants to assess its tolerance of substrate heterogeneity. We uncover specificity determinants, and describe the implications for primordial RNA replication.
hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules
Primary carbons of propane and ethane are hydroxylated under high-pressure conditions of the alkanes (0.5 MPa) by wild-type P450BM3.
Remodeling a β-
We apply the Rosetta algorithm to repack the hydrophobic core of a β-peptide bundle while retaining both structure and stability.
inhibitors to probe the active site microenvironment of fatty acid amide hydrolase
To test the hypothesis that FAAH recruits its hydrophobic substrates directly from the cellular lipid bilayer, we have created clickable, photoreactive inhibitors that enable exploration of the enzyme's active site microenvironment in native cellular membranes.
A dendrimer-based platform for simultaneous dual
fluorescence imaging of hydrogen peroxide and pH gradients produced in living cells
We present a modular dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients in the phagosomes of RAW 264.7 macrophages during immune insult.
About this collection
Looking for the best articles at the chemistry-biology interface? Associate Editors Professor Ben Davis and Professor Tom Muir, have picked some of their favourite articles recently published in Chemical Science. The collection showcases some of the great research papers and reviews published in Chemical Science in the areas of chemical biology and bioinorganic chemistry.