Current advances in nano-delivery of celastrol for treating inflammation-associated diseases
Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases. Celastrol, a compound isolated from a Chinese medicinal herb, holds great potential in treating multiple inflammation-associated diseases. However, its further clinical use is limited by poor solubility, bioavailability, and high organ toxicity. With the advancement of nanotechnology, nano-delivery of celastrol can effectively improve its oral bioavailability, maximize its efficacy and minimize its side effects. Here, we summarize the roles of celastrol in the treatment of various inflammation-associated diseases, with special emphasis on its role in modulating immune cells signaling or non-immune cells signaling within the inflammatory microenvironment, and highlights the latest advances in nano-delivery strategies for celastrol to treat diseases associated with inflammation.
- This article is part of the themed collection: Journal of Materials Chemistry B Recent Review Articles