Transition Metal Piano Stool Complexes with ActivityAgainst S. Aureus and MRSA: It is time to truly think outside of the box.
A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to beeffective and safe anti-microbials with activity againstS. Aureus, including various isolates of me-thicillin resistant strains (MRSA). Comparison to other piano stool complexes with activity againstmycobacteria are made along with a discussion of structure-activity relationships. The struc-tures of one the most active complexes with the ligand cis-1,2-diaminocyclohexane and one ofthe least active complexes with the ligand trans-1,2-diaminocyclohexane are compared and dis-cussed with respect to their drastically different activities. In vitro toxicity for all of the complexes are described. In addition, a mouse study with one of the complexes, [(pentamethylcyclopentadienyl)(cis-1,2-diaminocyclohexane)(chloro)iridium]chloride showed no ill effects on the mice at very high doses.
- This article is part of the themed collection: Antimicrobial Resistance