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Current advances in nano-delivery of celastrol for treating inflammation-associated diseases

Abstract

Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases. Celastrol, a compound isolated from a Chinese medicinal herb, holds great potential in treating multiple inflammation-associated diseases. However, its further clinical use is limited by poor solubility, bioavailability, and high organ toxicity. With the advancement of nanotechnology, nano-delivery of celastrol can effectively improve its oral bioavailability, maximize its efficacy and minimize its side effects. Here, we summarize the roles of celastrol in the treatment of various inflammation-associated diseases, with special emphasis on its role in modulating immune cells signaling or non-immune cells signaling within the inflammatory microenvironment, and highlights the latest advances in nano-delivery strategies for celastrol to treat diseases associated with inflammation.

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Article information


Submitted
11 Aug 2020
Accepted
13 Oct 2020
First published
15 Oct 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

Current advances in nano-delivery of celastrol for treating inflammation-associated diseases

G. Fang and B. Tang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB01939A

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