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Themed collection Direct C-H Functionalization in Method Development and Late Stage Functionalization

15 items
Open Access Review Article

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

This review describes the advances in the design and application of novel artificial metalloenzymes in C–H activation reactions.

Graphical abstract: Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Late stage functionalization of heterocycles using hypervalent iodine(III) reagents

Iodine(III) reagents represent a powerful tool for the late-stage functionalization of a variety of heterocycles through a range of transformations.

Graphical abstract: Late stage functionalization of heterocycles using hypervalent iodine(iii) reagents
From the themed collection: Synthetic methodology in OBC
Review Article

Visible light-mediated organophotocatalyzed C–H bond functionalization reactions

This review provides a current overview of the recent developments in the visible light mediated organophotocatalyzed C–H bond functionalization methodologies.

Graphical abstract: Visible light-mediated organophotocatalyzed C–H bond functionalization reactions
Open Access Review Article

Recent advances in metal-free aerobic C–H activation

An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors.

Graphical abstract: Recent advances in metal-free aerobic C–H activation
From the themed collection: Synthetic methodology in OBC
Communication

Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation

A convenient ruthenium-catalysed N-directed C–H monoarylation of arylpyrazoles with a good selectivity of up to 96% is reported.

Graphical abstract: Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation
Paper

Metal-free late-stage C(sp2)–H functionalization of N-aryl amines with various sodium salts

Metal-free consecutive C(sp2)–X (X = Cl, Br, S, N) bond formations of N-aryl amines (cyclic, fused, carbamate, and aminium radicals) were achieved under mild conditions using PIFA and simple nonharmful sodium salts.

Graphical abstract: Metal-free late-stage C(sp2)–H functionalization of N-aryl amines with various sodium salts
From the themed collection: Synthetic methodology in OBC
Paper

Mild C–H functionalization of alkanes catalyzed by bioinspired copper(II) cores

Three new copper(II) coordination compounds with aminoalcohol and carboxylate type ligands were self-assembled, fully characterized, and applied as efficient homogeneous catalysts for the mild oxidation and carboxylation of saturated hydrocarbons.

Graphical abstract: Mild C–H functionalization of alkanes catalyzed by bioinspired copper(ii) cores
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Ruthenium(II)-catalysed selective C(sp2)–H bond benzoxylation of biologically appealing N-arylisoindolinones

A general site- and regio-selective aromatic C–H bond benzoxylation reaction using biologically-relevant isoindolinones as weak directing groups has been developed.

Graphical abstract: Ruthenium(ii)-catalysed selective C(sp2)–H bond benzoxylation of biologically appealing N-arylisoindolinones
From the themed collection: Synthetic methodology in OBC
Open Access Paper

A computational study on the identity of the active catalyst structure for Ru(II) carboxylate assisted C–H activation in acetonitrile

Density Functional Theory (DFT) calculations using a consistent methodology accounting for solvation, dispersion and thermal effects have been used to study C–H activation of the simple directing group substrate 2-phenylpyridine (a-H).

Graphical abstract: A computational study on the identity of the active catalyst structure for Ru(ii) carboxylate assisted C–H activation in acetonitrile
Paper

Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions

DDQ and IBX are effective SET oxidants of N-aryl-protected and unprotected THIQs. Mannich and Strecker type functionalizations ensued in an overall CDC reaction.

Graphical abstract: Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of fluorenyl alcohols via cooperative palladium/norbornene catalysis

Catalytic synthesis of fluorenols by synchronization of two stoichiometric reactions: (a) Pd(II)-mediated oxidation of alcohols to ketones and (b) Pd(0)/norbornene-catalyzed reaction of aryl iodides with ortho-bromoacetophenones.

Graphical abstract: Synthesis of fluorenyl alcohols via cooperative palladium/norbornene catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Manganese(III) acetate-mediated direct C(sp2)–H-sulfonylation of enamides with sodium and lithium sulfinates

A Mn(OAc)3 mediated oxidative C(sp2)–H sulfonylation of enamides and encarbamates with sodium and lithium sulfinates is reported.

Graphical abstract: Manganese(iii) acetate-mediated direct C(sp2)–H-sulfonylation of enamides with sodium and lithium sulfinates
From the themed collection: Synthetic methodology in OBC
Paper

Late-stage C–H amination of abietane diterpenoids

Application of Rh(II)-catalyzed C–H amination reactions allows the selective late-stage diversification of abietane diterpenoids.

Graphical abstract: Late-stage C–H amination of abietane diterpenoids
From the themed collection: Synthetic methodology in OBC
Open Access Paper

Investigations of the generality of quaternary ammonium salts as alkylating agents in direct C–H alkylation reactions: solid alternatives for gaseous olefins

C–H alkylation reactions using short chain olefins as alkylating agents could be operationally simplified on the lab scale by using quaternary ammonium salts as precursors for these gaseous reagents.

Graphical abstract: Investigations of the generality of quaternary ammonium salts as alkylating agents in direct C–H alkylation reactions: solid alternatives for gaseous olefins
From the themed collection: Synthetic methodology in OBC
Paper

Ru(II)-Catalysed synthesis of (1H)-isothiochromenes by oxidative coupling of benzylthioethers with internal alkynes

(1H)-Isothiochromenes have been prepared by Ru-catalysed oxidative coupling of benzylthioethers with internal alkynes.

Graphical abstract: Ru(ii)-Catalysed synthesis of (1H)-isothiochromenes by oxidative coupling of benzylthioethers with internal alkynes
From the themed collection: Synthetic methodology in OBC
15 items

About this collection

This themed collection, Guest Edited by Professor Michael Schnürch, is dedicated to demonstrating the broadness of C-H functionalization, including method development, mechanistic and computational studies and late stage functionalization of relevant molecules such as bioactive compounds or organic materials.
Articles in this themed collection will be added below as soon as possible after they are published.
Please return to this page frequently to see the collection grow.

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