Themed collection Biomaterials Science Emerging Investigator Series
Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer
The nanoparticle biomolecular corona is affected by patients’ pre-existing conditions and it should be considered when developing novel immunotherapeutics.
Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods
Different techniques developed for the encapsulation of biological drugs within polymeric nanoparticles.
Transferrin receptor 1 targeted nanomedicine for brain tumor therapy
This review summarizes the latest advances in TfR1-targeted nanomedicine for brain tumor therapy.
Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication
This is the first comprehensive review of glutathione peroxidase-like nanozymes which discusses their mechanism, classification, and bioapplication to further develop this field.
Cellular metabolism: a link connecting cellular behaviour with the physiochemical properties of biomaterials for bone tissue engineering
This review highlights the importance of cell metabolism as a missing link connecting the cellular behavior and physicochemical properties of biomaterials and serves as a guiding principle for designing scaffolds for bone tissue engineering.
Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression
Review on the biodistribution of mRNA-nanocarrier in primary organs highlighting key parameters for optimal protein expression.
Surface-modified nanotherapeutics targeting atherosclerosis
Modified nanoparticles for targeting atherosclerotic overexpressed receptors.
Membrane-wrapped nanoparticles for nucleic acid delivery
This review summarizes recent progress in the development of biomimetic, membrane-wrapped nanoparticles for targeted delivery of nucleic acids (including siRNA, pDNA, and CpG ODNs) to manage cancer.
Antimicrobial mechanisms of biomaterials: from macro to nano
This review provides a comprehensive understanding about how different classes of biomaterials, starting from macroscale to nanoscale, interact with bacteria and viruses to exert their antimicrobial properties through diverse mechanisms of action.
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels
Precise control of antimicrobial delivery can prevent the adverse effects of antibiotics.
Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses
Suppressive T cells induce anti-inflammatory responses in rheumatoid arthritis (RA) which then reverse inflammation of the joints.
A chitosan-based self-healing hydrogel for accelerating infected wound healing
A self-healing antibacterial hydrogel was fabricated for accelerating infected wound healing. This hydrogel possesses biocompatible, self-healing, antibacterial and antibiotic-free properties, and thus is promising as a wound dressing.
In situ forming double-crosslinked hydrogels with highly dispersed short fibers for the treatment of irregular wounds
An injectable short-fiber reinforced gelatin methacrylate/oxidized dextran (GM/ODex) hydrogel with a double-crosslinking network was developed for irregular wound treatment.
Absorption rate governs cell transduction in dry macroporous scaffolds
Dry, macroporous scaffolds efficiently transduce T cells, but the mechanism for this transduction has not been studied previously. We report that liquid volume and resultant differences in liquid absorption rates governs cell transduction efficiency.
Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform
In this paper we a report a pH-sensitive polycarbonate conjugated with the anticancer drug camptothecin that shows enhanced drug delivery towards cancer cells.
All-in-one CoFe2O4@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy
Fabrication process of CFOT and schematic illustration mechanism of CFOT for PTT/CDT synergistic therapy with GSH depletion and tumor targeting.
Sustained release of heme–albumin as a potential novel therapeutic approach for age-related macular degeneration
ROS-responsive polydopamine nanoparticles sustain release of heme–albumin, increasing HO-1 expression in retinal cells, demonstrating a potential therapeutic approach for treatment of inflammatory conditions such as age-related macular degeneration.
Multiple particle tracking (MPT) using PEGylated nanoparticles reveals heterogeneity within murine lymph nodes and between lymph nodes at different locations
Dense coatings with polyethylene glycol (PEG) allow nanoparticles to diffuse within the LN extracellular spaces revealing pore sizes ranging from 500 nm–1.5 μm, contrary to previous literature that predicted pores to be 10–20 μm.
Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype
Polymer-nanoparticle hydrogels are assembled by guest–host interactions that also enable drug encapsulation. Surface erosion of celastrol-loaded nanoparticles from injectable hydrogels enables macrophage-targeted delivery to modulate cell phenotype.
Evaluation of transfection efficacy, biodistribution, and toxicity of branched amphiphilic peptide capsules (BAPCs) associated with mRNA
BAPCs are PEG free nanoparticles with potential to deliver therapeutic mRNA in vivo. Association of mRNA with BAPCs surface enhanced localization in lung by avoiding liver and spleen. Therefore, potentiating their application in lung therapy.
In vivo assessment of triazine lipid nanoparticles as transfection agents for plasmid DNA
A triazine based lipid was evaluated in mice for toxicity and transfection efficiency using optimized formulation parameters that result in improved transgene expression as compared to formulations containing commercially available cationic lipids.
Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation
Identify and validate inflammatory serum factors as drivers of sex-specific valvular interstitial cell phenotypes on hydrogels.
Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity
Self-assembling multidomain peptide hydrogels direct a nearly exclusive humoral adaptive immune response compared to alum, the most widely used adjuvant in vaccines.
Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function
Alternative activation (M2 phenotype) of macrophages and reduced phagocytosis is regulated synergistically by increased substrate stiffness and presence of profibrotic soluble cues.
mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency
We have demonstrated the ability of mRNA-carrying lipid nanoparticles to activate NLRP3 inflammasomes is highly dependent on lipid composition, affecting the endo/lysosomal rupture or calcium influx/mitochondrial ROS production by the nanoparticle.
Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation in vitro and in vivo
The bioactive plant flavonoid rhoifolin was encapsulated in polymeric nanoparticles and evaluated as a potential anti-inflammatory nanomedicine.
Development of gelatin methacrylate (GelMa) hydrogels for versatile intracavitary applications
Applicability of hydrogels as drug delivery systems is on the rise due to their highly tunable degree of polymeric crosslinking to attain varying rates of payload release.
In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression
Not all ionizable lipids are the same – choosing the right one is critical to the success of lipid nanoparticles for different applications.
Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication
Bacteria-responsive, hyaluronic acid and chitosan coated antibiotic loaded gelatin nanoparticles effectively penetrate and eradicate bacterial biofilms.
Bile acid linked β-glucan nanoparticles for liver specific oral delivery of biologics
The newly developed oral delivery vehicle composed of Taurocholic Acid and β-Glucan (TAG) has potential delivery biological molecules to liver while administered via orally.
Antioxidant Response Activating nanoParticles (ARAPas) localize to atherosclerotic plaque and locally activate the Nrf2 pathway
Antioxidant Response Activating nanoParticles (ARAPas), but not un-targeted drug, induce protective genes in atherosclerotic plaque.