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Themed collection Organic Chemistry Frontiers HOT articles for 2017

59 items
Research Article

Visible-light-induced tandem phosphorylation cyclization of vinyl azides under mild conditions

This method provides a visible-light-induced radical tandem cyclization for the synthesis of phosphorus phenanthridines with various nitrogen-containing substrates.

Graphical abstract: Visible-light-induced tandem phosphorylation cyclization of vinyl azides under mild conditions
Research Article

The hexameric resorcinarene capsule as an artificial enzyme: ruling the regio and stereochemistry of a 1,3-dipolar cycloaddition between nitrones and unsaturated aldehydes

The hexameric resorcinarene capsule as an artificial enzyme to rule the regio and stereochemistry of a 1,3-dipolar cycloaddition.

Graphical abstract: The hexameric resorcinarene capsule as an artificial enzyme: ruling the regio and stereochemistry of a 1,3-dipolar cycloaddition between nitrones and unsaturated aldehydes
Research Article

Synthesis of pyridine trans-tetrafluoro-λ6-sulfane derivatives via radical addition

Pyridine-trans-SF4-alkenes or -alkanes have been synthesized for the first time via the radical addition reactions of pyridine-trans-SF4Cl to alkynes or alkenes in good to high yields.

Graphical abstract: Synthesis of pyridine trans-tetrafluoro-λ6-sulfane derivatives via radical addition
Research Article

Thiazolium salt-catalyzed [3 + 2 + 1] cyclization for the synthesis of trisubstituted 2-pyrones using arylglyoxals as a carbonyl source

A new thiazolium salt-catalyzed [3 + 2 + 1] cyclization of acetylenedicarboxylates with arylglyoxals has been developed, enabling organocatalytic umpolung to access trisubstituted 2-pyrones with good yields via C–C bond cleavage.

Graphical abstract: Thiazolium salt-catalyzed [3 + 2 + 1] cyclization for the synthesis of trisubstituted 2-pyrones using arylglyoxals as a carbonyl source
Research Article

Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

An enantioselective palladium-catalyzed C–H functionalization of pyrroles with diazoacetates has been developed with up to 90% of enantioselectivity.

Graphical abstract: Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand
Research Article

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed with the industrial raw material BrCF2H.

Graphical abstract: Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H
Research Article

An effective approach to aryl-substituted propanoic acids via the Pd-catalyzed hydrocarboxylation of stilbenes

An effective Pd(0)-catalyzed hydrocarboxylation of substituted stilbenes with formic acid and HCOOPh is described. A variety of aryl-substituted propanoic acids are obtained in good yields without using external toxic CO gas.

Graphical abstract: An effective approach to aryl-substituted propanoic acids via the Pd-catalyzed hydrocarboxylation of stilbenes
Research Article

A copper-catalyzed sulfonylative C–H bond functionalization from sulfur dioxide and aryldiazonium tetrafluoroborates

Sulfonylative C–H bond functionalization through a copper-catalyzed three-component reaction of 8-aminoquinoline amides, DABCO·(SO2)2 and aryldiazonium tetrafluoroborates is developed. Excellent selectivity in the para-position is observed.

Graphical abstract: A copper-catalyzed sulfonylative C–H bond functionalization from sulfur dioxide and aryldiazonium tetrafluoroborates
Research Article

Facile synthesis of carbo- and heterocycles via Fe(III)-catalyzed alkene hydrofunctionalization

A facile synthesis of carbo- and heterocycles via Fe(III)-catalyzed alkene hydrofunctionalization has been developed.

Graphical abstract: Facile synthesis of carbo- and heterocycles via Fe(iii)-catalyzed alkene hydrofunctionalization
Research Article

Regioselective C5 alkenylation of 2-acylpyrroles via Pd(II)-catalyzed C–H bond activation

A Pd(II)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles to synthesize various C5-alkenylated 2-acylpyrroles using a readily removable N-protecting group is developed.

Graphical abstract: Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation
Research Article

A copper(I)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles

We have developed a copper/Ph-Phosferrox-catalyzed asymmetric Mannich reaction of Schiff bases with isatin-derived ketimines to prepare 3-substituted 3-aminooxindoles with excellent results.

Graphical abstract: A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles
Research Article

Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

A scandium complex enabled an atom- and step-economical C(sp3)–H addition of N,N-dimethyl anilines to a variety of unactivated alkenes affording branched products.

Graphical abstract: Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes
Research Article

Rearranged limonoids with unique 6/5/6/5 tetracarbocyclic skeletons from Toona ciliata and biomimetic structure divergence

Rearranged limonoids with 6/5/6/5 carbon skeletons, were characterized as metabolite and biomimetic products.

