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Issue 8, 2013
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Synthetically defined glycoprotein vaccines: current status and future directions

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Abstract

Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

Graphical abstract: Synthetically defined glycoprotein vaccines: current status and future directions

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Publication details

The article was received on 30 Mar 2013, accepted on 03 May 2013 and first published on 07 May 2013


Article type: Perspective
DOI: 10.1039/C3SC50862E
Citation: Chem. Sci., 2013,4, 2995-3008
  • Open access: Creative Commons BY license
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    Synthetically defined glycoprotein vaccines: current status and future directions

    R. Adamo, A. Nilo, B. Castagner, O. Boutureira, F. Berti and G. J. L. Bernardes, Chem. Sci., 2013, 4, 2995
    DOI: 10.1039/C3SC50862E

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