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Themed collection International Year of the Periodic Table: Precious metals for cancer treatment

48 items
Review Article

Current status and future perspectives of gold nanoparticle vectors for siRNA delivery

Discovering the vast therapeutic potential of siRNA opened up new clinical research areas focussing on a number of diseases and applications; however significant problems with siRNA stability and delivery have hindered its clinical applicability.

Graphical abstract: Current status and future perspectives of gold nanoparticle vectors for siRNA delivery
Communication

Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics

The nanoparticles exhibit excellent tumor accumulation and lead to complete tumor eradication with low power NIR laser irradiation.

Graphical abstract: Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics
From the themed collection: National Nanotechnology Day
Communication

A multifunctional mesoporous silica–gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay

Breast cancer detection: The biosensor based on HER2 antibodies attached to MSN–AuNC hybrids is sensitive, selective, economical and simple to operate.

Graphical abstract: A multifunctional mesoporous silica–gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay
Communication

Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Inspired by the chain reactions among silver nanoparticles, glucose oxidase (GOx) and intratumoral glucose, a degradable silver-based nanoplatform was developed for synergistic cancer starving-like/metal ion therapy.

Graphical abstract: Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy
Open Access Communication

Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications

MCF7 Cells biomineralize gold ions into long aspect-ratio nanoribbons in the presence of spherical nanoparticles as seeds with excellent photothermal properties.

Graphical abstract: Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications
From the themed collection: Recent Open Access Articles
Communication

Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Hyaluronic acid nanoparticles containing a platinum(II)–silicon(IV) phthalocyanine conjugate exhibited selective uptake by cancer cells and potent mitochondria-targeted PDT and chemotherapy.

Graphical abstract: Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light
Communication

Tumor-adapting and tumor-remodeling AuNR@dendrimer-assembly nanohybrids overcome impermeable multidrug-resistant cancer

Herein, smart Au nanorod@dendrimer-assembly nanohybrids (AuNR@DA NHs) were developed for adapting sequential biological barriers and remodeling tumor permeability, thereby achieving multimodal enhancement of penetration and internalization in multidrug-resistant poorly-permeable tumors.

Graphical abstract: Tumor-adapting and tumor-remodeling AuNR@dendrimer-assembly nanohybrids overcome impermeable multidrug-resistant cancer
Communication

Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification

Herein, we demonstrate a novel, facile, and suitable strategy for imaging GSH based on mercaptopyrimidine-directed gold nanoclusters (Au NCs).

Graphical abstract: Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification
Communication

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Smart gold nanoparticle-stabilized ultrasound microbubbles (SAuMBs) having diagnostic (US and PAT) and therapeutic (PTT) effects were applied as cancer theranostics.

Graphical abstract: Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics
Communication

Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging

Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization.

Graphical abstract: Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging
Open Access Paper

Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods

Morphological changes and trypan-blue staining are temporally tracked in single cells via optical microscopy after plasmonic photothermal heating.

Graphical abstract: Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods
From the themed collection: Recent Open Access Articles
Open Access Paper

Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor

The key role of polyethylene glycol is demonstrated.

Graphical abstract: Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor
Open Access Paper

Optimising gold nanorods for photoacoustic imaging in vitro

A study to find the optimum sized gold nanorod for use in PA imaging and/or optical-based theranostics, by comparing four different sizes with similar aspect ratios.

Graphical abstract: Optimising gold nanorods for photoacoustic imaging in vitro
Paper

A copper-mediated on–off–on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition

The AuNCs@Tf-Cu2+ system for the sensitive and selective detection of endogenous glutathione (GSH) can illuminate tumor cells rather than normal cells, which implied its great potential application in cancer diagnosis.

Graphical abstract: A copper-mediated on–off–on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition
Paper

Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows

Gold nanostars were developed for cancer cell-targeted NIR-I/II SERS-imaging and PPTT.