Graphical abstract: Rearranged limonoids with unique 6/5/6/5 tetracarbocyclic skeletons from Toona ciliata and biomimetic structure divergence
Research Article

Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

A small library containing 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was constructed by gold-catalyzed glycosylation.

Graphical abstract: Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin
Research Article

A redox-responsive supramolecular amphiphile fabricated by selenium-containing pillar[5]arene-based host–guest recognition

A novel redox-responsive molecular recognition motif was built between a neutral selenium-containing pillar[5]arene and a pyridinium bromide salt in water. It was further used to construct the first pillararene-based selenium-containing supramolecular amphiphile with application in controlled release.

Graphical abstract: A redox-responsive supramolecular amphiphile fabricated by selenium-containing pillar[5]arene-based host–guest recognition
Research Article

Harnessing the potential diversity of resinic diterpenes through visible light-induced sensitized oxygenation coupled to Kornblum–DeLaMare and Hock reactions

A biomimetic procedure for the late functionalization of resinic acids is reported, implementing photooxygenation by singlet oxygen, using visible light and a photosensitized, combined to the Kornblum–DeLaMare reaction or the Hock rearrangement.

Graphical abstract: Harnessing the potential diversity of resinic diterpenes through visible light-induced sensitized oxygenation coupled to Kornblum–DeLaMare and Hock reactions
Research Article

Tunable regiodivergent phosphine-catalyzed [3 + 2] cycloaddition of alkynones and trifluoroacetyl phenylamides

The regiodivergent phosphine-catalyzed [3 + 2] cycloaddition of 2-(2,2,2-trifluoroacetyl)phenylamides and alkynones have been achieved through adjusting the acidities of substrates, changing reaction temperature and addition of protic additive H2O. The detailed mechanism was systematically studied.

Graphical abstract: Tunable regiodivergent phosphine-catalyzed [3 + 2] cycloaddition of alkynones and trifluoroacetyl phenylamides
Research Article

Comparative investigation of the reactivities between catalysts [Cp*RhCl2]2 and [Cp*IrCl2]2 in the oxidative annulation of isoquinolones with alkynes: a combined experimental and computational study

The origin of the lower reactivity of [Cp*IrCl2]2 relative to [Cp*RhCl2]2 is disclosed and the substituent effects on reactivities are discussed.

Graphical abstract: Comparative investigation of the reactivities between catalysts [Cp*RhCl2]2 and [Cp*IrCl2]2 in the oxidative annulation of isoquinolones with alkynes: a combined experimental and computational study
Research Article

Photoredox meets gold Lewis acid catalysis in the alkylative semipinacol rearrangement: a photocatalyst with a dark side

The alkylative semipinacol rearrangement of a variety of TMS protected α-styrenyl substituted cyclic alcohols with unactivated bromoalkanes that merge photoredox and Au(I)/Au(III) catalysis has been achieved.

Graphical abstract: Photoredox meets gold Lewis acid catalysis in the alkylative semipinacol rearrangement: a photocatalyst with a dark side
Research Article

Garciyunnanimines A–C, novel cytotoxic polycyclic polyprenylated acylphloroglucinol imines from Garcinia yunnanensis

Novel cytotoxic PPAP imines from G. yunnanensis and the biomimetic synthesis of PPAP imines from corresponding PPAPs.

Graphical abstract: Garciyunnanimines A–C, novel cytotoxic polycyclic polyprenylated acylphloroglucinol imines from Garcinia yunnanensis
Research Article

Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

It still remains a major challenge to apply free primary amino groups as the directing group for aliphatic C–H functionalization.

Graphical abstract: Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives
Research Article

Asymmetric SN2′-type C–H functionalization of arenes with propargylic alcohols

The first example of transition metal-catalyzed stereo-defined syn-β-OH elimination! A [Cp*RhCl2]2-catalyzed allenylation reaction of available arenes with propargylic alcohols afforded fully substituted allenes with excellent ees.

Graphical abstract: Asymmetric SN2′-type C–H functionalization of arenes with propargylic alcohols
Open Access Research Article

Concise asymmetric total synthesis of (−)-patchouli alcohol

An asymmetric total synthesis of (−)-patchouli alcohol was realized featuring an enantioselective organocatalytic [4 + 2] approach to the [2.2.2] bicyclic core.

Graphical abstract: Concise asymmetric total synthesis of (−)-patchouli alcohol
Research Article

The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electron-deficient enynes

A series of chiral multisubstituted diquinanes containing three continuous chiral centers are obtained in good yields with excellent enantioselectivities.

