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Themed collection Editor’s choice – Andrei Yudin

10 items
Open Access Edge Article

Nickel-catalyzed C–N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling

The reductive cross coupling of pyridinium salts derived from readily available primary alkyl amines with aryl halides has been achieved under mild reaction conditions using a nickel catalyst.

Graphical abstract: Nickel-catalyzed C–N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines

Chiral phosphoric acid catalyzed the formal [4+2]-cycloaddition of 2-benzothiazolimines with enecarbamates to provide benzothiazolopyrimidines with up to 99% yield and >99% ee.

Graphical abstract: Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines
From the themed collection: 2019 ChemSci Pick of the Week Collection
Open Access Edge Article

Dinuclear manganese alkoxide complexes as catalysts for C–N bond cleavage of simple tertiary N,N-dialkylamides to give esters

Amide bonds are stable due to the resonance between the nitrogen lone pair and the carbonyl moiety, and therefore the chemical transformation of amides, especially tertiary amides, involving C–N bond fission is considered one of the most difficult organic reactions, unavoidably requiring harsh reaction conditions and strong acids or bases.

Graphical abstract: Dinuclear manganese alkoxide complexes as catalysts for C–N bond cleavage of simple tertiary N,N-dialkylamides to give esters
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Catalytic β C–H amination via an imidate radical relay

An iodine-catalyzed strategy for β C–H amination of alcohols is enabled by a chemo-, regio-, and stereo-selective H-atom transfer mechanism.

Graphical abstract: Catalytic β C–H amination via an imidate radical relay
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Macrocyclisation of small peptides enabled by oxetane incorporation

Head-to-tail peptide macrocyclisations are significantly improved, as measured by isolated yields, reaction rates and product distribution, by substitution of one of the backbone amide CO bonds with an oxetane ring.

Graphical abstract: Macrocyclisation of small peptides enabled by oxetane incorporation
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Asymmetric synthesis of (−)-naltrexone

The asymmetric synthesis of (−)-naltrexone was achieved by a Rh(I)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation.

Graphical abstract: Asymmetric synthesis of (−)-naltrexone
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Using stereoretention for the synthesis of E-macrocycles with ruthenium-based olefin metathesis catalysts

The synthesis of E-macrocycles is achieved using stereoretentive, Ru-based olefin metathesis catalysts supported by dithiolate ligands.

Graphical abstract: Using stereoretention for the synthesis of E-macrocycles with ruthenium-based olefin metathesis catalysts
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions

A new thiadiazole-forming macrocyclization reaction enables the one-pot synthesis of cyclic β-peptide libraries from readily accessible building blocks without additional reagents.

Graphical abstract: Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Mechanistic insights into boron-catalysed direct amidation reactions

The generally accepted monoacyloxyboron mechanism of boron-catalysed direct amidation is brought into question in this study, and new alternatives are proposed.

Graphical abstract: Mechanistic insights into boron-catalysed direct amidation reactions
From the themed collection: Editor’s choice – Andrei Yudin
Open Access Edge Article

Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

A formal aromaticity transfer reaction between phenols and pyrrolines/indolines has been developed: a redox- and atom-efficient method to synthesize N-cyclohexylpyrroles/indoles.

Graphical abstract: Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines
From the themed collection: Editor’s choice – Andrei Yudin
10 items

About this collection

In 2019, Chemical Science welcomed Professor Andrei Yudin to the journal as an Associate Editor, handling papers in the areas of organic synthesis, transition metal catalysis, peptide preparation and macrocyclisation.

Andrei has looked back over recently published Chemical Science papers and has selected some outstanding articles on the theme of catalysis and synthetic methodology. We hope you enjoy reading through this selection.

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