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An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

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Abstract

Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(L-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.

Graphical abstract: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

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Publication details

The article was received on 14 Jun 2018, accepted on 15 Aug 2018 and first published on 16 Aug 2018


Article type: Communication
DOI: 10.1039/C8MH00704G
Citation: Mater. Horiz., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

    X. Liu, H. Zhang, R. Cheng, Y. Gu, Y. Yin, Z. Sun, G. Pan, Z. Deng, H. Yang, L. Deng, W. Cui, H. A. Santos and Q. Shi, Mater. Horiz., 2018, Advance Article , DOI: 10.1039/C8MH00704G

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