Themed collection Biomaterials Science Emerging Investigator Series

27 items
Minireview

Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer

The nanoparticle biomolecular corona is affected by patients’ pre-existing conditions and it should be considered when developing novel immunotherapeutics.

Graphical abstract: Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer
Accepted Manuscript - Review Article

Glutathione peroxidase-like nanozymes: Mechanism, classification, and bioapplication

Accepted Manuscript - Review Article

Cellular metabolism: a link connecting with physiochemical properties of biomaterials for bone tissue engineering

Accepted Manuscript - Review Article

Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: Points to consider between methods

Review Article

Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression

Review on the biodistribution of mRNA-nanocarrier in primary organs highlighting key parameters for optimal protein expression.

Graphical abstract: Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression
Review Article

Surface-modified nanotherapeutics targeting atherosclerosis

Modified nanoparticles for targeting atherosclerotic overexpressed receptors.

Graphical abstract: Surface-modified nanotherapeutics targeting atherosclerosis
Review Article

Membrane-wrapped nanoparticles for nucleic acid delivery

This review summarizes recent progress in the development of biomimetic, membrane-wrapped nanoparticles for targeted delivery of nucleic acids (including siRNA, pDNA, and CpG ODNs) to manage cancer.

Graphical abstract: Membrane-wrapped nanoparticles for nucleic acid delivery
Review Article

Antimicrobial mechanisms of biomaterials: from macro to nano

This review provides a comprehensive understanding about how different classes of biomaterials, starting from macroscale to nanoscale, interact with bacteria and viruses to exert their antimicrobial properties through diverse mechanisms of action.

Graphical abstract: Antimicrobial mechanisms of biomaterials: from macro to nano
Communication

Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses

Suppressive T cells induce anti-inflammatory responses in rheumatoid arthritis (RA) which then reverse inflammation of the joints.

Graphical abstract: Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses
Open Access Paper

Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform

In this paper we a report a pH-sensitive polycarbonate conjugated with the anticancer drug camptothecin that shows enhanced drug delivery towards cancer cells.

Graphical abstract: Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform
Paper

All-in-one CoFe2O4@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy

Fabrication process of CFOT and schematic illustration mechanism of CFOT for PTT/CDT synergistic therapy with GSH depletion and tumor targeting.

Graphical abstract: All-in-one CoFe2O4@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy
Accepted Manuscript - Paper

Absorption Rate Governs Cell Transduction in Dry Macroporous Scaffolds

Paper

Sustained release of heme–albumin as a potential novel therapeutic approach for age-related macular degeneration

ROS-responsive polydopamine nanoparticles sustain release of heme–albumin, increasing HO-1 expression in retinal cells, demonstrating a potential therapeutic approach for treatment of inflammatory conditions such as age-related macular degeneration.

Graphical abstract: Sustained release of heme–albumin as a potential novel therapeutic approach for age-related macular degeneration
Paper

Multiple particle tracking (MPT) using PEGylated nanoparticles reveals heterogeneity within murine lymph nodes and between lymph nodes at different locations

Dense coatings with polyethylene glycol (PEG) allow nanoparticles to diffuse within the LN extracellular spaces revealing pore sizes ranging from 500 nm–1.5 μm, contrary to previous literature that predicted pores to be 10–20 μm.

Graphical abstract: Multiple particle tracking (MPT) using PEGylated nanoparticles reveals heterogeneity within murine lymph nodes and between lymph nodes at different locations
Open Access Paper

Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype

Polymer-nanoparticle hydrogels are assembled by guest–host interactions that also enable drug encapsulation. Surface erosion of celastrol-loaded nanoparticles from injectable hydrogels enables macrophage-targeted delivery to modulate cell phenotype.

