Themed collection 2018 Chemical Science HOT Article Collection
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A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation
An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease.
Chem. Sci., 2019,10, 1634-1643
https://doi.org/10.1039/C8SC04660C
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In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
In this work, a novel NIR two-photon fluorescence probe DCM-APN is reported for tracking APN in vitro and in vivo.
Chem. Sci., 2019,10, 1619-1625
https://doi.org/10.1039/C8SC04685A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Electrocatalytic reduction of low concentration CO2
Electrocatalytic reduction of low concentration CO2 was selectively and efficiently carried out by using a Re(I) complex with high CO2-capturing ability.
Chem. Sci., 2019,10, 1597-1606
https://doi.org/10.1039/C8SC04124E
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Rare “Janus”-faced
single-molecule magnet exhibiting intramolecular ferromagnetic interactions
The unusual ferromagnetically coupled compound was prepared by the use of Me3SiN3 with the metal ions being exclusively bridged by end-on N3−. Th cationic molecule is a rare example of a 3d-metal cluster exhibiting a “Janus”-faced SMM behavior for the dried and wet forms.
Chem. Sci., 2019,10, 1626-1633
https://doi.org/10.1039/C8SC04384A
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Mapping the polymorphic transformation gateway vibration in crystalline 1,2,4,5-tetrabromobenzene
A single lattice vibration at 15.5 cm−1 serves as a gateway for the polymorphic conversion of thermosalient 1,2,4,5-tetrabromobenzene crystals.
Chem. Sci., 2019,10, 1332-1341
https://doi.org/10.1039/C8SC03897J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Sodium-coupled electron transfer reactivity of metal–organic frameworks containing titanium clusters: the importance of cations in redox chemistry
Storage of electrons in the Ti8O8 nodes of MOF MIL-125 is controlled by the presence of charge-balancing Na+ cations.
Chem. Sci., 2019,10, 1322-1331
https://doi.org/10.1039/C8SC04138E
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Self-assembled M12L24 nanospheres as a reaction vessel to facilitate a dinuclear Cu(I) catalyzed cyclization reaction
The application of large M12L24 nanospheres allows the pre-concentration of catalysts to reach high local concentrations, facilitating reactions that proceed through dinuclear mechanisms.
Chem. Sci., 2019,10, 1316-1321
https://doi.org/10.1039/C8SC03767A
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Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening
A FRET-based method was developed for monitoring metal–amyloid-β complexation and identifying inhibitors against such interaction.
Chem. Sci., 2019,10, 1000-1007
https://doi.org/10.1039/C8SC04943B
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Defying strain in the synthesis of an electroactive bilayer helicene
Visible-light-induced oxidative cyclization of a phenanthrene framework overcomes immense strain to yield a bilayer perylene-diimide helicene.
Chem. Sci., 2019,10, 1029-1034
https://doi.org/10.1039/C8SC04216K
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Fluorogenic atom transfer radical polymerization in aqueous media as a strategy for detection
A new method for detecting polymerization and amplifying initiator signals is established by fluorogenic atom transfer radical polymerization.
Chem. Sci., 2019,10, 1017-1022
https://doi.org/10.1039/C8SC03938K
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Chemical and photochemical DNA “gears” reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels
Stimuli-responsive polyacrylamide hydrogels crosslinked by glucosamine–boronate/G-quadruplexes or azobenzene-functionalized DNA reveal controlled stiffness using chemical or photochemical triggers.
Chem. Sci., 2019,10, 1008-1016
https://doi.org/10.1039/C8SC04292F
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A highly soluble, crystalline covalent organic framework compatible with device implementation
We report a soluble yet crystalline covalent organic framework (COF) by regulation of inter-layer interactions, which endows the COF with remarkable solubility and processability of thin films for optoelectronic devices that exhibit high yet anisotropic conductivities and outperform all the other COF-based semiconductors.
Chem. Sci., 2019,10, 1023-1028
https://doi.org/10.1039/C8SC04255A
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Lytic reactions of drugs with lipid membranes
The involvement of drugs in direct chemical reactions with lipids may be linked to toxic effects in liver cell lines.