Graphical abstract: The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electron-deficient enynes
Research Article

Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

Diphenylmethanamine offers excellent stereocontrol and easy deprotection to provide primary amines in the studied asymmetric reductive amination.

Graphical abstract: Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones
Research Article

Merging photoredox catalysis with transition metal catalysis: site-selective C4 or C5-H phosphonation of 8-aminoquinoline amides

A simple and efficient protocol for the transition metal-catalyzed site-selective C–H phosphonation of 8-aminoquinoline at the C4 or C5 positions via a photoredox process was developed.

Graphical abstract: Merging photoredox catalysis with transition metal catalysis: site-selective C4 or C5-H phosphonation of 8-aminoquinoline amides
Research Article

Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

The first example of a silver-mediated fluorination of alkyl iodides with the Ruppert–Prakash reagent (TMSCF3) as the fluorinating agent is reported.

Graphical abstract: Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent
Research Article

Fe-Catalyzed insertion of fluoromethylcarbenes generated from sulfonium salts into X–H bonds (X = Si, C, P)

The Fe-catalyzed insertion of fluoromethylcarbenes including trifluoromethylcarbene and difluoromethylcarbene into X–H (X = Si, C and P) bonds is described.

Graphical abstract: Fe-Catalyzed insertion of fluoromethylcarbenes generated from sulfonium salts into X–H bonds (X = Si, C, P)
Open Access Research Article

Efficient trifluoromethylation via the cyclopropanation of allenes and subsequent C–C bond cleavage

Trifluoromethyl has been efficiently incorporated into organic skeletons via allene cyclization and C–C bond cleavage.

Graphical abstract: Efficient trifluoromethylation via the cyclopropanation of allenes and subsequent C–C bond cleavage
Research Article

Synthesis of dibromo- and tetrabromo-bipyrrolines and their corresponding 2,6-diazasemibullvalene derivatives

Treatment of Δ1-dipyrrolines with NBS afforded α,α′-dibromo-Δ1-bipyrrolines and α,α,α′,α′-tetrabromo-Δ1-bipyrrolines, which were efficiently transformed into 2,6-diazasemibullvalene derivatives via reduction with lithium.

Graphical abstract: Synthesis of dibromo- and tetrabromo-bipyrrolines and their corresponding 2,6-diazasemibullvalene derivatives
Research Article

A benzothiadiazole-based fluorescent sensor for selective detection of oxalyl chloride and phosgene

A turn-on fluorescent sensor based on benzothiadiazole was constructed for simultaneous selective and visual detection of oxalyl chloride and phosgene.

Graphical abstract: A benzothiadiazole-based fluorescent sensor for selective detection of oxalyl chloride and phosgene
Research Article

Transition-metal-free dehydrogenation coupling of pyridinium through a self-promoted hydride transfer process

An intramolecular dehydrogenation coupling between phenol and pyridinium through a unique substrate self-promoted hydride transfer process has been developed.

Graphical abstract: Transition-metal-free dehydrogenation coupling of pyridinium through a self-promoted hydride transfer process
Research Article

Asymmetric synthesis of chromans via the Friedel–Crafts alkylation–hemiketalization catalysed by an N,N′-dioxide scandium(III) complex

The direct and sequential Friedel–Crafts alkylation/hemiketalization procedures for the synthesis of chiral chromans resulted in excellent yields, high enantioselectivities and high diastereoselectivities for a broad range of substrates.

Graphical abstract: Asymmetric synthesis of chromans via the Friedel–Crafts alkylation–hemiketalization catalysed by an N,N′-dioxide scandium(iii) complex
Research Article

Photoinduced difunctionalization of 2,3-dihydrofuran for the efficient synthesis of 2,3-disubstituted tetrahydrofurans

An efficient photoinduced multicomponent difunctionalization of 2,3-dihydrofuran has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans under mild reaction conditions.

Graphical abstract: Photoinduced difunctionalization of 2,3-dihydrofuran for the efficient synthesis of 2,3-disubstituted tetrahydrofurans
Research Article

The influence of branched alkyl side chains in A–D–A oligothiophenes on the photovoltaic performance and morphology of solution-processed bulk-heterojunction solar cells

Besides providing sufficient solubility, branched alkyl chains also affect the film-forming and packing properties of organic semiconductors.

