Issues affecting nanomedicines on the way from the bench to the market
The development of innovative nanomedicine has raised the standards over the last few decades.
Functional peptide-based drug delivery systems
Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.
Bioinspired wettable–nonwettable micropatterns for emerging applications
Wettable–nonwettable micropatterns have received tremendous attention due to their unique functionalities. Their emerging applications have been highlighted in this review.
Phospholipid-mimicking cell-penetrating polymers: principles and applications
Phospholipid-mimicking amphiphilic polymers show nonendocytic internalization by membrane fusion.
Cleaving DNA by nanozymes
Various nanomaterials can mimic the activities of nucleases for hydrolytic and oxidative DNA cleavage on different sites allowing interesting biomedical and bioanalytical applications.
Triggering specific chemical reactions in the disease microenvironment can produce species for disease treatment that have high theranostic performance and low side effects on healthy cells/tissues.
A review of in vitro cell culture testing methods for bioactive glasses and other biomaterials for hard tissue regeneration
Bioactive glasses are used to regenerate bone, and when developing new compositions, in vitro cell culture studies are key. As test parameters vary widely, this review provides an overview, helping researchers to select the appropriate ones.
Nanodiamonds for bioapplications, recent developments
This review describes the very recent bioapplications of nanodiamonds combining nanoparticles and diamond features, underlining their multiple roles in theranostics.
Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases
Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases.
Growing tool-kit of photosensitizers for clinical and non-clinical applications
Photosensitizers are photosensitive molecules utilized in clinical and non-clinical applications by taking advantage of light-mediated reactive oxygen generation, which triggers local and systemic cellular toxicity.
Design of hydrogel-based scaffolds for the treatment of spinal cord injuries
Hydrogel-based scaffold design approaches for the treatment of spinal cord injuries.
Recent advances in pH-responsive nanomaterials for anti-infective therapy
The design and synthesis of pH-responsive antibacterial nanomaterials and their applications in anti-infective therapy.
Supramolecular ensembles modified by near-infrared dyes and their biological applications
This review presents recently developed supramolecular ensembles modified by near-infrared dyes. We discussed the construction of these near-infrared dyes-based ensembles and their biological application.
Bioactive metal-containing nanomaterials for ferroptotic cancer therapy
The metal-containing nanomaterials with inherent physichemical properties are potential agents for ferroptotic cancer therapy.
Advanced biomedical applications based on emerging 3D cell culturing platforms
We discuss the recent progress in the development of scaffold-free techniques for the fabrication of cell spheroids and their biomedical applications.
Cellulose-based dispersants and flocculants
Various cellulosic derivatives ranging from nanoparticles to macromolecular compounds were studied as biodegradable and renewable dispersants and flocculants.
A mini-review of embedded 3D printing: supporting media and strategies
Embedded 3D printing is an additive manufacturing method based on a material extrusion strategy.
Group IV nanodots: synthesis, surface engineering and application in bioimaging and biotherapy
A timeline for C, Si, Ge NDs, showing the development of synthesis, functionalization, bioimaging, and therapy.
Lanthanide nanoparticles with efficient near-infrared-II emission for biological applications
We discuss designing efficient NIR-II-emitting lanthanide NPs and summarize their recent progress in bioimaging, therapy, and biosensing, as well as their limitations and future opportunities.
Nanocomposites for the delivery of bioactive molecules in tissue repair: vital structural features, application mechanisms, updated progress and future perspectives
Nanocomposites have attracted great attention in tissue repair as carriers for bioactive molecule delivery due to their biochemical and nanostructural similarity to that of physiological tissues, and controlled delivery of bioactive molecules.
Mimicking the electrophysiological microenvironment of bone tissue using electroactive materials to promote its regeneration
A timely and comprehensive account of electroactive biomaterials promoting bone regeneration is provided by reviewing their physicochemical and biological properties.
Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review
This review summarizes and discusses recent research progress in chemical and physical chitosan hydrogels for drug delivery.
Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications
With the integrated evaluation of the scaffold profile in the living systems, the decellularized animal, plant, and fungal scaffolds will become essential instruments for safe and controllable biomedical applications.
Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives
Decellularized materials (DMs) are attracting more and more attention in tissue engineering because of their many unique advantages, and they could be further improved in some aspects through various means.