Chem. Sci., 2019,10, 674-680
https://doi.org/10.1039/C8SC04831B
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Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols
We report an efficient and economical method for remote δ C(sp3)–H heteroarylation of free aliphatic alcohols using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis.
Chem. Sci., 2019,10, 688-693
https://doi.org/10.1039/C8SC04134B
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Single-molecule photoredox catalysis
Photocatalytic dehalogenation by a common dyestuff under aqueous conditions is driven by energy-additive absorption of two photons on the single-molecule level.
Chem. Sci., 2019,10, 681-687
https://doi.org/10.1039/C8SC03860K
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Single Ru atoms with precise coordination on a monolayer layered double hydroxide for efficient electrooxidation catalysis
Single Ru atoms are uniquely located on the top of trivalence Fe atom of NiFe layered double hydroxide.
Chem. Sci., 2019,10, 378-384
https://doi.org/10.1039/C8SC04480E
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A lithium-ion-active aerolysin nanopore for effectively trapping long single-stranded DNA
By developing lithium-ion-active aerolysin, for the first time we have achieved aerolysin detection of single-stranded DNA longer than 100 nt.
Chem. Sci., 2019,10, 354-358
https://doi.org/10.1039/C8SC03927E
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Nuclear singlet multimers (NUSIMERs) with long-lived singlet states
We are introducing nuclear spin singlet multimers which are molecules that contain several nuclear singlet states that can be populated at the same time.
Chem. Sci., 2019,10, 413-417
https://doi.org/10.1039/C8SC02831A
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Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylates
Polyelectrolyte/microemulsion complexes (PEMECs) are very versatile hybrid systems, combining high loading capacities of microemulsions with larger-scale structuring induced by polyelectrolytes.
Chem. Sci., 2019,10, 385-397
https://doi.org/10.1039/C8SC04013C
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Reversibility and reactivity in an acid catalyzed cyclocondensation to give furanochromanes – a reaction at the ‘oxonium-Prins’ vs. ‘ortho-quinone methide cycloaddition’ mechanistic nexus
Herein we report a combined experimental and computational investigation of the acid catalyzed cyclocondensation reaction between styrenyl homoallylic alcohols and salicylaldehyde to form furanochromanes.
Chem. Sci., 2019,10, 406-412
https://doi.org/10.1039/C8SC04302G
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An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells
We describe an enzyme-regulated liberation strategy to in situ generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.
Chem. Sci., 2019,10, 398-405
https://doi.org/10.1039/C8SC04266G
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Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions
A post-transition state bifurcation (PTSB) involved in a Pummerer-type rearrangement is characterized using density functional theory (DFT) calculations on potential energy stationary points and direct dynamics simulations.
Chem. Sci., 2018,9, 8937-8945
https://doi.org/10.1039/C8SC02653J
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Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
The direct Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes have been accomplished using aniline as the transient ligand and alkyl boron reagents as the coupling partner.
Chem. Sci., 2018,9, 8951-8956
https://doi.org/10.1039/C8SC03606C
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Enhanced annihilation electrochemiluminescence by nanofluidic confinement
The generation of stable enhanced light emission by electrochemiluminescence in microfabricated nanofluidic electrochemical devices is demonstrated for the first time by exploiting nanogap amplification.
Chem. Sci., 2018,9, 8946-8950
https://doi.org/10.1039/C8SC03209B
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Cs3VO(O2)2CO3: an exceptionally thermostable carbonatoperoxovanadate with an extremely large second-harmonic generation response
A highly thermostable carbonatoperoxovanadate, Cs3VO(O2)2CO3, exhibits a remarkably strong SHG response of approximately 23.0 times that of KDP, which is the largest among those of the reported NLO carbonate materials.
Chem. Sci., 2018,9, 8957-8961
https://doi.org/10.1039/C8SC03672A
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A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster
Highly efficient synthesis of biomimetic peptoid sequences enables the rapid design and optimization of chelating ligands for multimetallic clusters.
Chem. Sci., 2018,9, 8806-8813
https://doi.org/10.1039/C8SC04240C
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Carbon-supported Ni nanoparticles for efficient CO2 electroreduction
Carbon-coated Ni nanoparticles supported on N-doped carbon enable efficient electroreduction of CO2 to CO comparable to single Ni sites.
