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Issue 6, 2018
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An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

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Abstract

Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(L-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.

Graphical abstract: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

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Supplementary files

Article information


Submitted
14 Jun 2018
Accepted
15 Aug 2018
First published
16 Aug 2018

This article is Open Access

Mater. Horiz., 2018,5, 1082-1091
Article type
Communication

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

X. Liu, H. Zhang, R. Cheng, Y. Gu, Y. Yin, Z. Sun, G. Pan, Z. Deng, H. Yang, L. Deng, W. Cui, H. A. Santos and Q. Shi, Mater. Horiz., 2018, 5, 1082
DOI: 10.1039/C8MH00704G

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