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Issue 6, 2019
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Current status and future perspectives of gold nanoparticle vectors for siRNA delivery

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Abstract

Discovering the vast therapeutic potential of siRNA opened up new clinical research areas focussing on a number of diseases and applications; however significant problems with siRNA stability and delivery have hindered its clinical applicability. As a result, interest in the development of practical siRNA delivery systems has grown in recent years. Of the numerous siRNA delivery strategies currently on offer, gold nanoparticles (AuNPs) stand out thanks to their biocompatibility and capacity to protect siRNA against degradation; not to mention the versatility offered by their tuneable shape, size and optical properties. Herein this review provides a complete summary of the methodologies for functionalizing AuNPs with siRNA, paying singular attention to the AuNP shape, size and surface coating, since these key factors heavily influence cellular interaction, internalization and, ultimately, the efficacy of the hybrid particle. The most noteworthy hybridization strategies have been highlighted along with the most innovative and outstanding in vivo studies with a view to increasing clinical interest in the use of AuNPs as siRNA nanocarriers.

Graphical abstract: Current status and future perspectives of gold nanoparticle vectors for siRNA delivery

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Publication details

The article was received on 20 Sep 2018, accepted on 09 Jan 2019 and first published on 11 Jan 2019


Article type: Review Article
DOI: 10.1039/C8TB02484G
Citation: J. Mater. Chem. B, 2019,7, 876-896

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    Current status and future perspectives of gold nanoparticle vectors for siRNA delivery

    Á. Artiga, I. Serrano-Sevilla, L. De Matteis, S. G. Mitchell and J. M. de la Fuente, J. Mater. Chem. B, 2019, 7, 876
    DOI: 10.1039/C8TB02484G

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