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Themed collection Most impactful Chemical Biology articles of 2018

11 items
Open Access Perspective

Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

We review pharmacological chaperones used in lysosomal storage diseases, emphasizing medicinal chemistry approaches and mechanisms of action.

Graphical abstract: Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
Open Access Edge Article

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Using machine learning, targets were identified for β-lapachone.

Graphical abstract: Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
From the themed collection: The ChemRxiv Collection
Open Access Edge Article

Modified nucleoside triphosphates exist in mammals

By establishing a chemical labeling method in combination with liquid chromatography-mass spectrometry analysis, we reported the widespread existence of various modified nucleoside triphosphates in eukaryotes.

Graphical abstract: Modified nucleoside triphosphates exist in mammals
Open Access Edge Article

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

A convenient method to bi-terminally modify proteins using recombinant masking groups reveals that H2A.X ubiquitylation opens chromatin during DNA repair.

Graphical abstract: A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage
Open Access Edge Article

A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer.

Graphical abstract: A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy
Open Access Edge Article

Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process

Two AIEgens are designed for tracking mitochondria and lysosomes with different emission colors using single wavelength excitation to visualize the mitophagy process.

Graphical abstract: Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process
Open Access Edge Article

Discrete Cu(I) complexes for azide–alkyne annulations of small molecules inside mammalian cells

Cu(I) complexes do achieve azide–alkyne annulations of freely difusible small molecules inside mammalian cells.

Graphical abstract: Discrete Cu(i) complexes for azide–alkyne annulations of small molecules inside mammalian cells
Open Access Edge Article

Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides

Arylboronic acid-modified antisense oligonucleotides enable hydrogen peroxide induced gene silencing in mammalian cells.

Graphical abstract: Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides
Open Access Edge Article

Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection

A PNA-templated peptide ligation reaction has been developed between selenocystine and selenoesters. The methodology was used for the sequence specific detection of miRNA at low concentrations.

Graphical abstract: Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection
Open Access Edge Article

Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box

Newly described NMR experimental approaches can provide valuable structural details and a complementary means of structure verification.

Graphical abstract: Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box
Open Access Edge Article

Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker

Peptides with various C-terminal functionalization, including peptides and dendrimers, were prepared via SPPS and an efficient on-resin modification.

Graphical abstract: Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker
11 items

About this collection

We are delighted to present this web collection of most impactful Chemical Science articles within the area of Chemical Biology. Including one review article and 10 research articles, this collection presents some outstanding contributions to the field, ranging from the addition of new tools to the structure elucidation toolbox to machine learning approaches to identify targets for β-lapachone. We hope you enjoy browsing through this collection.

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