Chem. Sci., 2018,9, 8775-8780
https://doi.org/10.1039/C8SC03732A
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Antimicrobial peptide based magnetic recognition elements and Au@Ag-GO SERS tags with stable internal standards: a three in one biosensor for isolation, discrimination and killing of multiple bacteria in whole blood
A SERS based biosensor has been developed for isolation, detection and killing of multiple bacterial pathogens.
Chem. Sci., 2018,9, 8781-8795
https://doi.org/10.1039/C8SC04637A
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A high performance lithium-ion–sulfur battery with a free-standing carbon matrix supported Li-rich alloy anode
A high-performance lithium-ion–sulfur battery has been built by using a carbon supported Li-rich alloy anode and sulfurized polyacrylonitrile (S@pPAN) cathode.
Chem. Sci., 2018,9, 8829-8835
https://doi.org/10.1039/C8SC02897D
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Silver-mediated oxidative functionalization of alkylsilanes
A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported.
Chem. Sci., 2018,9, 8836-8841
https://doi.org/10.1039/C8SC03730B
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Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces
2D coordination polymers grow spontaneously on reactive surfaces due to surface oxidation. The growth process is observed in real time.
Chem. Sci., 2018,9, 8819-8828
https://doi.org/10.1039/C8SC03067G
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Chiral molecular face-rotating sandwich structures constructed through restricting the phenyl flipping of tetraphenylethylene
Complex arrangements of tetraphenylethylene motifs resulted in a variety of chiralities of face-rotating sandwich structures (FRSs).
Chem. Sci., 2018,9, 8814-8818
https://doi.org/10.1039/C8SC03404D
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Shape-selective crystallisation of fluxional carbon cages
Overall molecular shape, rather than any specific noncovalent interactions, controls the preferential crystallisation of shapeshifting barbaralane isomers from dynamic mixtures.
Chem. Sci., 2018,9, 8631-8636
https://doi.org/10.1039/C8SC04303E
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Computational design of a molecular triple photoswitch for wavelength-selective control
meta-Trisazobenzenes allow for wavelength-selective photo-switching of the individual azobenzene branches.
Chem. Sci., 2018,9, 8665-8672
https://doi.org/10.1039/C8SC03379J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Realization of high-power-efficiency white electroluminescence from a single polymer by energy-level engineering
Single white light-emitting polymers with a record power efficiency of 52.1 lm W−1 are realized by energy-level engineering of poly(arylene phosphine oxide)-based phosphorescent polymers.
Chem. Sci., 2018,9, 8656-8664
https://doi.org/10.1039/C8SC03753A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Atomic structure of boron resolved using machine learning and global sampling
Here, by combining machine learning with the latest stochastic surface walking (SSW) global optimization, we explore for the first time the potential energy surface of β-B.
Chem. Sci., 2018,9, 8644-8655
https://doi.org/10.1039/C8SC03427C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Tailored homo- and hetero- lanthanide porphyrin dimers: a synthetic strategy for integrating multiple spintronic functionalities into a single molecule
We present molecular magnetic systems that contain all elements necessary for spin-valve control in molecular spintronic devices in a single molecule.
Chem. Sci., 2018,9, 8474-8481
https://doi.org/10.1039/C8SC03762K
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A glucose/O2 fuel cell-based self-powered biosensor for probing a drug delivery model with self-diagnosis and self-evaluation
A highly compact and self-sustained in vitro “diagnosis-therapy-evaluation” platform is developed by integrating a glucose/O2 fuel cell-based biosensor with a drug delivery system.
Chem. Sci., 2018,9, 8482-8491
https://doi.org/10.1039/C8SC04019B
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An evolutionary algorithm for the discovery of porous organic cages
An evolutionary algorithm is developed and used to search for shape persistent porous organic cages.
Chem. Sci., 2018,9, 8513-8527
https://doi.org/10.1039/C8SC03560A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions
The fluorescence of fluorescent proteins with noncovalently encapsulated chromophore is enhanced by complex interactions between chromophore, protein and bound water.
Chem. Sci., 2018,9, 8325-8336
https://doi.org/10.1039/C8SC03558J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Reductive cleavage of C
C bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S
Four effective probes with turn-off to turn-on fluorescence switches were successfully applied for sensing H2S.
