Themed collection Journal of Materials Chemistry B HOT Papers
Nanoparticle-mediated surfactant therapy in patients with severe COVID-19: a perspective
Nanoparticle-mediated surfactant therapy in patients with severe COVID-19.
Gas and gas-generating nanoplatforms in cancer therapy
Gas-generating nanoplatforms have promising therapeutic potential for cancer treatment.
SARS-CoV-2 and approaches for a testing and diagnostic strategy
The COVID-19 pandemic has led to an unprecedented global health challenge, creating sudden, massive demands for diagnostic testing, treatment, therapies, and vaccines.
Nanotechnology lights up the antitumor potency by combining chemotherapy with siRNA
This review summarizes the latest nanosystems with different functional nanomaterials that co-load and protect the siRNA/drugs, precisely target tumors, and release cargoes intelligently.
Superoxide dismutase nanozymes: an emerging star for anti-oxidation
This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes.
Bringing naturally-occurring saturated fatty acids into biomedical research
This review introduces naturally-occurring saturated fatty acids (NSFAs) and their biomedical applications, including controlled drug release, targeted drug delivery, cancer therapy, antibacterial treatment, and tissue engineering.
Hyaluronic acid-based hydrogels to study cancer cell behaviors
Hyaluronic acid (HA) based hydrogels can be fabricated using various chemistries to study cancer cell behaviors in vitro.
2D materials as a diagnostic platform for the detection and sensing of the SARS-CoV-2 virus: a bird's-eye view
This article reviews the use of two-dimensional materials as diagnostic platforms for the detection and sensing of the SARS-CoV-19 virus.
Magnetic nanocomplexes for gene delivery applications
This review paper covers the recent progress of magnetic nanoparticles (MNP)-based gene delivery. Cutting-edge applications of MNP-based gene delivery on cancer therapy, neural repairing, regenerative medicine and gene editing are also introduced.
Tissue adhesive hydrogel bioelectronics
This review describes the recent progress in tissue adhesive hydrogel bioelectronics.
Nanoscale metal–organic frameworks for tumor phototherapy
Nanoscale metal–organic frameworks (NMOFs) based on different metal ions for phototherapy.
Biomaterial-based physical regulation of macrophage behaviour
Macrophages respond to physical stimuli of biomaterials, including stiffness, topography and confinement. Understanding the mechanical regulation of macrophage behaviour provides insights for biomaterial design.
Recent advances in thermo-sensitive hydrogels for drug delivery
Thermo-sensitive hydrogels based on different polymers have been broadly used in the pharmaceutical fields. In this review, the state-of-the-art thermo-sensitive hydrogels for drug delivery are elaborated
Multifunctional conductive hydrogels and their applications as smart wearable devices
Multifunctional conductive hydrogels with representative preparation strategies and related properties.
Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases
This review summarizes the research works of non-enzymatic electrochemical sensors for the early diagnosis of Neurodegenerative disease.
Mesoporous TiO2-based architectures as promising sensing materials towards next-generation biosensing applications
This review highlights the recent development of mesoporous TiO2-based architectures as promising sensing materials for diagnosing diseases and detecting harmful substances in the human body.
The study and application of biomolecules in deep eutectic solvents
Deep eutectic solvents offer stimulating possibilities for biomolecular stabilization and manipulation, biocatalysis, bioextraction, biomass processing, and drug delivery and therapy.
A review on hydroxyapatite coatings for the biomedical applications: experimental and theoretical perspectives
The production of hydroxyapatite (HAP) composite coatings has continuously been investigated for bone tissue applications during the last few decades due to their significant bioactivity and osteoconductivity.
Metal–ligand coordination nanomaterials for radiotherapy: emerging synergistic cancer therapy
This review summarizes the recent advances in metal-ligand coordination nanomaterials-mediated synergistic radiotherapy with a emphasis focusing upon constructive strategies for radiosensitive nanoplatform and underlying synergistic mechanism.
Citrate-based mussel-inspired magnesium whitlockite composite adhesives augmented bone-to-tendon healing
Citrate-based mussel-inspired magnesium whitlockite composite adhesives were developed to augment bone-to-tendon healing, by providing interface adhesion, promoting bony inward growth from the bone tunnel, and enhancing chondrogenesis and osteogenesis of the bone–tendon interface.
Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers
Core–shell tecto dendrimers with improved core rigidity can be synthesized using phosphorus dendrimers as cores for enhanced gene delivery applications.
