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Themed collection SPEC 2018: International Society of Clinical Spectroscopy

13 items
Critical Review

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

This review examines the state-of-the-art of clinical applications of infrared absorption and Raman spectroscopy, outstanding challenges, and progress towards translation.

Graphical abstract: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges
Open Access Communication

Dual purpose fibre – SERS pH sensing and bacterial analysis

A way to incorporate SERS nanosensors on the end of an optical fibre that also allows for the extraction of bacterial samples.

Graphical abstract: Dual purpose fibre – SERS pH sensing and bacterial analysis
Communication

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.

Graphical abstract: Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
Accepted Manuscript - Paper

Optimizing Decision Tree Structures for Spectral Histopathology (SHP)

Paper

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model

PCA score of FTIR spectra in fingerprint region for cultured chondrocytes at day 7, 14 and 21 in HA hydrogel showing that the 3D culture drove chondrocytes (CY) to chondron-like (CN) structure dynamically.

Graphical abstract: Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model
Accepted Manuscript - Paper

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei

Accepted Manuscript - Paper

Raman spectroscopic analysis of High Molecular Weight Proteins in solution– considerations for sample analysis and data pre-processing

Paper

Diagnosis of pancreatic cancer via 1H NMR metabolomics of human plasma

The investigation of blood plasma via 1H NMR metabolomics revealed a panel of potential biomarkers of pancreatic cancer.

Graphical abstract: Diagnosis of pancreatic cancer via 1H NMR metabolomics of human plasma
Accepted Manuscript - Paper

Raman spectroscopy as a novel tool for fast characterization of perivascular adipose tissue chemical composition

Accepted Manuscript - Paper

How to Unravel the Chemical Structure and Component Localization of Individual Drug-Loaded Polymeric Nanoparticles by Using Tapping AFM-IR

Paper

Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer

Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced resonance Raman spectroscopy (SERRS).

Graphical abstract: Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer
Paper

Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease

Plasma samples deposited on low-E slides were analysed in transmission mode by using a FT-NIR spectrometer in order to detect Alzheimer's disease using computer-based methods.

Graphical abstract: Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease
Paper

Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy

A method to acquire the Raman spectra of sub-surface components using diffusely focused radiation in a microscope sampling configuration is described.

Graphical abstract: Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy
13 items

About this collection

This collection of articles highlights work from the 10th conference in the successful SPEC series, held in Glasgow, UK, 10 June – 15 June 2018. The meeting featured research from scientists and clinicians, both from academia and industry, who are developing spectroscopic instrumentation and techniques to improve world health. Guest Edited by Conference Organising Committee Chair and Analyst Advisory Board Member Matthew Baker (University of Strathclyde, UK), the collection includes a topical review article by Hugh J. Byrne et al. titled “ Clinical applications of infrared and Raman spectroscopy: state of play and future challenges”.

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