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Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

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Abstract

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Graphical abstract: Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

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Publication details

The article was received on 14 Sep 2018, accepted on 31 Oct 2018 and first published on 31 Oct 2018


Article type: Communication
DOI: 10.1039/C8MH01145A
Citation: Mater. Horiz., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

    Z. Liu, Y. Li, W. Li, W. Lian, M. Kemell, S. Hietala, P. Figueiredo, L. Li, E. Mäkilä, M. Ma, J. Salonen, J. T. Hirvonen, D. Liu, H. Zhang, X. Deng and H. A. Santos, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C8MH01145A

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