Themed collection Biomaterials Science Emerging Investigator Series

The nanoparticle biomolecular corona is affected by patients’ pre-existing conditions and it should be considered when developing novel immunotherapeutics.

Different techniques developed for the encapsulation of biological drugs within polymeric nanoparticles.

This review summarizes the latest advances in TfR1-targeted nanomedicine for brain tumor therapy.

This is the first comprehensive review of glutathione peroxidase-like nanozymes which discusses their mechanism, classification, and bioapplication to further develop this field.

This review highlights the importance of cell metabolism as a missing link connecting the cellular behavior and physicochemical properties of biomaterials and serves as a guiding principle for designing scaffolds for bone tissue engineering.

Review on the biodistribution of mRNA-nanocarrier in primary organs highlighting key parameters for optimal protein expression.

Modified nanoparticles for targeting atherosclerotic overexpressed receptors.

This review summarizes recent progress in the development of biomimetic, membrane-wrapped nanoparticles for targeted delivery of nucleic acids (including siRNA, pDNA, and CpG ODNs) to manage cancer.

This review provides a comprehensive understanding about how different classes of biomaterials, starting from macroscale to nanoscale, interact with bacteria and viruses to exert their antimicrobial properties through diverse mechanisms of action.

Precise control of antimicrobial delivery can prevent the adverse effects of antibiotics.

Suppressive T cells induce anti-inflammatory responses in rheumatoid arthritis (RA) which then reverse inflammation of the joints.

A self-healing antibacterial hydrogel was fabricated for accelerating infected wound healing. This hydrogel possesses biocompatible, self-healing, antibacterial and antibiotic-free properties, and thus is promising as a wound dressing.

An injectable short-fiber reinforced gelatin methacrylate/oxidized dextran (GM/ODex) hydrogel with a double-crosslinking network was developed for irregular wound treatment.

Dry, macroporous scaffolds efficiently transduce T cells, but the mechanism for this transduction has not been studied previously. We report that liquid volume and resultant differences in liquid absorption rates governs cell transduction efficiency.

In this paper we a report a pH-sensitive polycarbonate conjugated with the anticancer drug camptothecin that shows enhanced drug delivery towards cancer cells.

Fabrication process of CFOT and schematic illustration mechanism of CFOT for PTT/CDT synergistic therapy with GSH depletion and tumor targeting.

ROS-responsive polydopamine nanoparticles sustain release of heme–albumin, increasing HO-1 expression in retinal cells, demonstrating a potential therapeutic approach for treatment of inflammatory conditions such as age-related macular degeneration.

Dense coatings with polyethylene glycol (PEG) allow nanoparticles to diffuse within the LN extracellular spaces revealing pore sizes ranging from 500 nm–1.5 μm, contrary to previous literature that predicted pores to be 10–20 μm.

Polymer-nanoparticle hydrogels are assembled by guest–host interactions that also enable drug encapsulation. Surface erosion of celastrol-loaded nanoparticles from injectable hydrogels enables macrophage-targeted delivery to modulate cell phenotype.

BAPCs are PEG free nanoparticles with potential to deliver therapeutic mRNA in vivo. Association of mRNA with BAPCs surface enhanced localization in lung by avoiding liver and spleen. Therefore, potentiating their application in lung therapy.

A triazine based lipid was evaluated in mice for toxicity and transfection efficiency using optimized formulation parameters that result in improved transgene expression as compared to formulations containing commercially available cationic lipids.

Identify and validate inflammatory serum factors as drivers of sex-specific valvular interstitial cell phenotypes on hydrogels.

Self-assembling multidomain peptide hydrogels direct a nearly exclusive humoral adaptive immune response compared to alum, the most widely used adjuvant in vaccines.

Alternative activation (M2 phenotype) of macrophages and reduced phagocytosis is regulated synergistically by increased substrate stiffness and presence of profibrotic soluble cues.

We have demonstrated the ability of mRNA-carrying lipid nanoparticles to activate NLRP3 inflammasomes is highly dependent on lipid composition, affecting the endo/lysosomal rupture or calcium influx/mitochondrial ROS production by the nanoparticle.

The bioactive plant flavonoid rhoifolin was encapsulated in polymeric nanoparticles and evaluated as a potential anti-inflammatory nanomedicine.

Applicability of hydrogels as drug delivery systems is on the rise due to their highly tunable degree of polymeric crosslinking to attain varying rates of payload release.

Not all ionizable lipids are the same – choosing the right one is critical to the success of lipid nanoparticles for different applications.

Bacteria-responsive, hyaluronic acid and chitosan coated antibiotic loaded gelatin nanoparticles effectively penetrate and eradicate bacterial biofilms.

The newly developed oral delivery vehicle composed of Taurocholic Acid and β-Glucan (TAG) has potential delivery biological molecules to liver while administered via orally.

Antioxidant Response Activating nanoParticles (ARAPas), but not un-targeted drug, induce protective genes in atherosclerotic plaque.