Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels

Meera Patel; Alexander L. Corbett; Aarushi Vardhan; Keuna Jeon; Nesha May O. Andoy; Ruby May A. Sullan

doi:10.1039/D2BM01471H

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Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels†

Meera Patel,‡^ab Alexander L. Corbett,

§‡^ab Aarushi Vardhan,^a Keuna Jeon,

^ab Nesha May O. Andoy

^a and Ruby May A. Sullan

*^ab

Author affiliations

* Corresponding authors

^a Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1065 Military Trail, Toronto, Ontario, Canada
E-mail: ruby.sullan@utoronto.ca

^b Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, Canada

Abstract

Precise control of antimicrobial delivery can prevent the adverse effects of antibiotics. By exploiting the photothermal activity of polydopamine nanoparticles along with the distinct transition temperatures of liposomes, a near-infrared (NIR) laser can be used to control the sequential delivery of an antibiotic and its adjuvant from a nanocomposite hydrogel—preventing bacterial growth.

This article is part of the themed collection: Biomaterials Science Emerging Investigator Series

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Article information

DOI: https://doi.org/10.1039/D2BM01471H
Article type: Communication
Submitted: 10 Sep 2022
Accepted: 02 Mar 2023
First published: 03 Mar 2023

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Biomater. Sci., 2023,11, 2330-2335

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Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels

M. Patel, A. L. Corbett, A. Vardhan, K. Jeon, N. M. O. Andoy and R. M. A. Sullan, Biomater. Sci., 2023, 11, 2330 DOI: 10.1039/D2BM01471H

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Biomaterials Science

Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels†

Abstract

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Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels

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