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Themed collection Antimicrobial Resistance

23 items
Editorial

The global antibiotic research and development partnership (GARDP): researching and developing new antibiotics to meet global public health needs

Graphical abstract: The global antibiotic research and development partnership (GARDP): researching and developing new antibiotics to meet global public health needs
From the themed collection: Antimicrobial Resistance
Review Article

On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome

Targeting the T3SS injectisome using the anti-virulence strategy offers an alternative to antibiotic therapeutic approaches when dealing with resistance.

Graphical abstract: On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome
From the themed collection: Antimicrobial Resistance
Review Article

Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance

Mechanisms of antifolate resistance in bacterial and mammalian cells.

Graphical abstract: Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance
From the themed collection: Antimicrobial Resistance
Accepted Manuscript - Review Article

Drug-resistance in Mycobacterium tuberculosis: where we stand

From the themed collection: Antimicrobial Resistance
Review Article

Inhibiting bacterial secretion systems in the fight against antibiotic resistance

The search for new ammunition to combat antibiotic resistance has uncovered diverse inhibitors of the bacterial type IV secretion system.

Graphical abstract: Inhibiting bacterial secretion systems in the fight against antibiotic resistance
From the themed collection: Antimicrobial Resistance
Review Article

Gasdermin D (GSDMD) as a new target for the treatment of infection

Inhibition of pyroptosis through targeting the activation or pore-formation of GSDMD.

Graphical abstract: Gasdermin D (GSDMD) as a new target for the treatment of infection
From the themed collection: Antimicrobial Resistance
Review Article

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

To push back the growing tide of antibacterial resistance the discovery and development of new antibiotics is a must.

Graphical abstract: The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry
From the themed collection: Antimicrobial Resistance
Review Article

Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance

Biofilms are linked to resistance development in the ESKAPE pathogens. This perspective summarizes several strategies for affecting iron homeostasis that have been implicated in biofilm inhibition.

Graphical abstract: Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance
From the themed collection: Antimicrobial Resistance
Review Article

Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype

Staphylococcus aureus (S. aureus) is an asymptomatic colonizer of 30% of all human beings. It is also the most dangerous of all Staphylococcal bacteria.

Graphical abstract: Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype
From the themed collection: Antimicrobial Resistance
Research Article

Novel zafirlukast derivatives exhibit selective antibacterial activity against Porphyromonas gingivalis

Eleven new zafirlukast derivatives selective and bactericidal against Porphyromonas gingivalis.

Graphical abstract: Novel zafirlukast derivatives exhibit selective antibacterial activity against Porphyromonas gingivalis
From the themed collection: Antimicrobial Resistance
Open Access Research Article

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

Fluorescent probes derived from the fluoroquinolone antibiotic ciprofloxacin were synthesised using a Cu(I)-catalysed azide–alkyne cycloaddition (CuAAC) to link a ciprofloxacin azide derivative with alkyne-substituted green and blue fluorophores.

Graphical abstract: Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux
From the themed collection: Antimicrobial Resistance
Open Access Research Article

Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential

Compounds 1 and 2 disrupt M. tuberculosis membrane potential and demonstrate bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer.

Graphical abstract: Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential
From the themed collection: Antimicrobial Resistance
Research Article

Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives

We describe the synthesis and evaluation of 4′-subsituted netilmicin derivatives by selective functionalization at the 4′-position of the endocyclic enolether function.

Graphical abstract: Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives
From the themed collection: Antimicrobial Resistance
Research Article

Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases

N-Aryl urea derivatives were synthesized and some showed activity against mycobacterial hydrolases while others showed antimicrobial activity against mycobacterial species.

Graphical abstract: Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases
From the themed collection: Antimicrobial Resistance
Research Article

Synthetic studies on the reverse antibiotic natural products, the nybomycins

We report a new scalable and robust synthetic route to the nybomycin natural products and the activity of novel analogues of this family.

Graphical abstract: Synthetic studies on the reverse antibiotic natural products, the nybomycins
From the themed collection: Antimicrobial Resistance
Research Article

Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box

Iridium based antimicrobial agents have shown efficacy against S. aureus, including MRSA, and appear to be safe in mice.

Graphical abstract: Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box
From the themed collection: Antimicrobial Resistance
Research Article

Eradicating uropathogenic Escherichia coli biofilms with a ciprofloxacin–dinitroxide conjugate

Biofilm-related UTIs are problematic infectious diseases worldwide; here we have developed a novel ciprofloxacin–dinitroxide conjugate with potent UPEC biofilm-eradication activity.

Graphical abstract: Eradicating uropathogenic Escherichia coli biofilms with a ciprofloxacin–dinitroxide conjugate
From the themed collection: Antimicrobial Resistance
Research Article

Rapid kill assessment of an N-arylated NH125 analogue against drug-resistant microorganisms

N-Arylated NH125 analogue 1 rapidly eradicates a diverse panel of drug-resistant bacteria and fungi (≥99.9% kill in 1 to 10 minutes).

Graphical abstract: Rapid kill assessment of an N-arylated NH125 analogue against drug-resistant microorganisms
From the themed collection: Antimicrobial Resistance
Research Article

Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity

We describe a facile synthesis of saccharocin from apramycin by regioselective tetra-azidation and stereospecific oxidative deamination of the amino group.

Graphical abstract: Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity
From the themed collection: Antimicrobial Resistance
Research Article

Polybasic peptide–levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria

To address the rising threat of multidrug-resistant (MDR) bacteria, new therapeutic strategies must be developed.

Graphical abstract: Polybasic peptide–levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria
From the themed collection: Antimicrobial Resistance
Research Article

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

Biofilm formation by mycobacteria can lead to enhanced antibiotic tolerance.

Graphical abstract: Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation
From the themed collection: Antimicrobial Resistance
Open Access Research Article

‘Second-generation’ 1,2,3-triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation

This study details the design, synthesis and bioassay of ‘click’ peptidomimetic compounds which inhibit the adherence of P. gingivalis to S. gordonii, a primary step toward pathogenic colonization of the subgingival pocket.

Graphical abstract: ‘Second-generation’ 1,2,3-triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation
From the themed collection: Antimicrobial Resistance
Research Article

Structure–activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA)

MIC of oxacillin against S. aureus (MRSA252 strain) reduced from 256 μg mL−1 to 2 μg mL−1.

Graphical abstract: Structure–activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA)
From the themed collection: Antimicrobial Resistance
23 items

About this collection

This themed collection, Guest Edited by Professor Sylvie Garneau-Tsodikova, displays the cutting edge research being carried out globally in the field of antimicrobial resistance. The scope of the collection is broad and encompasses various areas related to antimicrobial (fungi, bacteria, and viruses) drug discovery and development, as well as research towards understanding the mechanism of resistance. 
Articles in this themed collection will be added below as soon as possible after they are published.
Please return to this page frequently to see the collection grow.

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