Themed collection Direct C-H Functionalization in Method Development and Late Stage Functionalization
Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry
This review describes the advances in the design and application of novel artificial metalloenzymes in C–H activation reactions.
Late stage functionalization of heterocycles using hypervalent iodine(III) reagents
Iodine(III) reagents represent a powerful tool for the late-stage functionalization of a variety of heterocycles through a range of transformations.
Visible light-mediated organophotocatalyzed C–H bond functionalization reactions
This review provides a current overview of the recent developments in the visible light mediated organophotocatalyzed C–H bond functionalization methodologies.
Recent advances in metal-free aerobic C–H activation
An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors.
Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation
A convenient ruthenium-catalysed N-directed C–H monoarylation of arylpyrazoles with a good selectivity of up to 96% is reported.
Metal-free late-stage C(sp2)–H functionalization of N-aryl amines with various sodium salts
Metal-free consecutive C(sp2)–X (X = Cl, Br, S, N) bond formations of N-aryl amines (cyclic, fused, carbamate, and aminium radicals) were achieved under mild conditions using PIFA and simple nonharmful sodium salts.
Mild C–H functionalization of alkanes catalyzed by bioinspired copper(II) cores
Three new copper(II) coordination compounds with aminoalcohol and carboxylate type ligands were self-assembled, fully characterized, and applied as efficient homogeneous catalysts for the mild oxidation and carboxylation of saturated hydrocarbons.
Ruthenium(II)-catalysed selective C(sp2)–H bond benzoxylation of biologically appealing N-arylisoindolinones
A general site- and regio-selective aromatic C–H bond benzoxylation reaction using biologically-relevant isoindolinones as weak directing groups has been developed.
A computational study on the identity of the active catalyst structure for Ru(II) carboxylate assisted C–H activation in acetonitrile
Density Functional Theory (DFT) calculations using a consistent methodology accounting for solvation, dispersion and thermal effects have been used to study C–H activation of the simple directing group substrate 2-phenylpyridine (a-H).
Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
DDQ and IBX are effective SET oxidants of N-aryl-protected and unprotected THIQs. Mannich and Strecker type functionalizations ensued in an overall CDC reaction.
Synthesis of fluorenyl alcohols via cooperative palladium/norbornene catalysis
Catalytic synthesis of fluorenols by synchronization of two stoichiometric reactions: (a) Pd(II)-mediated oxidation of alcohols to ketones and (b) Pd(0)/norbornene-catalyzed reaction of aryl iodides with ortho-bromoacetophenones.
Manganese(III) acetate-mediated direct C(sp2)–H-sulfonylation of enamides with sodium and lithium sulfinates
A Mn(OAc)3 mediated oxidative C(sp2)–H sulfonylation of enamides and encarbamates with sodium and lithium sulfinates is reported.
Late-stage C–H amination of abietane diterpenoids
Application of Rh(II)-catalyzed C–H amination reactions allows the selective late-stage diversification of abietane diterpenoids.
Investigations of the generality of quaternary ammonium salts as alkylating agents in direct C–H alkylation reactions: solid alternatives for gaseous olefins
C–H alkylation reactions using short chain olefins as alkylating agents could be operationally simplified on the lab scale by using quaternary ammonium salts as precursors for these gaseous reagents.
Ru(II)-Catalysed synthesis of (1H)-isothiochromenes by oxidative coupling of benzylthioethers with internal alkynes
(1H)-Isothiochromenes have been prepared by Ru-catalysed oxidative coupling of benzylthioethers with internal alkynes.