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Themed collection SPEC 2018: International Society of Clinical Spectroscopy

30 items
Editorial

SPEC 2018: International Society of Clinical Spectroscopy

Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Dr. Matthew Baker.

Graphical abstract: SPEC 2018: International Society of Clinical Spectroscopy
Minireview

Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer.

Graphical abstract: Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease
From the themed collection: Recent Review Articles
Critical Review

Biomedical applications of mid-infrared quantum cascade lasers – a review

Quantum cascade lasers with high spectral power density and narrow band emission profiles provide novel access to biomedical applications.

Graphical abstract: Biomedical applications of mid-infrared quantum cascade lasers – a review
From the themed collection: Recent Review Articles
Critical Review

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

This review examines the state-of-the-art of clinical applications of infrared absorption and Raman spectroscopy, outstanding challenges, and progress towards translation.

Graphical abstract: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges
From the themed collection: Recent Review Articles
Open Access Communication

Dual purpose fibre – SERS pH sensing and bacterial analysis

A way to incorporate SERS nanosensors on the end of an optical fibre that also allows for the extraction of bacterial samples.

Graphical abstract: Dual purpose fibre – SERS pH sensing and bacterial analysis
Communication

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.

Graphical abstract: Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
Paper

Three-dimensional depth profiling of prostate tissue by micro ATR-FTIR spectroscopic imaging with variable angles of incidence

Variable angle micro ATR-FTIR, via the insertion of circular apertures, was used to measure tissue samples at various penetration depths.

Graphical abstract: Three-dimensional depth profiling of prostate tissue by micro ATR-FTIR spectroscopic imaging with variable angles of incidence
Open Access Paper

Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480

A novel photosensitiser, DC473, designed with solvatochromatic fluorescence and distinct Raman signal, is detected with tandem fluoRaman in SW480 cells.

Graphical abstract: Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480
Open Access Paper

Characterization of inflammatory breast cancer: a vibrational microspectroscopy and imaging approach at the cellular and tissue level

Inflammatory breast cancer (IBC) has a poor prognosis because of the lack of specific biomarkers and its late diagnosis.

Graphical abstract: Characterization of inflammatory breast cancer: a vibrational microspectroscopy and imaging approach at the cellular and tissue level
Open Access Paper

Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains

Non-negative factorization analysis applied to spontaneous Brillouin microscopy maps of amyloid-beta plaques in a transgenic mouse model enables to resolve spatially distinct components with specific mechanical properties.

Graphical abstract: Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains
Paper

Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy

Pre-processing is an essential step in the analysis of spectral data.

Graphical abstract: Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy
Paper

Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy

This study demonstrates the efficacy and distribution of sorafenib in colon cancer cells by label-free Raman microscopy.

Graphical abstract: Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy
Paper

Different binding sites of serum albumins in the protein corona of gold nanoparticles

Binding sites of albumins on gold nanoparticles were characterized by surface-enhanced Raman scattering.

Graphical abstract: Different binding sites of serum albumins in the protein corona of gold nanoparticles
Paper

Raman spectroscopic features of primary cardiac microvascular endothelial cells (CMECs) isolated from the murine heart

Gaining knowledge on the biochemical profile of primary endothelial cells on a subcellular level can contribute to better understanding of cardiovascular disease.

Graphical abstract: Raman spectroscopic features of primary cardiac microvascular endothelial cells (CMECs) isolated from the murine heart
Paper

ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(II) complexes

ATR-FTIR spectroscopy has been applied to compare the effect of new organoamidoplatinum(II) complexes with cisplatin on cells from a cisplatin-sensitive and a cisplatin-resistant ovarian cancer cell line.

Graphical abstract: ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(ii) complexes
Paper

A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics

Translating Raman spectroscopy for colorectal cancer diagnosis with a focus on high-throughput design, inter-user variability and sample handling considerations.

Graphical abstract: A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics
Paper

Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy

A probe-based Raman spectroscopy system using a single laser module with two excitation wavelengths has been developed for measuring the fingerprint and high wavenumber regions with a single detector.