Chem. Sci., 2018,9, 8369-8374
https://doi.org/10.1039/C8SC03430C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst.
Chem. Sci., 2018,9, 8363-8368
https://doi.org/10.1039/C8SC03081B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study
Ion-mobility mass spectrometry and DFT calculations reveal the surprisingly solvent-dependent formation of large pentameric [N⋯I+⋯N] halogen-bonded capsules.
Chem. Sci., 2018,9, 8343-8351
https://doi.org/10.1039/C8SC03040E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2
We investigated the binding mechanism of PI(4,5)P2 and variants on the inwardly rectifying potassium channel, Kir2.2. Our results not only demonstrated the molecular origin for their binding specificity, but also revealed the major driving forces.
Chem. Sci., 2018,9, 8352-8362
https://doi.org/10.1039/C8SC01284A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR
A fast NMR data acquisition strategy is explored to detect and characterize carbocations on solid zeolites.
Chem. Sci., 2018,9, 8184-8193
https://doi.org/10.1039/C8SC03848A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice
ClO1, a ratiometric fluorescent probe, effectively captured endogenous HClO in the lungs of a lipopolysaccharide (LPS)-induced lung inflammation mouse model after intravenous administration.
Chem. Sci., 2018,9, 8207-8212
https://doi.org/10.1039/C8SC03226B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc
A glycopeptide bearing a bisecting glucosamine, a rare N-glycan branch, and two LewisX trisaccharides was synthesized for the first time.
Chem. Sci., 2018,9, 8194-8206
https://doi.org/10.1039/C8SC02457J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Advanced microRNA-based cancer diagnostics using amplified time-gated FRET
FRET and rolling circle amplification outperform RT-qPCR for microRNA diagnostics in clinical samples.
Chem. Sci., 2018,9, 8046-8055
https://doi.org/10.1039/C8SC03121E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes
A series of rare earth complexes of the form Ln(LR)3 supported by bidentate ortho-aryloxide–NHC ligands are reported (LR = O(o-C6H2–tBu2-2,6-CN(C2H2)NR); R = iPr, tBu, Mes; Ln = Ce, Sm, Eu).
Chem. Sci., 2018,9, 8035-8045
https://doi.org/10.1039/C8SC03312A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source
A convenient, miniaturized reverse electrodialysis battery to provide long-lasting and reliable ionic electricity is developed.
Chem. Sci., 2018,9, 8071-8076
https://doi.org/10.1039/C8SC02954G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Unravelling the origins of ice nucleation on organic crystals
Organic molecules such as steroids or amino acids form crystals that can facilitate the formation of ice – arguably the most important phase transition on earth.
Chem. Sci., 2018,9, 8077-8088
https://doi.org/10.1039/C8SC02753F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Protonated glycine supramolecular systems: the need for quantum dynamics
Quantum mechanical simulations unequivocally explain experimental IR spectra of protonated supramolecular systems.
Chem. Sci., 2018,9, 7894-7901
https://doi.org/10.1039/C8SC03041C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis
The first direct syntheses, structural characterizations, and reactivity studies of multinuclear iron–phenyl species formed upon reaction of Fe(acac)3 and PhMgBr in THF are described.
Chem. Sci., 2018,9, 7931-7939
https://doi.org/10.1039/C8SC02915F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid
The identification of trace components from an individual cell can require derivatization under mild conditions for successful analysis by mass spectrometry (MS).
Chem. Sci., 2018,9, 7779-7786
https://doi.org/10.1039/C8SC03382J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Chimera: enabling hierarchy based multi-objective optimization for self-driving laboratories
Chimera enables multi-target optimization for experimentation or expensive computations, where evaluations are the limiting factor.
Chem. Sci., 2018,9, 7642-7655
https://doi.org/10.1039/C8SC02239A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials
Microscale uniformity and long-range cohesion in multi-functional films assembled through drop-casting is realized by in situ gelation of monodisperse building blocks.
Chem. Sci., 2018,9, 7596-7605
https://doi.org/10.1039/C8SC03302A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
The double-faced Janus lectin, designed by assembling sialic acid and fucose-specific lectin, organize multivalent heteroglyco compounds in mulitlayered material, and glycosylated protocells in prototissues.
