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Themed collection Biomaterials Science Lectureship Winners

13 items
Minireview

Engineering DNA scaffolds for delivery of anticancer therapeutics

DNA scaffolds with programmability in size, shape and surface chemistry have been engineered for the delivery of various anticancer therapeutics.

Graphical abstract: Engineering DNA scaffolds for delivery of anticancer therapeutics
From the themed collection: Biomaterials Science Lectureship Winners
Open Access Minireview

Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

Hydrogels offer controllable and well-defined in vitro platforms to study the role of the fibroblast in wound healing and fibrosis.

Graphical abstract: Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease
From the themed collection: Emerging Investigators
Review Article

Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.

Graphical abstract: Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics
From the themed collection: Biomaterials Science Lectureship Winners
Communication

Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture

Synthetic multifunctional assembling peptides were designed to mimic the structure of collagen and allow independent control of hydrogel mechanical and biochemical properties through covalent crosslinking, enabling long-term in vitro 3D cell culture.

Graphical abstract: Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture
Communication

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

Enzymatically-responsive bivalirudin polymers loaded in thermoresponsive hydrogels mediate localized therapeutic peptide delivery in spinal cord injuries. These materials respond to upregulated remodelling enzymes to release therapeutic peptide into injured tissue.

Graphical abstract: MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells

In this work, we establish an approach for the three-dimensional (3D) culture and differentiation of induced pluripotent stem cells (iPSCs) within well-defined synthetic matrices using light-based chemistries of relevance for the study of both disease and regeneration.

Graphical abstract: Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Iodine-131-labeled, transferrin-capped polypyrrole nanoparticles for tumor-targeted synergistic photothermal-radioisotope therapy

Tumor-targeting nanoparticles based on transferrin-capped polypyrrole are fabricated by a one-step approach for combination cancer therapy with a remarkable synergistic therapeutic effect.

Graphical abstract: Iodine-131-labeled, transferrin-capped polypyrrole nanoparticles for tumor-targeted synergistic photothermal-radioisotope therapy
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release

Poly(ethylene glycol) hydrogel crosslinking mechanism has a differential effect on controlling protein release.

Graphical abstract: Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Reducible, dibromomaleimide-linked polymers for gene delivery

Reducible, dibromomaleimide-linked polycations exhibit reduced cytotoxicity compared to their non-degradable analogs and can be site-specifically functionalized.

Graphical abstract: Reducible, dibromomaleimide-linked polymers for gene delivery
From the themed collection: Biomaterials Science Lectureship Winners
Open Access Paper

Design of thiol–ene photoclick hydrogels using facile techniques for cell culture applications

Thiol–ene photoclick hydrogels with tunable biomechanical and biochemical properties for biological applications, including controlled cell culture, regenerative medicine, and drug delivery.

Graphical abstract: Design of thiol–ene photoclick hydrogels using facile techniques for cell culture applications
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides

Inserting an ester bond into self-assembling peptides generated controllably degradable nanofibers and hydrogels for 3D cell culture.

Graphical abstract: Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery

Guanidinylated HPMA-co-oligolysine copolymers exhibit higher transfection efficiency to cultured cells than analogous lysine-based polymers for nucleic acid delivery.

Graphical abstract: Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery
From the themed collection: Biomaterials Science Lectureship Winners
Paper

Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons

Presented is an engineered PEG hydrogel capable of supporting the viability and subsequent axon extension of encapsulated mouse embryonic stem cell-derived motor neurons in 3D.

Graphical abstract: Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons
From the themed collection: Biomaterials Science Lectureship Winners
13 items

About this collection

This collection highlights winners of the Biomaterials Science Lectureship. This annual award was established in 2014 to honour an early-stage career scientist who has made a significant contribution to the biomaterials field.

The 2020 Biomaterials Science Lectureship was awarded to Kanyi Pu (Nanyang Technological University).

Dr. Pu is an Associate Professor in the School of Chemical and Biomedical Engineering (SCBE) at Nanyang Technological University. He is a highly cited researcher, associate editor for ACS Applied Polymer Materials and Biomaterials Research, and Young Star Editor of Nano Research.

Dr. Pu has made significant contributions to the development of molecular imaging probes and technologies, particularly for photoacoustic imaging, chemiluminescence imaging and afterglow imaging. He is well known for his work on semiconducting polymer nanomaterials (SPNs) for molecular imaging, phototherapy and photoregulation. He is the inventor of the polymeric nanoreporters for molecular afterglow imaging and the molecular optical renal reporters for early diagnosis of acute kidney injury (AKI).

This collection features articles published in Biomaterials Science from Kanyi Pu as well as the six previous lectureship winners: 

2019 - April Kloxin, University of Delaware, USA

2018 - Zhen Gu, University of North Carolina at Chapel Hill & North Carolina State University, USA

2017 - Zhuang Liu, Foochow University, China

2016 – Fan Yang, Stanford University, USA

2015 – Joel Collier, Duke University, USA

2014 – Suzie Pun, University of Washington, USA

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