A robust CRISPR–Cas12a biosensor coated with metal–organic framework
A protective coating strategy based on metal–organic frameworks (MOFs) has been proposed to preserve the bioactivity of the Cas12a/crRNA complex.
Hemoglobin coated oxygen storage metal–organic framework as a promising artificial oxygen carrier
A novel oxygen carrier with excellent oxygen storage capacity and sustained release ability has been synthesized. This hybrid may have potential to be developed as useful artificial oxygen carriers in the future.
Charge-reversal silver clusters for targeted bacterial killing
Ag(−)/Ag(+) clusters with negatively charged nanoparticles and big-size are transformed into positively charged nanoparticles with small size in a bacterial acidic environment to kill the bacteria effectively.
Zwitterionic choline phosphate conjugated folate-poly (ethylene glycol): a general decoration of erythrocyte membrane-coated nanoparticles for enhanced tumor-targeting drug delivery
A general decoration of erythrocyte membrane-coated nanoparticles for enhanced tumor-targeting drug delivery based on the “CP–PC” interaction of MCP-PEG-FA and erythrocyte membranes.
Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles
An investigation of how the LogP value of an active controls the formation of lipid-based nanoparticles. Hydrophobically-modified drug analogues were formulated to give nanoparticles with much higher drug loadings than conventional lipid nanocarriers.
Synergic influences of network topologies and associative interactions on the microstructures and bulk performances of hydrogels
We develop hydrogels with constant composition yet different network topologies, which result in hydrogen-bond associations of different strengths and densities, as well as distinct microstructures and properties of the gels.
Microenvironment-responsive multifunctional hydrogels with spatiotemporal sequential release of tailored recombinant human collagen type III for the rapid repair of infected chronic diabetic wounds
A brand-new tailored hCol III-based microenvironment-responsive hydrogel could effectively accelerate the repair and regeneration of chronic diabetic wounds by a programmed controlled release of therapeutic substance approach.
In situ construction of a nano-structured akermanite coating for promoting bone formation and osseointegration of Ti–6Al–4V implants in a rabbit osteoporosis model
In situ construction of nano-structured akermanite (nAK) coatings on Ti–6Al–4V implants and their promotion for osteogenesis and osseointegration in osteoporosis.
Facile synthesis of near-infrared bodipy by donor engineering for in vivo tumor targeted dual-modal imaging
The impact of donor strength on Bodipys’ optical properties and its applications for tumor near-infrared fluorescence imaging and photoacoustic tomography.
131I-Labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer
Radionuclide 131I-labeled gold nanoframeworks (131I-AuNFs) are developed for radiotherapy-combined second near-infrared photothermal therapy of breast cancer.
Defective Ag–In–S/ZnS quantum dots: an oxygen-derived free radical scavenger for mitigating macrophage inflammation
The as-prepared defective AIS/ZnS QDs have favorable oxygen-derived free radical scavenging abilities in vitro and exhibit benign anti-inflammatory activities in the model of lipopolysaccharide (LPS)-induced inflammation in macrophages.
Photothermally responsive Pickering emulsions stabilised by polydopamine nanobowls
In this study, polydopamine mesoporous nanobowls stabilise photothermally responsive oil-in water Pickering emulsions. Prepared emulsions show excellent photothermal efficiency under near-infrared (NIR) illumination, offering potential in NIR triggered drug release.
A multifunctional targeted nanoprobe with high NIR-II PAI/MRI performance for precise theranostics of orthotopic early-stage hepatocellular carcinoma
A novel GPC-3-targeted multifunctional nanoprobe for precise theranostics of orthotopic early-stage hepatocellular carcinoma was developed via dual-modal photoacoustic/magnetic resonance imaging and imaging guided non-invasive photothermal therapy.
Selective and stoichiometric incorporation of ATP by self-assembling amyloid fibrils
The merger of insulin's amyloidogenic segment and an octalysine stretch produces a chimeric peptide with the ability to bind and incorporate stoichiometric amounts of ATP upon co-aggregation and formation of amyloid fibrils.
Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy
A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting T1-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI).
A non-peptide probe for detecting chymotrypsin activity based on protection–deprotection strategy in living systems
A non-peptide probe for detecting chymotrypsin activity based on a protection–deprotection strategy in living systems.
Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference
An electrochemical non-enzymatic sensor based on a NiVP/Pi material was developed for the selective and sensitive determination of glucose.
A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy
Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.