Graphical abstract: Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy
Paper

New insights of Raman spectroscopy for oral clinical applications

Oral injuries are currently diagnosed by histopathological analysis of biopsy, which is an invasive procedure and does not give immediate results.

Graphical abstract: New insights of Raman spectroscopy for oral clinical applications
Paper

Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags

Spectral information relevant to the quality of stored blood can be obtained in situ through sealed blood transfusion bags using a commercially available instrument.

Graphical abstract: Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags
Paper

Towards a quantum cascade laser-based implant for the continuous monitoring of glucose

An in vitro investigation of a quantum cascade laser-based transflection optofluidic interface for the continuous glucose monitoring in biofluids is presented with respect to its glucose sensitivity and specificity, its glucose exchange time, its resistance against temperature variations and its long-term stability.

Graphical abstract: Towards a quantum cascade laser-based implant for the continuous monitoring of glucose
Paper

Optimizing decision tree structures for spectral histopathology (SHP)

This paper reviews methods to arrive at optimum decision tree or label tree structures to analyze large SHP datasets.

Graphical abstract: Optimizing decision tree structures for spectral histopathology (SHP)
Paper

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei

First near-field infrared spectroscopy and imaging of lymphocyte nucleus at 30 nm spatial resolution reveals spectrochemically distinct regions in nuclear organization.

Graphical abstract: Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei
From the themed collection: Recent HOT articles
Paper

Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing

This study explores the potential of Raman spectroscopy, coupled with multivariate regression techniques and ion exchange chromatography, to quantitatively monitor diagnostically relevant changes in high molecular weight proteins in liquid plasma.

Graphical abstract: Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing
Paper

Raman spectroscopy as a novel tool for fast characterization of the chemical composition of perivascular adipose tissue

One of the new targets of untapped therapeutic potential is perivascular adipose tissue (pVAT). Based on Raman spectroscopy we demonstrated that the lipid unsaturation degree was clearly distinct in various types of adipose tissues, in particular thoracic and abdominal pVATs, and was influenced by the age of animals.

Graphical abstract: Raman spectroscopy as a novel tool for fast characterization of the chemical composition of perivascular adipose tissue
Paper

How to unravel the chemical structure and component localization of individual drug-loaded polymeric nanoparticles by using tapping AFM-IR

We describe here the theoretical basis of the innovative tapping AFM-IR mode that can address novel challenges in imaging and chemical mapping of polymeric nanoparticles.

Graphical abstract: How to unravel the chemical structure and component localization of individual drug-loaded polymeric nanoparticles by using tapping AFM-IR
From the themed collection: Recent HOT articles
Paper

Diagnosis of pancreatic cancer via1H NMR metabolomics of human plasma

The investigation of blood plasma via1H NMR metabolomics revealed a panel of potential biomarkers of pancreatic cancer.

Graphical abstract: Diagnosis of pancreatic cancer via1H NMR metabolomics of human plasma
Paper

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model

PCA score of FTIR spectra in fingerprint region for cultured chondrocytes at day 7, 14 and 21 in HA hydrogel showing that the 3D culture drove chondrocytes (CY) to chondron-like (CN) structure dynamically.

Graphical abstract: Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model
Paper

Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer

Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced resonance Raman spectroscopy (SERRS).

Graphical abstract: Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer
Paper

Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease

Plasma samples deposited on low-E slides were analysed in transmission mode by using a FT-NIR spectrometer in order to detect Alzheimer's disease using computer-based methods.

Graphical abstract: Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease
Paper

Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy

A method to acquire the Raman spectra of sub-surface components using diffusely focused radiation in a microscope sampling configuration is described.

Graphical abstract: Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy
30 items

About this collection

This collection of articles highlights work from the 10th conference in the successful SPEC series, held in Glasgow, UK, 10 June – 15 June 2018. The meeting featured research from scientists and clinicians, both from academia and industry, who are developing spectroscopic instrumentation and techniques to improve world health. Guest Edited by Conference Organising Committee Chair and Analyst Advisory Board Member Matthew Baker (University of Strathclyde, UK), the collection includes a topical review article by Hugh J. Byrne et al. titled “ Clinical applications of infrared and Raman spectroscopy: state of play and future challenges”.

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