Biomimetic two-dimensional nanozymes: synthesis, hybridization, functional tailoring, and biosensor applications
2D material-based nanozymes exhibited high potential for applications in biosensors and immunoassays.
An insight into cell-laden 3D-printed constructs for bone tissue engineering
In this review, we have spotlighted various combinations of bioinks to optimize the biofabrication of 3D bone constructs.
Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective
A comprehensive review on the biosafety of mesoporous silica nanoparticles for biomedical applications.
From bulk to nano-delivery of essential phytochemicals: recent progress and strategies for antibacterial resistance
Nano-delivery helps to improve the solubility, stability, and efficacy of essential phytochemicals for the inhibition of bacterial resistance.
Natural polysaccharides with different conformations: extraction, structure and anti-tumor activity
Natural polysaccharides as sustainable polymers are rich sources with good biological safety and various biological functions, which are important research topics in the fields of food and medicine.
A minireview of viscosity-sensitive fluorescent probes: design and biological applications
Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules.
Biomass-derived nanocarbon materials for biological applications: challenges and prospects
This review discusses the current status and future potential of biomass-derived nanocarbons for a wide range of biomedical/environmental applications, including bioimaging, microbial inactivation, wound care, and microbial electrochemical systems.
Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli
Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli.
Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections
Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades.
Cationic dynamic covalent polymers for gene transfection
Dynamic covalent polymers have revealed strong potential in gene delivery, thanks to their versatile self-assembly, adaptive and responsive behaviors.
DNAzyme–gold nanoparticle-based probes for biosensing and bioimaging
The design and applications of DNAzyme–gold nanoparticle-based probes in biosensing and bioimaging are summarized here.
Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds
The design of inorganic scaffolds able to instruct the immune system, eliciting adequate feedback by tuning specific material properties, has become an emerging field of research.
Promising nanomaterials in the fight against malaria
Nanomaterials can offer customized tools for prophylactic and therapeutic purposes that bring new solutions in different stages of malaria infection.
Carbon nanotube-based biomaterials for orthopaedic applications
Carbon nanotubes can enhance the functionality of orthopedic applications.
Temperature-responsive supramolecular hydrogels
A subclass of hydrogels which are prepared from supramolecular interactions can realized enhanced functionality, especially in the context of biomedical applications, upon the inclusion of temperature-responsive properties.
Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates
The development and progress of antimicrobial polypeptides and saccharide–polypeptide conjugates in regards to their structural design, biological functions and antimicrobial mechanism.
Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch
Photoisomerization and red-shifted photoswitching make azobenzene superior for exploring the cell-material interactions and designing tissue-engineering scaffolds.
Advances in biomedical and pharmaceutical applications of protein-stabilized gold nanoclusters
The review provides an overview on protein-stabilized gold nanoclusters which offer intriguing applications for the use as theranostics, as diagnostics and as biosensors.
Stimuli-responsive functional materials for soft robotics
This review provides an overview of stimuli-responsive functional materials and their applications in soft robotics.
Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application
Nitrogen-doped carbon dots have emerged as a biocompatible functional carbon nanomaterial for a variety of biomedical applications such as optical imaging, photoacoustic imaging, drug delivery, photothermal therapy, and photodynamic therapy.
Core–shell nanostructures: perspectives towards drug delivery applications
Nanosystems have shown encouraging outcomes and substantial progress in the areas of drug delivery and biomedical applications.
Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer
Oral cancer is a common malignant life-threatening tumor.
Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases
Nanomaterials with excellent ROS-scavenging ability and biodistribution are considered as promising candidates in alleviating oxidative stress and restoring redox balance in CNS diseases, further facilitating the function recovery of the CNS.
In situ formation of injectable hydrogels for chronic wound healing
Hydrogels have been widely used in wound healing treatment over the past decade.
Harnessing biomolecules for bioinspired dental biomaterials
We review the range of biomolecules used across dental biomaterials to spur the design and implementation of bioinspired multifunctional materials.
Liquid-phase electron microscopy imaging of cellular and biomolecular systems
Liquid-phase electron microscopy, a new method for real-time nanoscopic imaging in liquid, makes it possible to study cells or biomolecules with a singular combination of spatial and temporal resolution. We review the state of the art in biological research in this growing and promising field.
