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Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics

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Abstract

A Pt prodrug polyphenol and gadolinium ion loaded cancer theranostics nanoplatform based on a mild acidic pH and thermal sensitive polymer was designed for photoacoustic (PA)/magnetic resonance (MR)/positron emission tomography (PET) multimodal imaging-guided chemo-photothermal combination therapy. The Pt drug release can be controlled by tumour-specific acidic pH and heat generated by external NIR irradiation. The nanoparticles were stable under normal physiological environments and released the drug under the acidic pH of tumours and NIR laser irradiation, which can reduce the side effects of the drug to normal organs. Moreover, the MR signal can be significantly enhanced (∼3-fold increase in T1 relaxivity) under the acidic tumour microenvironment, which is favorable for cancer diagnosis. The nanoparticles exhibited excellent tumour accumulation and led to complete tumour eradication with low power NIR laser irradiation. This promising approach provides a new avenue for imaging-guided combination therapy.

Graphical abstract: Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics

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Publication details

The article was received on 14 Sep 2018, accepted on 18 Oct 2018 and first published on 18 Oct 2018


Article type: Communication
DOI: 10.1039/C8NH00307F
Citation: Nanoscale Horiz., 2019, Advance Article
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    Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics

    Z. Yang, Y. Dai, L. Shan, Z. Shen, Z. Wang, B. C. Yung, O. Jacobson, Y. Liu, W. Tang, S. Wang, L. Lin, G. Niu, P. Huang and X. Chen, Nanoscale Horiz., 2019, Advance Article , DOI: 10.1039/C8NH00307F

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