Themed collection 2022 Chemical Science Perspective & Review Collection
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Chemical tools for study and modulation of biomolecular phase transitions
Chemical tools provide the ability to illuminate and manipulate the behavior of intrinsically disordered proteins and their phase transitions.
Chem. Sci., 2022,13, 14226-14245
https://doi.org/10.1039/D2SC04907D
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Recent advances in the dearomative functionalisation of heteroarenes
This Perspective outlines the myriad of products that can be obtained by the dearomatisation and functionalization of heteroarene substrates. Complex 3D molecules can often be prepared in one step from simple arene starting materials.
Chem. Sci., 2022,13, 14213-14225
https://doi.org/10.1039/D2SC04638E
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Heterometallic bond activation enabled by unsymmetrical ligand scaffolds: bridging the opposites
Unsymmetrical ligand scaffolds bridging two or more different metals in a site-selective manner offer a convenient approach to utilize metal–metal cooperation for bond activation.
Chem. Sci., 2022,13, 14008-14031
https://doi.org/10.1039/D2SC04263K
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Data storage architectures to accelerate chemical discovery: data accessibility for individual laboratories and the community
With the increasing emphasis on data sharing, reproducibility, and replicability, big-data analytics, and machine learning, chemists must consider database management systems for their laboratory's data storage, management, and accessibility.
Chem. Sci., 2022,13, 13646-13656
https://doi.org/10.1039/D2SC05142G
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Multipronged diagnostic and therapeutic strategies for Alzheimer's disease
Decades of research have revealed the multifactorial nature of Alzheimer's disease. We present recent efforts and multipronged approaches to rationally develop reliable diagnostics and therapeutics targeting multiple pathological factors.
Chem. Sci., 2022,13, 13657-13689
https://doi.org/10.1039/D2SC03932J
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Microenvironment engineering of supported metal nanoparticles for chemoselective hydrogenation
Insights on microenvironment engineering for metal nanoparticles using porous materials enriched with organic groups and how it determines the hydrogenation performance through non-covalent interaction are highlighted.
Chem. Sci., 2022,13, 13291-13302
https://doi.org/10.1039/D2SC04223A
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Fluorescence turn-on by photoligation – bright opportunities for soft matter materials
Photochemical ligations that form fluorescent products provide valuable visual feedback for use in biology and material science.
Chem. Sci., 2022,13, 13280-13290
https://doi.org/10.1039/D2SC05403E
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Catalytic ammonia reforming: alternative routes to net-zero-carbon hydrogen and fuel
Ammonia is a promising net-zero-carbon energy vector whose hydrogen content is accessible via multiple catalytic pathways. This perspective highlights advances in NH3 reforming catalysis and opportunities for reaction engineering of reformer devices.
Chem. Sci., 2022,13, 12945-12956
https://doi.org/10.1039/D2SC04672E
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Historical perspective on ruthenium-catalyzed hydrogen transfer and survey of enantioselective hydrogen auto-transfer processes for the conversion of lower alcohols to higher alcohols
Ruthenium-catalyzed hydrogen auto-transfer reactions for the direct enantioselective conversion of lower alcohols to higher alcohols are surveyed. A brief historical perspective on ruthenium-catalyzed hydrogen transfer is given.
Chem. Sci., 2022,13, 12625-12633
https://doi.org/10.1039/D2SC05621F
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Electrokinetic separation techniques for studying nano- and microplastics
This perspective focuses on electrokinetic methods for separating the smallest microplastics (<10 μm) on the basis of charge. Advantages, limitations, and future research opportunities regarding electrokinetic separation methods are discussed.
Chem. Sci., 2022,13, 12616-12624
https://doi.org/10.1039/D2SC04019K
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Light-driven biocatalytic oxidation
Light-driven catalytic cycles by oxidative enzymes, such as peroxygenases, dehydrogenases or monooxygenases, perform a variety of selective oxyfunctionalization and dehydrogenation reactions with or withdrawal of reducing equivalents.
