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Issue 7, 2014
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Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

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Abstract

We describe a RNA-programmed peptidyl transfer reaction, which triggers the formation of a cytotoxic, cell permeant 14-mer peptide–PNA conjugate from inactive fragments. Turnover in the RNA template is required to evoke the bioactivity. HeLa cells enabled the read-out of the reaction, which proceeded rapidly when it was performed on matched RNA templates.

Graphical abstract: Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

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Supplementary files

Article information


Submitted
27 Jan 2014
Accepted
18 Mar 2014
First published
21 Mar 2014

Chem. Sci., 2014,5, 2850-2854
Article type
Edge Article
Author version available

Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

O. Vázquez and O. Seitz, Chem. Sci., 2014, 5, 2850
DOI: 10.1039/C4SC00299G

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