Themed collection Asymmetric catalysis

23 items
Open Access Minireview

Asymmetric one-pot reactions using heterogeneous chemical catalysis: recent steps towards sustainable processes

Asymmetric one-pot reactions applying heterogeneous chemical catalysts and unifying the benefits of these catalytic materials with the advantages of one-pot methods, are surveyed.

Graphical abstract: Asymmetric one-pot reactions using heterogeneous chemical catalysis: recent steps towards sustainable processes
From the themed collection: Asymmetric catalysis
Open Access Review Article

The role of biocatalysis in the asymmetric synthesis of alkaloids – an update

This review article discusses developments in the chemo-enzymatic synthesis of alkaloids since 2013, showcasing how modern methods of organic synthesis and biocatalysis are combined to establish novel routes towards these important natural products.

Graphical abstract: The role of biocatalysis in the asymmetric synthesis of alkaloids – an update
From the themed collection: 2021 Reviews in RSC Advances
Open Access Review Article

Asymmetric catalysis in direct nitromethane-free Henry reactions

This review summarizes the current state and applications of catalytic Henry reactions involving complex nitroalkanes coupling with various carbonyl compounds to generate chiral β-nitro alcohol scaffolds with four adjacent stereogenic centers.

Graphical abstract: Asymmetric catalysis in direct nitromethane-free Henry reactions
From the themed collection: Asymmetric catalysis
Open Access Review Article

Application of asymmetric Sharpless aminohydroxylation in total synthesis of natural products and some synthetic complex bio-active molecules

This work shows applications of Asymmetric Sharpless Aminohydroxylation (ASAH) in the stereoselective synthesis of vicinal amino alcohols as important intermediates in the total synthesis of complex molecules and natural products with significant biological activities.

Graphical abstract: Application of asymmetric Sharpless aminohydroxylation in total synthesis of natural products and some synthetic complex bio-active molecules
From the themed collection: Asymmetric catalysis
Review Article

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

3-Substituted-3-aminooxindole motifs constitute the core structure of a number of natural products and drug candidates.

Graphical abstract: Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation
From the themed collection: Asymmetric catalysis
Review Article

Recent development of direct asymmetric functionalization of inert C–H bonds

This review summarized recent development (contributions after 2009) in the area of direct catalytic asymmetric functionalization reactions of inert C–H bonds.

Graphical abstract: Recent development of direct asymmetric functionalization of inert C–H bonds
From the themed collection: Asymmetric catalysis
Review Article

Catalytic asymmetric synthesis of 3-hydroxyoxindole: a potentially bioactive molecule

The recent emergence of biological activities of chiral 3-substituted-3-hydroxy-2-oxindoles has inspired synthetic chemists to develop new methodologies for their synthesis.

Graphical abstract: Catalytic asymmetric synthesis of 3-hydroxyoxindole: a potentially bioactive molecule
From the themed collection: Asymmetric catalysis
Communication

Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

Asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols via a cascade biocatalysis system.

Graphical abstract: Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system
From the themed collection: Asymmetric catalysis
Open Access Paper

Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Simple primary β-amino alcohols X act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters A with nitroalkenes B affording highly pure chiral Michael adducts C.

Graphical abstract: Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes
From the themed collection: Asymmetric catalysis
Open Access Paper

Enantioselective organocatalytic Michael reactions using chiral (R,R)-1,2-diphenylethylenediamine-derived thioureas

Although the Michael addition is a very well-known and widely applied reaction, cost-effective, metal-free, and readily prepared organic catalysts remain rare.

Graphical abstract: Enantioselective organocatalytic Michael reactions using chiral (R,R)-1,2-diphenylethylenediamine-derived thioureas
From the themed collection: Asymmetric catalysis
Paper

Insights into isothiourea-catalyzed asymmetric [3 + 3] annulation of α,β-unsaturated aryl esters with 2-acylbenzazoles: mechanism, origin of stereoselectivity and switchable chemoselectivity

The switchable chemoselectivity of isothiourea-catalyzed asymmetric [3 + 3] annulation of α,β-unsaturated aryl esters with 2-acylbenzazoles has been predicted successfully.

Graphical abstract: Insights into isothiourea-catalyzed asymmetric [3 + 3] annulation of α,β-unsaturated aryl esters with 2-acylbenzazoles: mechanism, origin of stereoselectivity and switchable chemoselectivity
From the themed collection: Asymmetric catalysis
Open Access Paper

Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

A simple two catalysts component system of β-amino alcohols (catalyst) and amino acids (co-catalyst) works as an efficient organocatalysts in hetero Diels–Alder reaction of isatins with enones to afford chiral spirooxindole-tetrahydropyranones.

Graphical abstract: Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
From the themed collection: Asymmetric catalysis
Paper

Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines

Structurally diverse chiral amines and amino alcohols were synthesized using an engineered thermostable amine dehydrogenase, demonstrating its extensive synthesis potential.