Graphical abstract: Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype
Paper

Evaluation of transfection efficacy, biodistribution, and toxicity of branched amphiphilic peptide capsules (BAPCs) associated with mRNA

BAPCs are PEG free nanoparticles with potential to deliver therapeutic mRNA in vivo. Association of mRNA with BAPCs surface enhanced localization in lung by avoiding liver and spleen. Therefore, potentiating their application in lung therapy.

Graphical abstract: Evaluation of transfection efficacy, biodistribution, and toxicity of branched amphiphilic peptide capsules (BAPCs) associated with mRNA
Paper

In vivo assessment of triazine lipid nanoparticles as transfection agents for plasmid DNA

A triazine based lipid was evaluated in mice for toxicity and transfection efficiency using optimized formulation parameters that result in improved transgene expression as compared to formulations containing commercially available cationic lipids.

Graphical abstract: In vivo assessment of triazine lipid nanoparticles as transfection agents for plasmid DNA
Paper

Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation

Identify and validate inflammatory serum factors as drivers of sex-specific valvular interstitial cell phenotypes on hydrogels.

Graphical abstract: Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation
Paper

Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Self-assembling multidomain peptide hydrogels direct a nearly exclusive humoral adaptive immune response compared to alum, the most widely used adjuvant in vaccines.

Graphical abstract: Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity
Paper

Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function

Alternative activation (M2 phenotype) of macrophages and reduced phagocytosis is regulated synergistically by increased substrate stiffness and presence of profibrotic soluble cues.

Graphical abstract: Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function
Paper

mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency

We have demonstrated the ability of mRNA-carrying lipid nanoparticles to activate NLRP3 inflammasomes is highly dependent on lipid composition, affecting the endo/lysosomal rupture or calcium influx/mitochondrial ROS production by the nanoparticle.

Graphical abstract: mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency
Paper

Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation in vitro and in vivo

The bioactive plant flavonoid rhoifolin was encapsulated in polymeric nanoparticles and evaluated as a potential anti-inflammatory nanomedicine.

Graphical abstract: Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation in vitro and in vivo
Paper

Development of gelatin methacrylate (GelMa) hydrogels for versatile intracavitary applications

Applicability of hydrogels as drug delivery systems is on the rise due to their highly tunable degree of polymeric crosslinking to attain varying rates of payload release.

Graphical abstract: Development of gelatin methacrylate (GelMa) hydrogels for versatile intracavitary applications
Paper

In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression

Not all ionizable lipids are the same – choosing the right one is critical to the success of lipid nanoparticles for different applications.

Graphical abstract: In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression
Paper

Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication

Bacteria-responsive, hyaluronic acid and chitosan coated antibiotic loaded gelatin nanoparticles effectively penetrate and eradicate bacterial biofilms.

Graphical abstract: Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication
Paper

Bile acid linked β-glucan nanoparticles for liver specific oral delivery of biologics

The newly developed oral delivery vehicle composed of Taurocholic Acid and β-Glucan (TAG) has potential delivery biological molecules to liver while administered via orally.

Graphical abstract: Bile acid linked β-glucan nanoparticles for liver specific oral delivery of biologics
Paper

Antioxidant Response Activating nanoParticles (ARAPas) localize to atherosclerotic plaque and locally activate the Nrf2 pathway

Antioxidant Response Activating nanoParticles (ARAPas), but not un-targeted drug, induce protective genes in atherosclerotic plaque.

Graphical abstract: Antioxidant Response Activating nanoParticles (ARAPas) localize to atherosclerotic plaque and locally activate the Nrf2 pathway
27 items

About this collection

Biomaterials Science is proud to present this series, showcasing work being conducted by Emerging Investigators. This collection gathers the very best work from biomaterials scientists in the early stages of their independent careers in recognition of their potential to influence future directions in the field.
This collection will be updated when new Emerging Investigator Series papers are published – so keep checking this page and watch the collection grow.
More details about the Emerging Investigator Series can be found on the Biomaterials Science blog, including details on how to apply for consideration and more information about the corresponding authors featured in this collection.

Spotlight

Advertisements