Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
We review pharmacological chaperones used in lysosomal storage diseases, emphasizing medicinal chemistry approaches and mechanisms of action.
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
Using machine learning, targets were identified for β-lapachone.
Modified nucleoside triphosphates exist in mammals
By establishing a chemical labeling method in combination with liquid chromatography-mass spectrometry analysis, we reported the widespread existence of various modified nucleoside triphosphates in eukaryotes.
A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage
A convenient method to bi-terminally modify proteins using recombinant masking groups reveals that H2A.X ubiquitylation opens chromatin during DNA repair.
A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy
We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer.
Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process
Two AIEgens are designed for tracking mitochondria and lysosomes with different emission colors using single wavelength excitation to visualize the mitophagy process.
Discrete Cu(I) complexes for azide–alkyne annulations of small molecules inside mammalian cells
Cu(I) complexes do achieve azide–alkyne annulations of freely difusible small molecules inside mammalian cells.
Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides
Arylboronic acid-modified antisense oligonucleotides enable hydrogen peroxide induced gene silencing in mammalian cells.
Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection
A PNA-templated peptide ligation reaction has been developed between selenocystine and selenoesters. The methodology was used for the sequence specific detection of miRNA at low concentrations.
Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box
Newly described NMR experimental approaches can provide valuable structural details and a complementary means of structure verification.
Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker
Peptides with various C-terminal functionalization, including peptides and dendrimers, were prepared via SPPS and an efficient on-resin modification.
About this collection
We are delighted to present this web collection of most impactful Chemical Science articles within the area of Chemical Biology. Including one review article and 10 research articles, this collection presents some outstanding contributions to the field, ranging from the addition of new tools to the structure elucidation toolbox to machine learning approaches to identify targets for β-lapachone. We hope you enjoy browsing through this collection.