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Themed collection Horizons Community Board Themed Collection – Nanobiomedicine

19 items
Editorial

Horizons Community Board Collection – Nanobiomedicine

A themed collection on nanobiomedicine, guest edited by Nanoscale Horizons Community Board Member Chandra Kumar Dixit and Materials Horizons Community Board Member Christopher M. Proctor.

Graphical abstract: Horizons Community Board Collection – Nanobiomedicine
Minireview

DePEGylation strategies to increase cancer nanomedicine efficacy

PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.

Graphical abstract: DePEGylation strategies to increase cancer nanomedicine efficacy
From the themed collection: Recent Review Articles
Minireview

Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview

Complex antibacterial mechanisms of graphene oxide and carbon dots.

Graphical abstract: Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview
From the themed collection: Recent Review Articles
Review Article

Carbon-based nanomaterials as an emerging platform for theranostics

Carbon-based nanomaterials emerge as promising platforms for theranostic applications in disease treatment and tissue repair.

Graphical abstract: Carbon-based nanomaterials as an emerging platform for theranostics
From the themed collection: Recent Review Articles
Review Article

Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

This review discusses the recent advances and design principles for dynamic and cell-responsive hydrogels – biomaterials that respond to locally produced stimuli in and around cells or tissues without external influence.

Graphical abstract: Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration
From the themed collection: Recent Review Articles
Communication

3D quantum theranosomes: a new direction for label-free theranostics

Quantum-scale materials offer great potential in the field of cancer theranostics.

Graphical abstract: 3D quantum theranosomes: a new direction for label-free theranostics
Communication

Hydrogel nanotubes with ice helices as exotic nanostructures for diabetic wound healing

Hydrogel nanotubes with ice helices entrapped within their internal conduits are a promising material for diabetic wound healing.

Graphical abstract: Hydrogel nanotubes with ice helices as exotic nanostructures for diabetic wound healing
Open Access Communication

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

A self-regulated dynamic nanohybrid that can sensitively respond to hyperglycemic microenvironment is developed. The nanohybrid with a core/shell structure is produced through a single-step microfluidics nanoprecipitation method, where drugs-loaded porous silicon (PSi) nanoparticles are encapsulated by H2O2 responsive polymeric matrix.

Graphical abstract: Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing
From the themed collection: Recent Open Access Articles
Communication

Ferrous-cysteine–phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy

Chelating strategy and electron shuttle armed nanoagent for killing cancer cells at both an acidic and neutral pH with high CDT efficiency.

Graphical abstract: Ferrous-cysteine–phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy
Communication

Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

Graphical abstract: Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy
Communication

A single-step multi-level supramolecular system for cancer sonotheranostics

A multi-level supramolecular system produced by single-step Fe3+-mediated ionic crosslinking self-assembly can overcome the critical issues of current sonodynamic therapy (SDT) and address the need to monitor therapeutic effects in vivo with a non-invasive approach.

Graphical abstract: A single-step multi-level supramolecular system for cancer sonotheranostics
Communication

Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors

Blockage of autophagic flux by nanodiamonds induces apoptosis in hypoxic tumor cells with minimal toxicity to normal tissues and enhances the effects of anti-angiogenic therapy.

Graphical abstract: Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors
Communication

Vitamin metal–organic framework-laden microfibers from microfluidics for wound healing

Vitamin MOF-laden microfibers with alginate shells and copper- or zinc-vitamin framework cores are controllably generated for improving tissue wound healing.

Graphical abstract: Vitamin metal–organic framework-laden microfibers from microfluidics for wound healing
Open Access Communication

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

An immunological tissue engineering scaffold is fabricated using anti-CD40 antibody grafted in electrospun fibers for inducing cancer cell apoptosis, activating immune response and promoting healthy tissue regeneration.

Graphical abstract: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
From the themed collection: Recent Open Access Articles
Communication

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

We report a novel highly crystalline MOF, featuring hydroxyl-decorated channels, capable of distinctly organizing guest organic molecules within its pores.

Graphical abstract: Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes
Communication

A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms

Lipid-polymer hybrid nanoparticle enhances antibiotic efficacy through localised, sustained delivery to bacterial biofilms.

Graphical abstract: A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms
Open Access Communication

Fully degradable protein nanocarriers by orthogonal photoclick tetrazole–ene chemistry for the encapsulation and release

Tetrazole–ene click chemistry was used to prepare fully biodegradable protein nanocarriers with high drug encapsulation and enzymatically-triggered intracellular release.

Graphical abstract: Fully degradable protein nanocarriers by orthogonal photoclick tetrazole–ene chemistry for the encapsulation and release
From the themed collection: Recent Open Access Articles
Communication

Primary microglia maintain their capacity to function despite internalisation and intracellular loading with carbon nanotubes

When internalised in microglia, functionalised carbon nanotubes did not alter viability, induce inflammation or damage phagocytosis and migration abilities.

Graphical abstract: Primary microglia maintain their capacity to function despite internalisation and intracellular loading with carbon nanotubes
Communication

Assembly of hepatitis E vaccine by ‘in situ’ growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination

Vaccine-based immunotherapy plays an integral role in the development of present and future clinical therapies.

Graphical abstract: Assembly of hepatitis E vaccine by ‘in situ’ growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination
19 items

About this collection

Guest Edited by Chandra Kumar Dixit, Qiagen Sciences and Nanoscale Horizons Community Board, and Christopher Proctor, University of Cambridge and Materials Horizons Community Board.

Advancements in nanotechnology are impacting biology and medicine. In this themed collection we are compiling some noteworthy articles in the areas related to targeted delivery, vaccine, diagnostics, wound healing, and self-healing scaffolds & materials. Theranostics, which is a new branch specifically dealing with point-of-care, involves diagnostics and therapy in a single agent. Carbon-based materials are proving to be effective agents in this quest as indicated by Kapil Patel et al. in their research published in Materials Horizons (2018). Anand et al. (2019) emphasized in their review article the potential of carbon-based nanomaterials as antimicrobial agents. Scaffolds and matrices based on nanomaterials, as illustrated through the research works of Yu et al. (2018, Materials Horizons), Singh et al. (2018, Materials Horizons), Ooi (2017, Materials Horizons), and Liu (2018, Materials Horizons) have shown tremendous potential in surgery, wound healing, controlled release skin patches etc.  Given how all these materials show potential in their respective fields, it will be important to see how these will shape the future of biomedicine.  We hope that the readers find this themed collection informative and useful.

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