Chem. Sci., 2022,13, 12260-12279
https://doi.org/10.1039/D2SC03483B
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Fabricating sub-nanometer materials through cluster assembly
This perspective discusses the synthesis and precise control of sub-nanometric cluster assemblies at the molecular level, as well as the exceptional properties derived from interactions between clusters.
Chem. Sci., 2022,13, 12280-12289
https://doi.org/10.1039/D2SC03813G
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Deep learning in single-molecule imaging and analysis: recent advances and prospects
Deep learning has been applied in all stages of single molecule imaging and analysis.
Chem. Sci., 2022,13, 11964-11980
https://doi.org/10.1039/D2SC02443H
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Chemistry must respond to the crisis of transgression of planetary boundaries
Chemistry, the science of transformation of matter, is fundamental to achieving sustainability through ensuring biogeochemical flows do not transgress planetary boundaries. This requires urgent changes in chemistry education, research and industry.
Chem. Sci., 2022,13, 11710-11720
https://doi.org/10.1039/D2SC03603G
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Understanding chemistry: from “heuristic (soft) explanations and reasoning by analogy” to “quantum chemistry”
“Soft theories” largely drove chemical understanding for 150 years or more. In the past 50 years, quantum chemistry has provided (a) the underlying “hard evidence” for many soft theories and (b) the explanations for chemical phenomena that are unavailable by soft theories.
Chem. Sci., 2022,13, 11461-11486
https://doi.org/10.1039/D2SC02535C
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Emerging nanosensor platforms and machine learning strategies toward rapid, point-of-need small-molecule metabolite detection and monitoring
Overview of the current status on emerging, multi-faceted nanosensor platform designs and data analysis strategies for rapid, point-of-need detection and monitoring of small-molecule metabolites.
Chem. Sci., 2022,13, 11009-11029
https://doi.org/10.1039/D2SC02981B
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Perspectives on parity violation in chiral molecules: theory, spectroscopic experiment and biomolecular homochirality
The reflection (or ‘mirror’) symmetry of space is among the fundamental symmetries of physics. It is connected to the conservation law for the quantum number purity and its violation and has a fundamental relation to stereochemistry and molecular chirality.
Chem. Sci., 2022,13, 10598-10643
https://doi.org/10.1039/D2SC01323A
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Influence of ion mobility on the redox and catalytic properties of Cu ions in zeolites
The mobility of Cu ions in zeolites is influenced by oxidation state, ligands, zeolite topology and chemical composition. The known and possible implications for catalytic activity of Cu-zeolites are discussed.
Chem. Sci., 2022,13, 10238-10250
https://doi.org/10.1039/D2SC03565K
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Metal–organic frameworks as O2-selective adsorbents for air separations
This Perspective summarizes progress in the development of O2-selective metal–organic frameworks for adsorptive air separations and identifies key metrics and design considerations toward optimizing material performance for practical applications.
Chem. Sci., 2022,13, 10216-10237
https://doi.org/10.1039/D2SC03577D
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Single-molecule magnets beyond a single lanthanide ion: the art of coupling
In this Perspective, we draw a unified picture for single-molecule magnets as delicately coupled spin systems, discuss the hierarchical couplings (from intra-atomic to inter-molecular) and their distinctive impacts on the magnetic behaviours.
Chem. Sci., 2022,13, 8716-8726
https://doi.org/10.1039/D2SC01532C
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Radical transformations for allene synthesis
Recent important advances in the synthesis of allenes via radical strategies are highlighted.
Chem. Sci., 2022,13, 8491-8506
https://doi.org/10.1039/D2SC02573F
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Engendering reactivity at group 5-heteroatom multiple bonds via π-loading
The proof is in the π: when more than one π-donor ligand is bound to a group 5 metal center, imido-based reactivity increases.
Chem. Sci., 2022,13, 8224-8242
https://doi.org/10.1039/D2SC02706B
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Towards the practical application of Zn metal anodes for mild aqueous rechargeable Zn batteries
This perspective article focuses on discussing several “less-developed” but important topics for Zn anodes and try to present readers a practical angle to look at the development of aqueous Zn batteries.
