Issue 29, 2020

Smart diagnostic nano-agents for cerebral ischemia


Cerebral ischemia (or ischemic stroke) is undeniably one of the most important life-threatening cerebral disorders. It occurs due to a clot formation in one of the blood arteries supplying the brain, causing a reduction or interruption of the blood flow. To date, the use of thrombolytics like the recombinant tissue plasminogen activator or the use of mechanical thrombectomy are the only two food and drug administration-approved treatments. However, these cannot be applied without first evaluating the beneficial or adverse effects on the patient. Thus, imaging is decisive for identifying the appropriateness of each stroke patient, leading potentially to improved therapeutic outcomes. In this review, we will present a variety of diagnostic nano-agents, and a few theranostic ones, for the assessment of ischemic stroke, highlighting their strengths and weaknesses.

Graphical abstract: Smart diagnostic nano-agents for cerebral ischemia

Article information

Article type
Review Article
29 Jan 2020
26 Feb 2020
First published
26 Feb 2020
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2020,8, 6233-6251

Smart diagnostic nano-agents for cerebral ischemia

C. Tapeinos, M. Battaglini, A. Marino and G. Ciofani, J. Mater. Chem. B, 2020, 8, 6233 DOI: 10.1039/D0TB00260G

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