Themed collection Organic Chemistry Frontiers Emerging Investigator Series

This profile article showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator Series.

The synthesis and transformation of α-oxylboronates including their C–B bond and C–O bond functionalizations are reviewed.

Chiral phosphates have successfully been used as ligands in asymmetric metal-catalysis. This Minireview discusses the most recent examples, including main-group catalysis, transition-metal catalysis and catalysis by rare-earth metals.

This review summarizes the synthesis and reactivity of N-aminopyridinium salts, discusses applications in organic synthesis, and highlights the potential for these reagents to enable novel synthetic disconnections and innovations.

In this review, we highlight the recent synthetic methodology development for the formation of C–N and C–O bonds via visible-light-driven nickel catalysis, with in-depth discussions with reaction designs and mechanistic scenarios.

This review summarizes the development status of chiral TADF-active materials with CPEL, covering chiral perturbed TADF molecules, intrinsically chiral TADF molecules, and TADFsensitized fluorescent enantiomers.

In this report, we describe a convergent paired electrochemical decarboxylative C(sp²)–C(sp³) cross-coupling reaction that employs readily available alkyl carboxylic acids and C(sp²)–iodides as direct coupling partners.

A photoredox-assisted nickel-catalyzed reductive coupling of aryl halides and aldehydes to afford silyl-protected alcohols is reported. Key to success of this strategy is to identify α-silylamines as efficient organic reductants.

Herein, we report a tandem asymmetric hydrogenation and S_NAr reaction, providing valuable six- and five-membered chiral benzofused cyclic ethers with high yields and enantioselectivities (up to 99% yield and up to 99% ee).

Pulsed electrolysis waveforms benefit primary benzylic cation generation and fluorination.

Cu(II) Lewis acid/Brønsted base catalysis was employed to achieve enantio- and diastereoselective conjugate additions of pyridyl alkyl ketones to enones, resulting in the formation of various 1,5-diketones with vicinal stereocenters.

A reliable protocol for asymmetric Cu-catalyzed alkynylallylic dimethylamination is described with the discovery of tetramethyldiaminomethane as a new, stable and convenient surrogate of the dimethylamine nucleophile.

Employing the anthracene photodimer core, conjugated figure-of-eight macrocycles are facilely prepared via intramolecular cyclizations followed by ring expansion.

An electrochemical multicomponent reaction (e-MCR) enables the green and sustainable preparation of diverse vicinal sulfenyltetrazolation using the readily available unactivated olefins, thiols, azidotrimethylsilane, and acetonitrile.

The stereochemistry of suffruticosine has been revised by using experimental and computational methods.

We herein report an efficient one-pot strategy for the stereodivergent asymmetric synthesis of various P-atropisomeric Si-stereogenic monohydrosilanes with excellent stereoselectivity from dichlorosilanes.

Cinnamylamines make-up many important drugs that target G protein-coupled receptors.

An efficient pathway to synthesize covalent hydrazone-linked molecular tetrahedra is reported. Our new synthesis enabled us to create a family of hydrolytically stable organic molecular cages with large openings required to bind complex guests.

An effective method for the construction of difluoromethylated alkenes through Cu-catalysed controllable hydrodefluorination of trifluoromethylated alkenes is described.

Remote isodesmic meta-C–H iodination of phenethylamines, benzylamines, and 2-aryl anilines was enabled by an alkyl carboxyl group.

The article explores the intricate relationship between chiroptical properties and molecular symmetry of pyrene-conjugated single and double [7]helicene.

A copper-catalyzed asymmetric [4 + 1] cycloaddition of ethynylbenzoxazinones with sulfur ylides formed in situ by photoinduced carbene transfer is reported to afford chiral indolines with good efficiency, enantio- and diastereoselectivities.

We report herein a practical synthesis of 3,4-diamino-6-azido-1H-pyrazolo[4,3-c]pyridin-5-ium energetic ionic compounds which show good detonation performances and low sensitivities.

A new nickel catalysis strategy that harnesses readily accessible alkyl xanthate esters, while previously well-studied as alkyl radical precursors, herein as ideal sulfenylating agents via an unprecedented C–S bond activation pattern.

In this paper, thia-APEX reactions affording π-extended thianthrene derivatives from unfunctionalized aromatics are described.

A dinuclear zinc catalyst with a pipecolinol-derived tetradentate ligand enables the diverse synthesis of tertiary stereocenters via desymmetrization.

A Ni-catalyzed C–O bond activation is used to access alkenes directly from β-hydroxysulfones.

The bis(pentafluorophenyl)borane-catalyzed E-selective isomerization of terminal alkenes to internal alkenes via a hydroboration/retro-hydroboration sequence is reported.

Visible light-mediated NHC and photoredox co-catalyzed radical 1,2-sulfonylacylation of allenes via cross-coupling between an allyl radical and an NHC-stabilized acyl radical.

The readily available pyrimidinyl sulfones, in which the C–S bond is cleaved selectively, could serve as electrophiles in the Ni-catalyzed cross-coupling reactions to prepare 2,4-diarylated pyrimidines under mild conditions with a broad scope.

The synthesis of discriminated 4,5-disubstitued pyrene from phenangermoles is accomplished via a Pd-catalyzed annulative π-extension reaction.

We describe the Cr-catalyzed enantioconvergent synthesis of chiral 2,3-allenones from aldehydes and propargyl bromides, which features an unprecedented cascade of Cr-catalyzed asymmetric reductive radical–polar crossover and Oppenauer oxidation.