Chem. Sci., 2022,13, 8243-8252
https://doi.org/10.1039/D2SC01818G
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From computational high-throughput screenings to the lab: taking metal–organic frameworks out of the computer
Computational high-throughput screenings (HTS) have become a standard method of sieving the vast amount of metal–organic frameworks (MOFs) data. But not many HTS studies have been able to bring MOFs to the lab.
Chem. Sci., 2022,13, 7990-8002
https://doi.org/10.1039/D2SC01254E
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Ensemble representation of catalytic interfaces: soloists, orchestras, and everything in-between
Catalytic systems are complex and dynamic, exploring vast chemical spaces on multiple timescales.
Chem. Sci., 2022,13, 8003-8016
https://doi.org/10.1039/D2SC01367C
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Electronic structure of strongly correlated systems: recent developments in multiconfiguration pair-density functional theory and multiconfiguration nonclassical-energy functional theory
This feature article overviews recent work on active spaces, matrix product reference states, treatment of quasidegeneracy, hybrid theory, density-coherence functionals, machine-learned functionals, spin–orbit coupling, gradients, and dipole moments.
Chem. Sci., 2022,13, 7685-7706
https://doi.org/10.1039/D2SC01022D
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Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids
Small molecule contaminants pose a significant threat to the environment and human health.
Chem. Sci., 2022,13, 7670-7684
https://doi.org/10.1039/D2SC00117A
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Activation of Si–H and B–H bonds by Lewis acidic transition metals and p-block elements: same, but different
In this Perspective we compare the ability of transition metals and p-block Lewis acids to activate electrophilically hydrosilanes and hydroboranes. The mechanistic similarities and dissimilarities in different catalytic transformations are analyzed.
Chem. Sci., 2022,13, 7392-7418
https://doi.org/10.1039/D2SC02324E
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Molecular mechanisms of amyloid formation in living systems
The molecular mechanisms of amyloid formation have been studied extensively in test tube reactions. This perspective article addresses the question to what extent these mechanisms apply to the complex situation in living cells and organisms.
Chem. Sci., 2022,13, 7080-7097
https://doi.org/10.1039/D2SC01278B
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Tin-based halide perovskite materials: properties and applications
This perspective presents the current status and prospects of tin-perovskites and the relevant optoelectronic device applications.
Chem. Sci., 2022,13, 6766-6781
https://doi.org/10.1039/D2SC01914K
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Catalytic approaches towards highly durable proton exchange membrane fuel cells with minimized Pt use
Catalytic approaches to enhance PEMFC performances are introduced, especially focusing on the studies reporting MEA cell data.
Chem. Sci., 2022,13, 6782-6795
https://doi.org/10.1039/D2SC00541G
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Next steps for solvent-based CO2 capture; integration of capture, conversion, and mineralisation
In this perspective, we detail how solvent-based carbon capture integrated with conversion can be an important element in a net-zero emission economy.
Chem. Sci., 2022,13, 6445-6456
https://doi.org/10.1039/D2SC00220E
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Advancing global chemical education through interactive teaching tools
This perspective highlights the development of interactive chemical education resources for worldwide usage. We hope to promote a spirit of innovation in chemical education and spur the development of new chemical education resources.
Chem. Sci., 2022,13, 5790-5796
https://doi.org/10.1039/D2SC01881K
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Sulfur-bridged chromophores for photofunctional materials: using sulfur oxidation state to tune electronic and structural properties
In this perspective, the effect of different oxidation states in sulfur-bridged bichromophoric systems on structural, photochemical and photophysical properties in organic and coordination compounds is explored.
Chem. Sci., 2022,13, 5447-5464
https://doi.org/10.1039/D2SC01128J
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Oriented internal electrostatic fields: an emerging design element in coordination chemistry and catalysis
Internal electrostatic field effects are poised to play a major role in the design of molecular coordination complexes and catalysts.
