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Themed collection Responsive Materials for Healthcare Diagnostics

15 items
Editorial

Introduction to responsive materials for healthcare diagnostics

Marek W. Urban introduces the Journal of Materials Chemistry B themed issue on responsive materials for healthcare diagnostics.

Graphical abstract: Introduction to responsive materials for healthcare diagnostics
Highlight

Understanding the fate of DNA nanostructures inside the cell

DNA nanostructures are highly tunable and responsive materials for diagnostic and healthcare-related applications, but their intracellular fate remains largely unknown.

Graphical abstract: Understanding the fate of DNA nanostructures inside the cell
From the themed collection: Journal of Materials Chemistry B HOT Papers
Open Access Perspective

The rise of bio-inspired polymer compartments responding to pathology-related signals

Self-organized nano- and microscale polymer compartments such as polymersomes, giant unilamellar vesicles (GUVs), polyion complex vesicles (PICsomes) and layer-by-layer (LbL) capsules have increasing potential in many sensing applications.

Graphical abstract: The rise of bio-inspired polymer compartments responding to pathology-related signals
From the themed collection: Recent Open Access Articles
Review Article

Stimuli-responsive polymer-based systems for diagnostic applications

The unique properties of stimuli-responsive polymers make them valuable for myriad applications, their use for biosensing and molecular diagnostics is reviewed here.

Graphical abstract: Stimuli-responsive polymer-based systems for diagnostic applications
Review Article

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

Wound healing microphysiological systems have been engineered with synthetic and natural materials and techniques such as bioprinting or viscous finger patterning. Model designs focus on particular phases of wound healing or the recapitulation of micro-anatomies.

Graphical abstract: Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies
Review Article

Single plasmonic nanostructures for biomedical diagnosis

This work discusses prominent advantages and advances in single-nanoparticle characterization and synthesis, and gives an outlook on particle-based biomedical diagnosis.

Graphical abstract: Single plasmonic nanostructures for biomedical diagnosis
Review Article

Responsive polymers for medical diagnostics

Stimulus-responsive polymers have been used in improving the efficacy of medical diagnostics through different approaches including enhancing the contrast in imaging techniques and promoting the molecular recognition in diagnostic assays.

Graphical abstract: Responsive polymers for medical diagnostics
Review Article

Design principles and fundamental understanding of biosensors for amyloid-β detection

Aβ as biomarker in Alzheimer’s disease (AD) drives the significant research efforts for developing different biosensors with different sensing strategies, materials, and mechanisms for Aβ detection.

Graphical abstract: Design principles and fundamental understanding of biosensors for amyloid-β detection
Open Access Review Article

Smart diagnostic nano-agents for cerebral ischemia

A summary of the latest developments on imaging techniques and smart nano-diagnostics used for ischemic stroke.

Graphical abstract: Smart diagnostic nano-agents for cerebral ischemia
From the themed collection: Recent Open Access Articles
Open Access Communication

Single-molecule DNA origami aptasensors for real-time biomarker detection

DNA nanostructures as platforms to monitor the inherent conformational changes of aptamers upon analyte binding, with single-molecule resolution and real-time capability.

Graphical abstract: Single-molecule DNA origami aptasensors for real-time biomarker detection
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers

We used osmotic pressure changes to induce shape transformation in glassy polymersomes from crosslinkable ABA triblock copolymers. We observed that both the speed of osmotic pressure changes and order of crosslinking affect shape change behavior.

Graphical abstract: Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers
Paper

Core–shell nanoparticles as platform technologies for paper based point-of-care devices to detect antimicrobial resistance

Development of instrument-free point-of-care devices comprising of core-shell nanoparticles as platform technology to make paper based device for detection of antimicrobial resistance in sample.

Graphical abstract: Core–shell nanoparticles as platform technologies for paper based point-of-care devices to detect antimicrobial resistance
Paper

Real-time and label-free detection of VKORC1 genes based on a magnetoelastic biosensor for warfarin therapy

This work describes the design of a magnetoelastic biosensor to detect VKORC1 genes for warfarin therapy in a fast, label-free and sensitive manner.

Graphical abstract: Real-time and label-free detection of VKORC1 genes based on a magnetoelastic biosensor for warfarin therapy
Open Access Paper

Liquid crystal elastomers as substrates for 3D, robust, implantable electronics

Liquid crystal elastomers are used as substrates for robust, implantable electronics that are planar processed then morph into 3D shapes.

Graphical abstract: Liquid crystal elastomers as substrates for 3D, robust, implantable electronics
From the themed collection: Recent Open Access Articles
Paper

Lipid-based lyotropic liquid crystalline phase transitions as a novel assay platform using birefringence as the visual signal output

Digestible amphiphilic lipids offer an opportunity to use birefringence of self-assembled lipid phases as a signal for a new class of electronics-free and colour-free visual biosensor.

Graphical abstract: Lipid-based lyotropic liquid crystalline phase transitions as a novel assay platform using birefringence as the visual signal output
15 items

About this collection

Guest edited by Dr Gemma-Louise Davies (University College London) and Professor Marek W Urban (Clemson University).

Stimuli-responsive materials have become popular in materials chemistry in recent years, towards applications in biosensing, on-demand drug delivery, tissue generation, and smart coatings. In particular, such materials have enormous potential for medical diagnostics, for lab-on-a chip or in vivo identification and diagnosis of disease. New materials, based on inorganic complexes, organic ligands, polymers and multifunctional nanostructures, have demonstrated intriguing properties capable of changing or ‘switching’ signal in the presence of an environmental stimulus indicative of disease, providing a unique approach to positive diagnosis.

This Themed Issue in Journal of Materials Chemistry B aims to explore the latest developments in the design, preparation, novel function and application of materials for healthcare diagnostics.

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