Chem. Sci., 2018,9, 7634-7641
https://doi.org/10.1039/C8SC02730G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams
A palladium(II)-catalysed C(sp3)–H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described.
Chem. Sci., 2018,9, 7628-7633
https://doi.org/10.1039/C8SC02855A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(III) protoporphyrin IX and its application as a supramolecular photosensitizer
A 4-aminoquinoline-based molecular tweezer was developed as a synthetic receptor for protoporphyrin IX and iron(III) protoporphyrin IX, and applied as a supramolecular photosensitizer.
Chem. Sci., 2018,9, 7455-7467
https://doi.org/10.1039/C8SC02133C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Biocatalyst–artificial metalloenzyme cascade based on alcohol dehydrogenase
Alcohol dehydrogenase with a dual role: host for metal catalysts and enzyme for ketone reduction.
Chem. Sci., 2018,9, 7447-7454
https://doi.org/10.1039/C8SC02371A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production
Synthetic biology techniques coupled with heterologous secondary metabolite production offer opportunities for the discovery and optimisation of natural products.
Chem. Sci., 2018,9, 7510-7519
https://doi.org/10.1039/C8SC02046A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.
Chem. Sci., 2018,9, 7468-7482
https://doi.org/10.1039/C8SC01482E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
Aptamer conjugated porphyrinic metal–organic framework (MOF) achieved target-induced bioimaging and photodynamic therapy.
Chem. Sci., 2018,9, 7505-7509
https://doi.org/10.1039/C8SC02210K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Hierarchical tandem assembly of planar [3×3] building units into {3×[3×3]} oligomers: mixed-valency, electrical conductivity and magnetism
Electrical conductors are made from flat grid clusters of copper using mixed-valency and supramolecular interactions between the enveloping organic ligands.
Chem. Sci., 2018,9, 7498-7504
https://doi.org/10.1039/C8SC02851F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in Helicobacter pylori on bismuth treatment
Integration of multi-omics analyses uncovers the dynamic responses of H. pylori upon bismuth treatment.
Chem. Sci., 2018,9, 7488-7497
https://doi.org/10.1039/C8SC01668B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(IV) active centers of nano-MOFs
We describe a kind of Zr(IV)-based nano-MOF that is well suited for specific adsorption and selective fluorescence sensing of phosphate based on specific interactions between Zr(IV) and phosphate which provides a new approach for treatment of hyperphosphatemia.
Chem. Sci., 2018,9, 7483-7487
https://doi.org/10.1039/C8SC02638F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism Thermogemmatispora strain T81
Tikitericin, a novel lanthipeptide was isolated and characterised together with its first total synthesis.
Chem. Sci., 2018,9, 7311-7317
https://doi.org/10.1039/C8SC02170H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Facile room temperature synthesis of large graphene sheets from simple molecules
The simplest way to produce large graphene sheets starting from simple molecules (benzene or n-hexane) under ambient conditions (temperature and pressure).
Chem. Sci., 2018,9, 7297-7303
https://doi.org/10.1039/C8SC02818D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation
By successively replacing H+ by Na+ or K+ in phosphopeptide anions and cations, we show that the efficiency of fragmentation into c and z˙ or c˙ and z fragments from N–Cα backbone bond cleavage by negative ion electron capture dissociation (niECD) and electron capture dissociation (ECD) substantially decreases with increasing number of alkali ions attached.
Chem. Sci., 2018,9, 7338-7353
https://doi.org/10.1039/C8SC02470G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.150/content/NewImages/open-access-icon-orange.png)
Reversible coordination of N2 and H2 to a homoleptic S = 1/2 Fe(I) diphosphine complex in solution and the solid state
A 15 valence-electron Fe(I) species rapidly and reversibly binds N2 and H2, the latter producing a rare paramagnetic dihydrogen complex.
Chem. Sci., 2018,9, 7362-7369
https://doi.org/10.1039/C8SC01841C
About this collection
This on-going web collection showcases all of the HOT Chemical Science articles published in 2018, as recommended by referees. Congratulations to all of the authors whose articles are featured.