Chem. Sci., 2022,13, 5432-5446
https://doi.org/10.1039/D2SC01715F
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Porous liquids – the future is looking emptier
The realisation of permanent microporosity in liquids transforms the way functional porosity may be implemented. Considering recent advances, we explore the developing theory of porous liquids and delve into the discovery process and applications.
Chem. Sci., 2022,13, 5042-5054
https://doi.org/10.1039/D2SC00087C
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Machine learning potential era of zeolite simulation
The machine learning atomic simulation will usher the research of zeolite, as other complex materials, into a new era featuring the easy access to zeolite functionalities predicted from theory.
Chem. Sci., 2022,13, 5055-5068
https://doi.org/10.1039/D2SC01225A
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Reductive aminations by imine reductases: from milligrams to tons
IRED-catalyzed reductive aminations have progressed from mg to ton scale, through advances in enzyme discovery, protein engineering and process biocatalysis.
Chem. Sci., 2022,13, 4697-4713
https://doi.org/10.1039/D2SC00124A
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Machine learning for flow batteries: opportunities and challenges
A fundamental workflow of ML in flow batteries and recent progress of the state-of-art ML applications in both organic FBs and vanadium FBs are discussed. The challenges and future directions of ML research in FBs are proposed.
Chem. Sci., 2022,13, 4740-4752
https://doi.org/10.1039/D2SC00291D
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On the interface reactions and stability of nonfullerene organic solar cells
Interface instability of emerging nonfullerene organic solar cells has been discussed, with respect to the phenomena, mechanism of interfacial reactions and strategies proposed to improve the interfacial stability of devices.
Chem. Sci., 2022,13, 4714-4739
https://doi.org/10.1039/D1SC07269B
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Mechanically interlocked molecular handcuffs
Mechanically interlocked molecules that employ a handcuff component provide a pathway to highly unusual structures, a new nomenclature is proposed which helps to identify opportunities for employing this structural unit for new architectures.
Chem. Sci., 2022,13, 3915-3941
https://doi.org/10.1039/D2SC00568A
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Distinctive features and challenges in catenane chemistry
Catenane chemistry is closely associated with that of rotaxane and knot, and this perspective highlights their similarities and differences in various aspects including synthesis, structure and properties.
Chem. Sci., 2022,13, 3315-3334
https://doi.org/10.1039/D1SC05391D
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Bottom-up supramolecular assembly in two dimensions
The self-assembly of molecules in two dimensions (2D) is gathering attention from all disciplines across the chemical sciences. This perspective discusses the main strategies to direct the supramolecular self-assembly of organic monomers in 2D.
Chem. Sci., 2022,13, 3057-3068
https://doi.org/10.1039/D1SC05667K
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Bridging electrocatalyst and cocatalyst studies for solar hydrogen production via water splitting
This perspective briefly reviews recently developed water splitting electrocatalyst materials and discusses their utilization as cocatalysts for photocatalytic and photoelectrochemical water splitting systems.
Chem. Sci., 2022,13, 2824-2840
https://doi.org/10.1039/D1SC06015E
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Umpolung strategies for the functionalization of peptides and proteins
This perspective highlights the growing body of literature that leverages polarity reversal (umpolung reactivity) for the selective modification of proteinogenic functionalities and identifies opportunities for further innovation.
Chem. Sci., 2022,13, 2809-2823
https://doi.org/10.1039/D1SC06133J
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Polyoxometalates as chemically and structurally versatile components in self-assembled materials
Polyoxometalates are anionic molecular metal oxides with diversity in composition, structure, nuclearity and charge. Their adaptable chemistry leads to potential for self-assembly with other building blocks into a variety of hybrid structures.
Chem. Sci., 2022,13, 2510-2527
https://doi.org/10.1039/D1SC05879G
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Development of formamidinium lead iodide-based perovskite solar cells: efficiency and stability
This perspective is focused on the current development state and the future development direction of FA-based perovskite materials and solar cells.