Graphical abstract: Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines
From the themed collection: Asymmetric catalysis
Paper

Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element

Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element.

Graphical abstract: Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element
From the themed collection: Asymmetric catalysis
Paper

Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system

Based on substrate-coupled cofactor regeneration system, a high 2-propanol tolerance SmADH2 together with TBCR system can synthesise structurally diverse chiral alcohols at a high substrate loading with only 1.25 equivalents of 2-propanol.

Graphical abstract: Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system
From the themed collection: Asymmetric catalysis
Open Access Paper

Organocatalytic enantioselective conjugate addition of 2-naphthols to ortho-hydroxyphenyl substituted para-quinone methides: access to unsymmetrical triarylmethanes

The enantioselective conjugate addition of 2-naphthols to ortho-hydroxyphenyl substituted para-quinone methides has been achieved with the aid of a chiral phosphoric acid.

Graphical abstract: Organocatalytic enantioselective conjugate addition of 2-naphthols to ortho-hydroxyphenyl substituted para-quinone methides: access to unsymmetrical triarylmethanes
From the themed collection: Asymmetric catalysis
Paper

An effective strategy for creating asymmetric MOFs for chirality induction: a chiral Zr-based MOF for enantioselective epoxidation

A simple and rapid procedure was used to prepare chiral NU-1000 as a robust Zr-based MOF without complexity. The functionalization of NU-1000 was performed by utilizing chiral L-(+)-tartaric acid via solvent-assisted linker incorporation, resulting in [C-NU-1000]. A Mo-complex was immobilized onto chiral NU-1000 for enantioselective epoxidation.

Graphical abstract: An effective strategy for creating asymmetric MOFs for chirality induction: a chiral Zr-based MOF for enantioselective epoxidation
From the themed collection: Asymmetric catalysis
Open Access Paper

Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans

The first example for direct synthesis of chiral terminal alkynyl isochromans.

Graphical abstract: Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans
From the themed collection: Asymmetric catalysis
Open Access Paper

Hydroxynitrile lyases covalently immobilized in continuous flow microreactors

Enzymes are supreme catalysts when it comes to high enantiopurities and their immobilization will pave the way for continuous operation.

Graphical abstract: Hydroxynitrile lyases covalently immobilized in continuous flow microreactors
From the themed collection: Asymmetric catalysis
Paper

Probing enantioselectivity in rhodium-catalyzed Si–C bond cleavage to construct silicon-stereocenters: a theoretical study

Density functional theory (DFT) calculations indicate that favorable oxidative addition/reductive elimination process from arylrhodium complex determines the enantioselectivity.

Graphical abstract: Probing enantioselectivity in rhodium-catalyzed Si–C bond cleavage to construct silicon-stereocenters: a theoretical study
From the themed collection: Asymmetric catalysis
Paper

Prediction on the origin of selectivities of NHC-catalyzed asymmetric dearomatization (CADA) reactions

The mechanism and origin of selectivities of NHC-catalyzed dearomatization reaction have been theoretically studied.

Graphical abstract: Prediction on the origin of selectivities of NHC-catalyzed asymmetric dearomatization (CADA) reactions
From the themed collection: Asymmetric catalysis
Open Access Paper

Highly stereoselective spirocyclopropanation of various diazooxindoles with olefins catalyzed using Ru(II)-complex

Optically active spirocyclopropyloxindole derivatives were efficiently synthesized from diazooxindoles and olefins in the presence of a Ru(II)-Pheox catalyst.

Graphical abstract: Highly stereoselective spirocyclopropanation of various diazooxindoles with olefins catalyzed using Ru(ii)-complex
From the themed collection: Asymmetric catalysis
Open Access Paper

Asymmetric synthesis of chromene skeletons via organocatalytic domino reactions of in situ generated ortho-quinone methide with malononitrile and β-functionalized ketone

Enantioselective organocatalytic domino reactions of in situ generated ortho-quinone methides with malononitrile and β-functionalized ketones have been developed. This strategy could generate various chiral chromenes in high yields and stereoselectivities.

Graphical abstract: Asymmetric synthesis of chromene skeletons via organocatalytic domino reactions of in situ generated ortho-quinone methide with malononitrile and β-functionalized ketone
From the themed collection: Asymmetric catalysis
23 items

About this collection

We are very pleased to present our 10th Anniversary collection on asymmetric catalysis!

Looking back over the last 10 years, we would like to showcase some of the very best articles that have been published in RSC Advances and Catalysis Science & Technology. Many of these papers have been cited hundreds of times, providing valuable advances for further research, and some continue to be among the journal’s most downloaded articles as of today.

We hope you enjoy our 10th Anniversary collection on asymmetric catalysis!

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