Graphical abstract: Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows
Paper

Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(IV) prodrug for enhanced anticancer therapy

A multifunctional nanoplatform exhibits selective intracellular co-delivery of Pt(II) and NO under 808 nm light irradiation, accompanied by photothermal therapy.

Graphical abstract: Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy
Paper

AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo

Recent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (TP-PDT).

Graphical abstract: AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo
Paper

Polyethyleneimine-assisted one-pot synthesis of quasi-fractal plasmonic gold nanocomposites as a photothermal theranostic agent

Polyethyleneimine-assisted one-pot synthesis of gold nanoparticles that self-arrange into fractal nanoaggregates and demonstrate photo-thermal therapeutic and imaging efficiency.

Graphical abstract: Polyethyleneimine-assisted one-pot synthesis of quasi-fractal plasmonic gold nanocomposites as a photothermal theranostic agent
Paper

Titania-coated 2D gold nanoplates as nanoagents for synergistic photothermal/sonodynamic therapy in the second near-infrared window

Au NPL@TiO2 nanostructures play the dual role of heat- and ROS-generating agents, which lead to synergetic photothermal/sonodynamic therapy in the second biological window.

Graphical abstract: Titania-coated 2D gold nanoplates as nanoagents for synergistic photothermal/sonodynamic therapy in the second near-infrared window
Paper

Flower-like gold nanoparticles for enhanced photothermal anticancer therapy by the delivery of pooled siRNA to inhibit heat shock stress response

Surface modified gold nanoflowers were employed as synergistic therapeutics for photothermal ablation and gene silencing.

Graphical abstract: Flower-like gold nanoparticles for enhanced photothermal anticancer therapy by the delivery of pooled siRNA to inhibit heat shock stress response
Paper

Dual-template cascade synthesis of highly multi-branched Au nanoshells with ultrastrong NIR absorption and efficient photothermal therapeutic intervention

A universal dual-template cascade strategy for the synthesis of multi-branched gold nanoshells with ultrastrong NIR absorption for tumor photothermal therapy.

Graphical abstract: Dual-template cascade synthesis of highly multi-branched Au nanoshells with ultrastrong NIR absorption and efficient photothermal therapeutic intervention
Paper

Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light

We coupled the photothermal and thermoresponsive properties in one nanoplatform by wrapping AuNRs@mSiO2 with thermoresponsive lipid bilayer.

Graphical abstract: Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light
Paper

Fluorescence turn-off Ag/fluorinated graphene composites with high NIR absorption for effective killing of cancer cells and bacteria

This study establishes FGO–Ag as a novel fluorescence “turn-off” nanocarrier with good targeting efficiency and high NIR absorption and drug loading; it also demonstrates its application in antibacterial and cancer chemo-photothermal treatments.

Graphical abstract: Fluorescence turn-off Ag/fluorinated graphene composites with high NIR absorption for effective killing of cancer cells and bacteria
Paper

BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy

BSA-bioinspired, immunoadjuvant-loaded gold nanorods for synergetic cancer photothermal therapy and immunotherapy.

Graphical abstract: BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy
Open Access Paper

Specific binding and internalization: an investigation of fluorescent aptamer-gold nanoclusters and cells with fluorescence lifetime imaging microscopy

A fluorescence lifetime imaging microscopy technique is used to discriminate between the specific binding of biofunctionalized fluorescent gold nanoclusters on cells and their subsequent internalization.

Graphical abstract: Specific binding and internalization: an investigation of fluorescent aptamer-gold nanoclusters and cells with fluorescence lifetime imaging microscopy
From the themed collection: Recent Open Access Articles
Paper

Carboplatin-loaded SMNDs to reduce GSH-mediated platinum resistance for prostate cancer therapy

Glutathione (GSH)-mediated drug resistance can strongly weaken the therapeutic efficiency of platinum(II).