Advances in local and systemic drug delivery systems for post-surgical cancer treatment
Graphical representation of local and systemic drug delivery systems.
Functionalized graphene oxide as a vehicle for targeted drug delivery and bioimaging applications
Graphene oxide (GO) has emerged as a polynomially functional carbon nanomaterial with rational applications in diverse fields such as biomedical engineering, electrocatalysis, biosensing, energy conversion, and storage devices.
Multicomponent polysaccharide alginate-based bioinks
3D-Bioprinting has seen a rapid expansion in the last few years, with an increasing number of reported bioinks, amongst which, alginate is an ideal ingredient due to its biocompatibility and ease of gelation.
Advancements in the development on new liquid embolic agents for use in therapeutic embolisation
This review covers the current state-of-the-art in the development of liquid embolics for therapeutic embolisation.
Recent advances in supramolecular block copolymers for biomedical applications
Supramolecular block copolymers with a dynamically reversible nature and hierarchical microphase-separated structures can greatly enrich the library of pharmaceutical carriers and outline future research directions for biological applications.
Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy
The recent advances of polyoxometalate clusters in terms of near infrared photothermal properties for targeted tumor therapy have been summarized while the combined applications with various bio-imaging techniques and chemotherapies are reviewed.
Gradient scaffolds for osteochondral tissue engineering and regeneration
The tissue engineering approach for repairing osteochondral (OC) defects involves the fabrication of a biological tissue scaffold that mimics the physiological properties of natural OC tissue (e.g., the gradient transition between the cartilage surface and the subchondral bone).
Recent advances of near infrared inorganic fluorescent probes for biomedical applications
Near infrared (NIR)-excitable and NIR-emitting probes have fuelled advances in biomedical applications owing to their power in enabling deep tissue imaging, offering high image contrast and reducing phototoxicity.
Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels
This review highlights recent advances in bio-orthogonal and dynamic hydrogels crosslinked by irreversible click chemistry, enzymatic reactions, and covalent-adaptable network.
Detection signal amplification strategies at nanomaterial-based photoelectrochemical biosensors
This review focusses on unique material modification and signal amplification strategies reported in developing photoelectrochemical biosensors with utmost sensitivity and selectivity.
Vertical nanowire array-based biosensors: device design strategies and biomedical applications
We review the recent progress of vertical nanowire (VNW) array-based biosensors for the effective collection of biomedical information at the molecular level, extracellular level, and intracellular level.
Three-dimensional scaffold-free microtissues engineered for cardiac repair
In this review article, we present the state-of-the-art approaches and recent advancements in the engineering of scaffold-free cardiac microtissues for myocardial repair.
Exosome: a significant nano-scale drug delivery carrier
Exosomes have outstanding advantages as drug delivery carriers in the treatment of various diseases.
Enzyme catalysis powered micro/nanomotors for biomedical applications
This review provides insights on enzyme powered motors using fuels present in biological environments for biomedical applications.
Flexible electrochemical biosensors for healthcare monitoring
Flexible electrochemical biosensors are studied hugely because of tremendous advantages including the fast response, high sensitivity, inherent miniaturization, convenient operation, and portability which are suitable for wearable biosensors.
Nanoclay-based drug delivery systems and their therapeutic potentials
Natural and modified nanostructured clay minerals as drug carriers and support matrices for drug delivery, cancer therapy, gene therapy, and tissue engineering.
Stimuli-responsive polymer-based systems for diagnostic applications
The unique properties of stimuli-responsive polymers make them valuable for myriad applications, their use for biosensing and molecular diagnostics is reviewed here.
Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies
Wound healing microphysiological systems have been engineered with synthetic and natural materials and techniques such as bioprinting or viscous finger patterning. Model designs focus on particular phases of wound healing or the recapitulation of micro-anatomies.
Finely tuned Prussian blue-based nanoparticles and their application in disease treatment
The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours.
Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine
Owing to fascinating properties and biodegradability, opportunities and challenges of emerging black phosphorus (BP) and BP analogs (BPAs) in biomedical applications have been coexisted to study.
About this collection
This collection contains recent Review-type articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this collection as soon as possible after publication.