A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury
Visualizing ONOO− fluctuations in the complex drug-induced acute liver injury process using a ratiometric fluorescent probe developed by using a molecular hybridization strategy with high selectivity and sensitivity.
A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles
In this study, we aimed to achieve an efficient repair of damaged skeletal muscles using polyvinyl alcohol (PVA) soluble microneedle patches (MNP) loaded with carbonized wormwood and prostaglandin E2 (inflammatory factors).
The role of micro-vibration parameters in inflammatory responses of macrophages cultured on biphasic calcium phosphate ceramics and the resultant influence on osteogenic differentiation of mesenchymal stem cells
Micro-vibration stimulation (MVs) plays a critical role in regulating the inflammatory responses of macrophages to BCP ceramics and further inducing the osteogenic differentiation of BMMSCs in a paracrine manner.
A multidimensional biosensor system to guide LUAD individualized treatment
We report a multidimensional biosensor system to guide adenocarcinoma individualized treatment by integrating 2D and 3D PDC models and novel cellular impedance biosensors. The strategy may contribute to individualized treatment and drug development.
Poly(vinyl alcohol-co-itaconic acid) hydrogels grafted with several designed peptides for human pluripotent stem cell culture and differentiation into cardiomyocytes
Human pluripotent stem cells can be successfully cultured on hydrogels grafted with laminin-β4 peptide having appropriate ζ potential, which have a joint segment, dual chain motif, and cationic amino acid insertion.
Mesoporous polydopamine-coated hydroxyapatite nano-composites for ROS-triggered nitric oxide-enhanced photothermal therapy of osteosarcoma
A multifunctional therapeutic nanoplatform for ROS-triggered NO-enhanced photothermal therapy of osteosarcoma.
Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model
The in vivo porcine carotid artery replacement studies showed that bivalirudin (BVLD) and REDV co-modified ePTFE vascular grafts could maintain ideal patency and realize endothelialization on the luminal surface at 12 weeks after implantation.
Delivery of a system xc− inhibitor by a redox-responsive levodopa prodrug nanoassembly for combination ferrotherapy
A ferroptosis nano-prodrug (SSZ–Fe2+@DSSD) that can generate intercellular ROS and inhibit the system xc−-GSH-GPX4 pathway to enhance the cancer ferrotherapy.
Molecule-specific vibration-based chiral differentiation of Raman spectra using cysteine modified gold nanoparticles: the cases of tyrosine and phenylalanine
The chirality of amino acids plays a key role in many biochemical processes, with the development of spectroscopic analysis methods for the chiral differentiation of amino acids being significant.
Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties
Tannic acid cross-linked dynamic hydrogels hybridized with tannic acid reduced silver nanoparticles shows multi-functional properties including dual stimuli responsive drug release, anti-bacterial and anti-reactive oxygen species abilities.
Graphene-coated copper-doped ZnO quantum dots for sensitive photoelectrochemical bioanalysis of thrombin triggered by DNA nanoflowers
This work reports a photoelectrochemical biosensing platform for thrombin using graphene oxide-coated copper-doped zinc oxide quantum dots as the photoactive materials and glucose oxidase-encapsulated DNA nanoflowers for signal amplification.
Urate oxidase loaded in PCN-222(Fe) with peroxidase-like activity for colorimetric detection of uric acid
A simple uric acid detection method is successfully developed through the integration of urate oxidase (UOx) and PCN-222(Fe) with peroxidase-like activity.
Facile synthesis of biocompatible magnetic titania nanorods for T1-magnetic resonance imaging and enhanced phototherapy of cancers
The designed Pluronic® F-127 coated Fe–TiO2 NCs promote the growth of intestine organoids, demonstrate remarkable T1 contrast in MRI and significant photodynamic therapy of breast cancer at very low UV power (2.5 mW cm−2).
Bioorthogonal chemistry in metal clusters: a general strategy for the construction of multifunctional probes for bioimaging in living cells and in vivo
Bioorthogonal chemistry in metal clusters: a new strategy for the preparation of modular multifunctional probes based on the bioorthogonal reaction system is presented.
Effects of bioactive strontium-substituted hydroxyapatite on osseointegration of polyethylene terephthalate artificial ligaments
The insufficient bioactivity of PET artificial ligaments severely weakens the ligament-bone healing in ACL reconstruction, while osteogenic modification is a prevailing method to enhance osseointegration of PET artificial ligaments.
