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Transition Metal Piano Stool Complexes with ActivityAgainst S. Aureus and MRSA: It is time to truly think outside of the box.

Abstract

A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to beeffective and safe anti-microbials with activity againstS. Aureus, including various isolates of me-thicillin resistant strains (MRSA). Comparison to other piano stool complexes with activity againstmycobacteria are made along with a discussion of structure-activity relationships. The struc-tures of one the most active complexes with the ligand cis-1,2-diaminocyclohexane and one ofthe least active complexes with the ligand trans-1,2-diaminocyclohexane are compared and dis-cussed with respect to their drastically different activities. In vitro toxicity for all of the complexes are described. In addition, a mouse study with one of the complexes, [(pentamethylcyclopentadienyl)(cis-1,2-diaminocyclohexane)(chloro)iridium]chloride showed no ill effects on the mice at very high doses.

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Publication details

The article was received on 07 Mar 2019, accepted on 09 May 2019 and first published on 14 May 2019


Article type: Research Article
DOI: 10.1039/C9MD00140A
Med. Chem. Commun., 2019, Accepted Manuscript

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    Transition Metal Piano Stool Complexes with ActivityAgainst S. Aureus and MRSA: It is time to truly think outside of the box.

    C. DuChane, G. Karpin, J. Falkinham, M. Ehrich and J. S. Merola, Med. Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9MD00140A

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