Chem. Sci., 2022,13, 2167-2183
https://doi.org/10.1039/D1SC04769H
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Can super-resolution microscopy become a standard characterization technique for materials chemistry?
SRM, an advanced nanoscopy technique demands a transition from being a niche sophisticated technique to standard routine method for material characterization. The roadmap of necessary developments through multidisciplinary collaboration is discussed.
Chem. Sci., 2022,13, 2152-2166
https://doi.org/10.1039/D1SC05506B
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Functionalised nanopores: chemical and biological modifications
The convergence of chemistry, biology, and solid-state approaches enables the construction hybrid nanopores with enhanced single-molecule applications.
Chem. Sci., 2022,13, 1869-1882
https://doi.org/10.1039/D1SC05766A
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Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy
UCNPs can convert the long wavelength of light to UV-Vis light for the controlled gas release owing to their unique upconversion luminescence (UCL) ability. This review summarized the recent progress of UCNP-based nanocomposites in gas therapy.
Chem. Sci., 2022,13, 1883-1898
https://doi.org/10.1039/D1SC04413C
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Natural product drug discovery in the artificial intelligence era
Natural products (NPs) are primarily recognized as privileged structures to interact with protein drug targets.
Chem. Sci., 2022,13, 1526-1546
https://doi.org/10.1039/D1SC04471K
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Engineering and characterization of interphases for lithium metal anodes
Different strategies of SEI engineering such as modification, additive application, and artificial SEI for electrolyte are summarized. Characterization techniques for SEI studies using X-ray, neutron, and electron as probing beams are discussed.
Chem. Sci., 2022,13, 1547-1568
https://doi.org/10.1039/D1SC06181J
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Asymmetric transformations from sulfoxonium ylides
Asymmetric transformations involving sulfoxonium ylides, culminating in catalytic enantioselective versions, are discussed in this perspective.
Chem. Sci., 2022,13, 1192-1209
https://doi.org/10.1039/D1SC05708A
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Defect engineering in semiconductor-based SERS
Defect engineering strategies are used to boost the SERS activity of a wide variety of semiconductors including metal oxides, nitrides, carbon materials and transition metal dichalcogenides (TMDs), as discussed in this perspective.
Chem. Sci., 2022,13, 1210-1224
https://doi.org/10.1039/D1SC05940H
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Facilitating green ammonia manufacture under milder conditions: what do heterogeneous catalyst formulations have to offer?
The transition to green ammonia is necessary, but conventional catalysts perform poorly under ‘green’ reaction conditions. We provide a perspective on the recent progress in developing more efficient catalysts for lower temperatures and pressures.
Chem. Sci., 2022,13, 890-908
https://doi.org/10.1039/D1SC04734E
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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
Recent advances in cancer chemodynamic therapy based on Fenton chemistry are reviewed, including the working mechanism, characteristics, and strategies for optimizing treatment efficiency.
Chem. Sci., 2022,13, 863-889
https://doi.org/10.1039/D1SC05482A
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Janus 2D materials via asymmetric molecular functionalization
The asymmetric molecular functionalization of two-dimensional materials on one (supratopic) or both (antaratopic) faces enables the design of new multifunctional Janus materials for applications in opto-electronics, energy storage, and catalysis.
Chem. Sci., 2022,13, 315-328
https://doi.org/10.1039/D1SC05836C
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Improving the intrinsic activity of electrocatalysts for sustainable energy conversion: where are we and where can we go?
We evaluate the improvements over the past two decades in intrinsic activity of electrocatalysts for sustainable energy conversion, and highlight opportunities from tuning the electrolyte.
Chem. Sci., 2022,13, 14-26
https://doi.org/10.1039/D1SC04775B
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Generation of organo-alkaline earth metal complexes from non-polar unsaturated molecules and their synthetic applications
In this perspective, we highlight the recent development of metallation protocols of non-polar unsaturated molecules for the generation of organo-alkaline earth metal compounds and their applications in chemical synthesis and catalysis.