Substance P containing peptide gene delivery vectors for specifically transfecting glioma cells mediated by a neurokinin-1 receptor
Gene therapy provides a promising treatment for glioblastoma multiforme, which mainly depends on two key aspects, crossing the blood brain barrier (BBB) effectively and transfecting target cells selectively.
Fabricating a wettable microwells array onto a nitrogen plasma-treated ITO substrate: high-throughput fluorimetric platform for selective sensing of ammonia in blood using polymer-stabilized NH2-MIL-125
Fluorescent NH2-MIL-125 encapsulated in a polymer was coated into wettable microwells array for the sensing of NH3, and demonstrated a target enrichment capability and enhanced responses.
A novel theranostic nanoplatform for imaging-guided chemo-photothermal therapy in oral squamous cell carcinoma
We constructed the PDA-modified HATb nanoparticle encapsulating the anticancer drug DOX (HATb-PDA-DOX), which achieved pH/NIR triggered drug release and imaging-guided synergistic chemo-photothermal tumor therapy.
A zwitterionic polypeptide nanocomposite with unique NIR-I/II photoacoustic imaging for NIR-I/II cancer photothermal therapy
We put forward an innovative strategy to construct a zwitterionic polypeptide nanocomposite which mediated unique NIR-I/II PAI and NIR-II PTT to completely eradicate MCF-7 tumors in vivo. This study will accelerate the polypeptide nanomedicine for clinical transition.
Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction
A facile and mild polydopamine (PDA) and poly(ethylene glycol) (PEG) coating strategy is reported for hydrophilic and anti-adhesive modification of porous polymer MNs from a phase inversion method.
Antimicrobial and degradable triazolinedione (TAD) crosslinked polypeptide hydrogels
Controlling molecular weight, crosslink density and chirality in covalent polypeptide hydrogels allows the independent tuning of rheological, water uptake, degradation and antimicrobial properties.
An electrochemical biosensing platform for progesterone hormone detection using magnetic graphene oxide
A facile and label-free electrochemical approach based on magnetic graphene oxide nanomaterials with a large surface to volume ratio and less susceptible to aggregation proved promising in developing highly sensitive and selective sensing of progesterone.
Oxygen-producing proenzyme hydrogels for photodynamic-mediated metastasis-inhibiting combinational therapy
An oxygen-producing proenzyme hydrogel with near-infrared photoactivatable enzymatic activity was developed for photodynamic therapy enabled metastasis-inhibiting combinational therapy of breast cancer.
Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study
Bimodal sub-5 nm superparamagnetic iron oxide nanoparticles (SPIO-5) coated with polyethylene glycol of different chain lengths (i.e. PEG-800, -2000 and -5000) have been prepared and characterized.
Carbonized zein nanosheets with intrinsic enzyme-mimicking activities and high photothermal conversion efficiency for synergistic cancer therapy
A facile and economic method to fabricate N-rich carbon nanozyme is presented by using zein as a precursor. This material possesses intrinsic oxidase- and peroxidase-like activities, and can be applied as a robust agent for cancer treatment.
Cascade catalytic nanoplatform constructed by laterally-functionalized pillararenes for antibacterial chemodynamic therapy
A cascade catalytic nanoplatform was established for effective chemodynamic antibacterial therapy.
Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping
A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed in vitro and in vivo, and its biomedical application for sentinel lymph node mapping was successfully demonstrated.
Enhanced transdermal efficiency of curcumin-loaded peptide-modified liposomes for highly effective antipsoriatic therapy
The peptide TD that is conjugated to curcumin-loaded liposomes promotes the transdermal delivery and the intracellular uptake of curcumin, and thus the curcumin-loaded peptide-modified liposomes effectively enhance the inhibition of psoriasis.
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer
Schematic illustration of PtCo NSs for enhanced tumor radiotherapy.
A novel microbial fuel cell electrode design: prototyping a self-standing one-step bacteria-encapsulating bioanode with electrospinning
A microbial fuel cell bioanode encapsulating electroactive bacteria in core–shell fibers mixed with a conductive scaffold was electrospun. This new design opens up perspectives of storable ready-to-use anodes for portable applications.
Regulation of gene transfection by cell size, shape and elongation on micropatterned surfaces
Cell morphology controlled by micropatterns had different influences on gene transfection. Cell size and aspect ratio could increase gene transfection efficiency, while cell shape showed no influence.
About this collection
This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2021 marked as HOT (selected by our Editors as especially significant based on reviewers’ recommendations and their own appraisal). Congratulations to all the authors whose articles are featured!