Engineering DNA scaffolds for delivery of anticancer therapeutics
DNA scaffolds with programmability in size, shape and surface chemistry have been engineered for the delivery of various anticancer therapeutics.
Minireview
Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease
Hydrogels offer controllable and well-defined in vitro platforms to study the role of the fibroblast in wound healing and fibrosis.
Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics
Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.
Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture
Synthetic multifunctional assembling peptides were designed to mimic the structure of collagen and allow independent control of hydrogel mechanical and biochemical properties through covalent crosslinking, enabling long-term in vitro 3D cell culture.
MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition
Enzymatically-responsive bivalirudin polymers loaded in thermoresponsive hydrogels mediate localized therapeutic peptide delivery in spinal cord injuries. These materials respond to upregulated remodelling enzymes to release therapeutic peptide into injured tissue.
Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
In this work, we establish an approach for the three-dimensional (3D) culture and differentiation of induced pluripotent stem cells (iPSCs) within well-defined synthetic matrices using light-based chemistries of relevance for the study of both disease and regeneration.
Iodine-131-labeled, transferrin-capped polypyrrole nanoparticles for tumor-targeted synergistic photothermal-radioisotope therapy
Tumor-targeting nanoparticles based on transferrin-capped polypyrrole are fabricated by a one-step approach for combination cancer therapy with a remarkable synergistic therapeutic effect.
Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release
Poly(ethylene glycol) hydrogel crosslinking mechanism has a differential effect on controlling protein release.
Reducible, dibromomaleimide-linked polymers for gene delivery
Reducible, dibromomaleimide-linked polycations exhibit reduced cytotoxicity compared to their non-degradable analogs and can be site-specifically functionalized.
Paper
Design of thiol–ene photoclick hydrogels using facile techniques for cell culture applications
Thiol–ene photoclick hydrogels with tunable biomechanical and biochemical properties for biological applications, including controlled cell culture, regenerative medicine, and drug delivery.
Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides
Inserting an ester bond into self-assembling peptides generated controllably degradable nanofibers and hydrogels for 3D cell culture.
Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery
Guanidinylated HPMA-co-oligolysine copolymers exhibit higher transfection efficiency to cultured cells than analogous lysine-based polymers for nucleic acid delivery.
Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons
Presented is an engineered PEG hydrogel capable of supporting the viability and subsequent axon extension of encapsulated mouse embryonic stem cell-derived motor neurons in 3D.
About this collection
This collection highlights winners of the Biomaterials Science Lectureship. This annual award was established in 2014 to honour an early-stage career scientist who has made a significant contribution to the biomaterials field.
The 2020 Biomaterials Science Lectureship was awarded to Kanyi Pu (Nanyang Technological University).
Dr. Pu is an Associate Professor in the School of Chemical and Biomedical Engineering (SCBE) at Nanyang Technological University. He is a highly cited researcher, associate editor for ACS Applied Polymer Materials and Biomaterials Research, and Young Star Editor of Nano Research.
Dr. Pu has made significant contributions to the development of molecular imaging probes and technologies, particularly for photoacoustic imaging, chemiluminescence imaging and afterglow imaging. He is well known for his work on semiconducting polymer nanomaterials (SPNs) for molecular imaging, phototherapy and photoregulation. He is the inventor of the polymeric nanoreporters for molecular afterglow imaging and the molecular optical renal reporters for early diagnosis of acute kidney injury (AKI).
This collection features articles published in Biomaterials Science from Kanyi Pu as well as the six previous lectureship winners:
2019 - April Kloxin, University of Delaware, USA
2018 - Zhen Gu, University of North Carolina at Chapel Hill & North Carolina State University, USA
2017 - Zhuang Liu, Foochow University, China
2016 – Fan Yang, Stanford University, USA
2015 – Joel Collier, Duke University, USA
2014 – Suzie Pun, University of Washington, USA