Chem. Sci., 2022,13, 27-38
https://doi.org/10.1039/D1SC05724C
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Anode optimization strategies for aqueous zinc-ion batteries
This review provides a comprehensive summary of the research progress of Zn anodes, including the main challenges of Zn metal anodes, the corresponding optimization strategies, and the perspectives for practical aqueous Zn-ion batteries.
Chem. Sci., 2022,13, 14246-14263
https://doi.org/10.1039/D2SC04945G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Recent progress on MOF-based optical sensors for VOC sensing
MOF-based optical sensors can achieve volatile organic compound sensing via different mechanisms: colorimetric sensing, luminescent sensing and optical-index modulation sensing.
Chem. Sci., 2022,13, 13978-14007
https://doi.org/10.1039/D2SC04314A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Sonopharmacology: controlling pharmacotherapy and diagnosis by ultrasound-induced polymer mechanochemistry
Ultrasound is an important tool for diagnostic and therapeutic purposes in the clinic. We here survey recent efforts to exploit the principles of polymer mechanochemistry for ultrasound-guided drug delivery and activation – sonopharmacology.
Chem. Sci., 2022,13, 13708-13719
https://doi.org/10.1039/D2SC05196F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Organothianthrenium salts: synthesis and utilization
This review summarizes the synthesis of diverse organothianthrenium salts from various precursors and their applications in organic synthesis to forge new C–C, C–H and C–heteroatom bonds by C–S bond cleavage with different mechanistic considerations.
Chem. Sci., 2022,13, 13690-13707
https://doi.org/10.1039/D2SC04507A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Mesoporous ordered films via self-assembly: trends and perspectives
Mesoporous ordered films, from self-assembly to advanced applications.
Chem. Sci., 2022,13, 13264-13279
https://doi.org/10.1039/D2SC04828K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Imaging strategies for monitoring the immune response
Immune-related imaging strategies, current problems and development direction are summarized and discussed in this paper.
Chem. Sci., 2022,13, 12957-12970
https://doi.org/10.1039/D2SC03446H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
The way to AI-controlled synthesis: how far do we need to go?
It is still a long march for AI-controlled synthesis to enter into general laboratories. Flaws in the architecture of AI-controlled synthesis systems must be overcome.
Chem. Sci., 2022,13, 12604-12615
https://doi.org/10.1039/D2SC04419F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Multi-analyte sensing strategies towards wearable and intelligent devices
Continuous efforts to produce functional nanomaterials and flexible/stretchable devices have promoted cumbersome, laboratorial, detection processes toward wearable and portable intelligent sensing approaches.
Chem. Sci., 2022,13, 12309-12325
https://doi.org/10.1039/D2SC03750E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Recent advances in metal-catalysed asymmetric sigmatropic rearrangements
Catalytic asymmetric sigmatropic rearrangements induced by chiral metal catalysis have been intensively explored. This review summarizes recent significant advances, mainly involving [3,3], [2,3] and [1,3]-rearrangements.
Chem. Sci., 2022,13, 12290-12308
https://doi.org/10.1039/D2SC03806D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Metal–organic frameworks and their derivatives for metal-ion (Li, Na, K and Zn) hybrid capacitors
This review summarizes the progress of metal–organic frameworks and their derivatives as advanced multifunctional platforms for metal-ion hybrid capacitors.
Chem. Sci., 2022,13, 11981-12015
https://doi.org/10.1039/D2SC04012C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Bicyclobutanes: from curiosities to versatile reagents and covalent warheads
A flurry of reports for preparing, functionalizing, and using bicyclo[1.1.0]butanes (BCBs) have positioned them to be powerful synthons with numerous applications. This review discusses the recent developments regarding this strained carbocycle.
Chem. Sci., 2022,13, 11721-11737
https://doi.org/10.1039/D2SC03948F
About this collection
This web collection showcases all of the Perspective and Review articles published in Chemical Science in 2022.