Themed collection 2021 RSC Chemical Biology HOT Article Collection

23 items
Open Access Review Article

Nanobodies as in vivo, non-invasive, imaging agents

In vivo imaging has become in recent years an incredible tool to study biological events and has found critical applications in diagnostic medicine.

Graphical abstract: Nanobodies as in vivo, non-invasive, imaging agents
Open Access Review Article

Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins

This review details a brief history of the synthesis and characterization of metabolic chemical reporters used to study glycosylation before describing recent applications and finishing with considerations and limitations of reporter molecules.

Graphical abstract: Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins
Open Access Review Article

Fragment-based covalent ligand discovery

Covalent fragment-based ligand discovery greatly facilitates the discovery of useful fragments for drug discovery and helps unveil chemical-tractable biological targets in native biological systems.

Graphical abstract: Fragment-based covalent ligand discovery
Open Access Review Article

Biological functions of supramolecular assemblies of small molecules in the cellular environment

Supramolecular assemblies of small molecules, exhibiting emergent properties, are becoming a new and dynamic molecular platform for biological functions and for developing novel therapeutic approaches.

Graphical abstract: Biological functions of supramolecular assemblies of small molecules in the cellular environment
Open Access Review Article

Structural motifs and intramolecular interactions in non-canonical G-quadruplexes

G-rich nucleic acid sequences encompassing G-tracts of varying lengths can fold into different non-canonical G-quadruplexes with distinct structural features.

Graphical abstract: Structural motifs and intramolecular interactions in non-canonical G-quadruplexes
Open Access Review Article

Development and biological applications of sulfur–triazole exchange (SuTEx) chemistry

This review discusses the development of sulfonyl–triazoles and highlights the merits and opportunities for deploying this sulfur electrophile for biological discovery.

Graphical abstract: Development and biological applications of sulfur–triazole exchange (SuTEx) chemistry
Open Access Review Article

The chemical biology of coronavirus host–cell interactions

Chemical biology strategies can play important roles in studying the complexity of SARS-CoV-2–host interactions at molecular level detail.

Graphical abstract: The chemical biology of coronavirus host–cell interactions
Open Access Review Article

Transfer hydrogenation catalysis in cells

Recent developments in transfer hydrogenation catalysis and photocatalysis in cancer cells by synthetic metal complexes are reviewed. They offer exciting new ways to modulate biochemical pathways for drug development and biotechnology.

Graphical abstract: Transfer hydrogenation catalysis in cells
Open Access Review Article

DNA folds threaten genetic stability and can be leveraged for chemotherapy

Alternative DNA structures (including G-quadruplexes and DNA junctions) represent promising targets for combinatorial chemotherapeutic treatments aiming at fostering genomic instability and impeding DNA repair.

Graphical abstract: DNA folds threaten genetic stability and can be leveraged for chemotherapy
Open Access Review Article

Matters of class: coming of age of class III and IV lanthipeptides

In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.

Graphical abstract: Matters of class: coming of age of class III and IV lanthipeptides
Open Access Review Article

Tools for functional dissection of site-specific O-GlcNAcylation

An overview of the latest tools and technologies to investigate the roles of site-specific O-GlcNAcylation in vitro and in vivo.

Graphical abstract: Tools for functional dissection of site-specific O-GlcNAcylation
Open Access Paper

Deciphering the substrate recognition mechanisms of the heparan sulfate 3-O-sulfotransferase-3

Co-crystallization and biochemical analyses with structurally defined oligosaccharides show the low reactivity of HS 3-OST-3 toward 6-O-sulfated substrates is due to inhibition of enzyme activity by 6-O-sulfated oligosaccharides.

Graphical abstract: Deciphering the substrate recognition mechanisms of the heparan sulfate 3-O-sulfotransferase-3
Open Access Paper

Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway

Heterologous expression of an aromatic polyketide biosynthetic gene cluster recovered from a New Zealand soil metagenome library resulted in the discovery of new bioactive aureolic acids.

Graphical abstract: Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway
Open Access Paper

Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions

Glycopolymers based on hyaluronan (HA) were synthesised as homopolymers and alternating copolymers and used as probes to study the interactions with known HA-binding proteins and peptides.

Graphical abstract: Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions
Open Access Paper

Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate

A revision is proposed to the biosynthetic pathway to the well-known red pigment prodigiosin via a new thioester intermediate.

Graphical abstract: Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate
Open Access Paper

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

Using protein semi-synthesis, segmentally isotope-labelled variants of nucleosome-binding protein HMGN1 were generated with site-specific posttranslational modifications to explore their structural and functional effects.

Graphical abstract: Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Open Access Paper

In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides

Cyclic peptides containing unnatural amino acids can modulate Lys-48 ubiquitin chains in cells and animals.

Graphical abstract: In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides
Open Access Paper

In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery

Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared.

Graphical abstract: In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
Open Access Paper

A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions

We show for the first time that PD-1 is palmitoylated, identify DHHC9 as the predominant enzyme for its palmitoylation, and reveal the molecular mechanisms underlying its effects on PD-1 stability and functions. Importantly, we also designed PD1-PALM, a competitive inhibitor of PD-1 palmitoylation, and this first-in-class molecule may inspire the development of new checkpoint inhibitors.

Graphical abstract: A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions
From the themed collection: The Chemical Biology of Peptides
Open Access Paper

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

We identified potent, functionalisable BMX inhibitors and revealed their covalent mode of binding to BMX by X-ray crystallography.

Graphical abstract: Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
Open Access Paper

Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding

Altering local dielectric properties induced by solvent shielding, enhances polar interactions and leads to enthalpically driven recognition of polar substrates.

Graphical abstract: Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding
Open Access Paper

Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents

Naphthalimide-appended oligopyridylamide peptidomimetic modulate islet amyloid polypeptide amyloidogenesis and disaggregate preformed oligomers and fibrils into non-toxic conformations at substoichiometric concentration.

Graphical abstract: Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents
Open Access Paper

A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families

In-depth study of intriguing bacterial interrupted adenylation domains from seven distinct families and six different types.

Graphical abstract: A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
23 items

About this collection

Welcome to our inaugural HOT article collection.

This collection celebrates the very best work published in RSC Chemical Biology.

We hope you enjoy reading these articles and congratulations to all the authors whose articles are featured.

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