Graphical abstract: Carboplatin-loaded SMNDs to reduce GSH-mediated platinum resistance for prostate cancer therapy
Paper

Precise synchronization of hyperthermia–chemotherapy: photothermally induced on-demand release from injectable hydrogels of gold nanocages

Temperature sensitive polymers were modified onto gold nanocages, and the resultant temperature sensitive hydrogels achieved precise synchronization of hyperthermia and chemotherapy by the on-demand release.

Graphical abstract: Precise synchronization of hyperthermia–chemotherapy: photothermally induced on-demand release from injectable hydrogels of gold nanocages
Paper

Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models

We report the in vivo biodistribution of luminescent gold nanoclusters (NCs) stabilized by bidentate zwitterionic molecules in subcutaneous and orthotopic glioblastoma mice models.

Graphical abstract: Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models
Paper

Transient DNA damage following exposure to gold nanoparticles

DNA damage induced by gold nanoparticles is largely repaired over time, indicating that DNA damage is of transient nature.

Graphical abstract: Transient DNA damage following exposure to gold nanoparticles
Paper

Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo

Tunable aggregation of gold-silica janus nanoparticles is utilized to enable contrast-enhanced multiwavelength photoacoustic imaging in vitro/in vivo.

Graphical abstract: Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo
Paper

Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window

Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to the high light penetration depth and minimal optical scattering in the NIR II region (1000–1350 nm).

Graphical abstract: Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window
Paper

Graphene oxide coating core–shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors

FA-modified-GO coated core–shell Ag2S@mesoporous silica where DOX was loaded for active targeting FL/PA imaging and synergistic chemo-photothermal therapy of tumors.

Graphical abstract: Graphene oxide coating core–shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors
Paper

Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells

A localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers, offers the potential for a LED-induced mild photothermal effect which enhances gene silencing effect in cancer cells.

Graphical abstract: Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells
Paper

The influence of polyethylene glycol passivation on the surface plasmon resonance induced photothermal properties of gold nanorods

This comprehensive study suggested an optimum PEG polymer length of 5 kDa is advantageous for surface passivation and colloidal stability of AuNRs, which also maximizes the heat conduction from the nanorod–liquid interface to the surroundings, thereby, enhancing photothermal efficiency.

Graphical abstract: The influence of polyethylene glycol passivation on the surface plasmon resonance induced photothermal properties of gold nanorods
Paper

Highly sensitive fluorescence quantification of intracellular telomerase activity by repeat G-rich DNA enhanced silver nanoclusters

As an important biomarker for early cancer diagnosis and a valuable therapeutic target, the detection and monitoring of telomerase activity has attracted extensive attention.

Graphical abstract: Highly sensitive fluorescence quantification of intracellular telomerase activity by repeat G-rich DNA enhanced silver nanoclusters
Paper

A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy

Novel contrast agent were designed for in vivo T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy-mediated chemosensitization for cancer therapy.

Graphical abstract: A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy
Paper

A gold nanoflower-based traceable drug delivery system for intracellular SERS imaging-guided targeted chemo-phototherapy

A novel traceable and targeted drug delivery nanosystem with high drug encapsulation and pH-controlled release was prepared based on gold nanoflowers for efficient intracellular SERS imaging-guided chemo-phototherapy.

Graphical abstract: A gold nanoflower-based traceable drug delivery system for intracellular SERS imaging-guided targeted chemo-phototherapy
Paper

The comparative effect of wrapping solid gold nanoparticles and hollow gold nanoparticles with doxorubicin-loaded thermosensitive liposomes for cancer thermo-chemotherapy

Since conventional chemotherapy is a systemic treatment that affects the body globally and will not concentrate inside the tumor, it causes adverse side effects to patients.

Graphical abstract: The comparative effect of wrapping solid gold nanoparticles and hollow gold nanoparticles with doxorubicin-loaded thermosensitive liposomes for cancer thermo-chemotherapy
Paper

In vivo tumor active cancer targeting and CT-fluorescence dual-modal imaging with nanoprobe based on gold nanorods and InP/ZnS quantum dots

Gold nanorod, InP/ZnS QD and c(RGDfC) based multifunctional nanoprobe for dual-modal imaging of active targeting of tumors in vivo.

