Themed collection Antimicrobial Resistance

Where do we stand in our fight against antimicrobial resistance?

The quinolone antibiotics arose in the early 1960s, with the first examples possessing a narrow-spectrum activity with unfavorable pharmacokinetic properties.

DHDPS represents a novel enzyme target for the development of new antibiotics to combat multidrug resistance.

Targeting the T3SS injectisome using the anti-virulence strategy offers an alternative to antibiotic therapeutic approaches when dealing with resistance.

Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for decades.

Staphylococcus aureus (S. aureus) is an asymptomatic colonizer of 30% of all human beings. It is also the most dangerous of all Staphylococcal bacteria.

Mechanisms of antifolate resistance in bacterial and mammalian cells.

The search for new ammunition to combat antibiotic resistance has uncovered diverse inhibitors of the bacterial type IV secretion system.

Inhibition of pyroptosis through targeting the activation or pore-formation of GSDMD.

To push back the growing tide of antibacterial resistance the discovery and development of new antibiotics is a must.

Biofilms are linked to resistance development in the ESKAPE pathogens. This perspective summarizes several strategies for affecting iron homeostasis that have been implicated in biofilm inhibition.

FosM from Mycobacterium abscessus is a Mn²⁺-dependent FosX-type hydrase.

The rapid growth of antibiotic resistance in Staphylococcus aureus coupled with their biofilm forming ability has made the infections difficult to treat with conventional antibiotics.

We report a new scalable and robust synthetic route to the nybomycin natural products and the activity of novel analogues of this family.

Iridium based antimicrobial agents have shown efficacy against S. aureus, including MRSA, and appear to be safe in mice.

N-Aryl urea derivatives were synthesized and some showed activity against mycobacterial hydrolases while others showed antimicrobial activity against mycobacterial species.

Eleven new zafirlukast derivatives selective and bactericidal against Porphyromonas gingivalis.

Fluorescent probes derived from the fluoroquinolone antibiotic ciprofloxacin were synthesised using a Cu(I)-catalysed azide–alkyne cycloaddition (CuAAC) to link a ciprofloxacin azide derivative with alkyne-substituted green and blue fluorophores.

Compounds 1 and 2 disrupt M. tuberculosis membrane potential and demonstrate bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer.

We describe the synthesis and evaluation of 4′-subsituted netilmicin derivatives by selective functionalization at the 4′-position of the endocyclic enolether function.

Biofilm-related UTIs are problematic infectious diseases worldwide; here we have developed a novel ciprofloxacin–dinitroxide conjugate with potent UPEC biofilm-eradication activity.

N-Arylated NH125 analogue 1 rapidly eradicates a diverse panel of drug-resistant bacteria and fungi (≥99.9% kill in 1 to 10 minutes).

We describe a facile synthesis of saccharocin from apramycin by regioselective tetra-azidation and stereospecific oxidative deamination of the amino group.

To address the rising threat of multidrug-resistant (MDR) bacteria, new therapeutic strategies must be developed.

Biofilm formation by mycobacteria can lead to enhanced antibiotic tolerance.

This study details the design, synthesis and bioassay of ‘click’ peptidomimetic compounds which inhibit the adherence of P. gingivalis to S. gordonii, a primary step toward pathogenic colonization of the subgingival pocket.

MIC of oxacillin against S. aureus (MRSA252 strain) reduced from 256 μg mL⁻¹ to 2 μg mL⁻¹.