Graphical abstract: In vivo tumor active cancer targeting and CT-fluorescence dual-modal imaging with nanoprobe based on gold nanorods and InP/ZnS quantum dots
Paper

A degradable hydrogel formed by dendrimer-encapsulated platinum nanoparticles and oxidized dextran for repeated photothermal cancer therapy

A Dex-DEPt hydrogel was immobilized in tumors for a period of days to allow repeated PTT and degraded spontaneously post-treatment.

Graphical abstract: A degradable hydrogel formed by dendrimer-encapsulated platinum nanoparticles and oxidized dextran for repeated photothermal cancer therapy
Paper

Triple therapy of hepatocellular carcinoma with microRNA-122 and doxorubicin co-loaded functionalized gold nanocages

A combination of different therapy strategies has great potential to efficaciously treat malignant tumors, by virtue of their synergetic effects.

Graphical abstract: Triple therapy of hepatocellular carcinoma with microRNA-122 and doxorubicin co-loaded functionalized gold nanocages
Paper

Crystalline assembly of gold nanoclusters for mitochondria targeted cancer theranostics

Herein, we report the formation of a crystalline assembly of gold (Au) nanoclusters for cancer theranostics via active targeting of mitochondria.

Graphical abstract: Crystalline assembly of gold nanoclusters for mitochondria targeted cancer theranostics
Paper

Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities

Gold nanoparticles with various positive charge densities and hydrophobicities induce cellular oxidative stress differently and sensitize cancer cells to paclitaxel.

Graphical abstract: Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities
Paper

A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

A versatile GNS-NLS@HA nanoplatform was constructed for tumor cellular/intranuclear dual-targeting photothermal therapy. It displayed excellent tumor inhibition efficiency as well as anti-metastasis ability in vivo.

Graphical abstract: A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy
Paper

Optimum morphology of gold nanorods for light-induced hyperthermia

A systematic study of the influence of gold nanorod morphology on cellular toxicity, uptake and light to heat conversion.

Graphical abstract: Optimum morphology of gold nanorods for light-induced hyperthermia
Paper

Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells

Gold nanourchins (AuNUs) associate with lysosomes and lipid droplets (LDs) in glioblastoma cells. AuNUs reorganize F-actin, microtubules and the nuclear lamina. This alters cell signaling and increases cell death. Cell injury is further enhanced by celastrol.

Graphical abstract: Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells
Paper

Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy

A vibrating nozzle system to produce Au-GO@ZC-DOX nanovesicles possessed enhanced treatment effects for pancreatic cancers.

Graphical abstract: Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy
Paper

One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor

One-step coelectrodeposition-assisted layer-by-layer assembly was employed for preparing multilayer thin films with a controlled three-dimensional nanoarchitecture and application in an ultrasensitive DNA biosensor.

Graphical abstract: One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor
48 items

About this collection

Guest Edited by Zhiqun Lin, Journal of Materials Chemistry A Associate Editor, Georgia Institute of Technology, USA and Xiaogang Qu, Journal of Materials Chemistry B Associate Editor, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China

This themed collection is the fourth in a series celebrating the International Year of the Periodic Table. For decades, nanoscale precious metals have been widely applied in biomedical research due to their specific plasmonic and catalytic properties. This themed issue showcases works on recent development of nanostructured precious metal for sensing, diagnosis, and synergistic cancer treatment. The papers selected in this issue focus on unique structural design of Au, Ag and Pt nanocrystals for applications from bioimaging, controlled delivery to photothermal therapy.

‘Precious metals for cancer treatment’ features papers from across the Materials and Nano journal porfolio, including Nanoscale Horizons, Journal of Materials Chemistry B, Nanoscale, and Nanoscale Advances.

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