Graphical abstract: The influence of branched alkyl side chains in A–D–A oligothiophenes on the photovoltaic performance and morphology of solution-processed bulk-heterojunction solar cells
Research Article

Synthesis of pyrazolo[5,1-a]isoquinolines through copper-catalyzed regioselective bicyclization of N-propargylic sulfonylhydrazones

An expeditious strategy for the synthesis of pyrazolo[5,1-a]isoquinolines through copper(II)-catalyzed regioselective bicyclization of N-propargylic sulfonylhydrazones has been developed.

Graphical abstract: Synthesis of pyrazolo[5,1-a]isoquinolines through copper-catalyzed regioselective bicyclization of N-propargylic sulfonylhydrazones
Research Article

Synthesis and conformational structure of hydrazo-bridged homo calix[2]pyridine[2]triazines

Presented in this paper are the practical synthesis and conformational structure of hydrazo-bridged homo calix[4]arenes.

Graphical abstract: Synthesis and conformational structure of hydrazo-bridged homo calix[2]pyridine[2]triazines
Research Article

Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

The copper-catalyzed oxidative amidation of α,β-unsaturated ketones with N-fluorobenzenesulfonimide (NFSI) via a highly regioselective cleavage of C(CO)–C(vinyl) or C(vinyl)–H bonds of ketones has been achieved.

Graphical abstract: Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage
Research Article

Squaramide-catalyzed domino Michael/aza-Henry [3 + 2] cycloaddition: asymmetric synthesis of functionalized 5-trifluoromethyl and 3-nitro substituted pyrrolidines

The diastereo- and enantioselective Michael/aza-Henry [3 + 2] cycloaddition reaction of trifluoromethyl-substituted iminomalonate and nitroalkenes has been developed employing 10 mol% of a quinine-squaramide catalyst.

Graphical abstract: Squaramide-catalyzed domino Michael/aza-Henry [3 + 2] cycloaddition: asymmetric synthesis of functionalized 5-trifluoromethyl and 3-nitro substituted pyrrolidines
Research Article

Asymmetric synthesis of CF3- and indole-containing tetrahydro-β-carbolines via chiral spirocyclic phosphoric acid-catalyzed aza-Friedel–Crafts reaction

An enantioselective aza-Friedel–Crafts reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines has been developed to afford tetrahydro-β-carbolines with a CF3- and indole-containing quaternary stereocenter by using chiral phosphoric acid catalysis.

Graphical abstract: Asymmetric synthesis of CF3- and indole-containing tetrahydro-β-carbolines via chiral spirocyclic phosphoric acid-catalyzed aza-Friedel–Crafts reaction
Research Article

Radical cyclization of benzene-tethered 1,7-enynes with aryldiazonium tetrafluoroborates: a facile route to benzo[j]phenanthridines

A radical cyclization of benzene-tethered 1,7-enynes with aryldiazonium tetrafluoroborates in the presence of copper(II) acetate and DABCO˙(SO2)2 is developed, leading to diverse benzo[j]phenanthridines.

Graphical abstract: Radical cyclization of benzene-tethered 1,7-enynes with aryldiazonium tetrafluoroborates: a facile route to benzo[j]phenanthridines
Research Article

Direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3

A copper-catalyzed direct oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3 has been developed.

Graphical abstract: Direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3
Research Article

Copper-catalyzed highly selective approach to 2-boroallylic silanes from allenylsilanes

A highly selective copper-catalyzed borylcupration of 1,2-allenylsilanes affords 2-borylallylsilanes with many synthetically attractive functional groups by applying BIPHEP as the ligand has been developed.

Graphical abstract: Copper-catalyzed highly selective approach to 2-boroallylic silanes from allenylsilanes
Research Article

Highly enantioselective nitro-Mannich reaction of ketimines under phase-transfer catalysis

A novel bifunctional phase-transfer catalyst 1i was found to be highly efficient for the nitro-Mannich reaction of unactivated ketone-derived imines with the introduction of the protecting group 6-methyl-2-pyridylsulfonyl to the ketimines. Density functional theory (DFT) calculations are also performed to give the possible transition-state model.

Graphical abstract: Highly enantioselective nitro-Mannich reaction of ketimines under phase-transfer catalysis
Open Access Research Article

Enantioselective synthesis of naturally occurring isoquinoline alkaloids: (S)-(−)-trolline and (R)-(+)-oleracein E

The highly efficient asymmetric synthesis of a pair of enantiomers, (S)-(−)-trolline and (R)-(+)-oleracein E, has been achieved in five steps.

Graphical abstract: Enantioselective synthesis of naturally occurring isoquinoline alkaloids: (S)-(−)-trolline and (R)-(+)-oleracein E
Research Article

Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts

An iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts has been developed, affording products with up to 96% ee.

Graphical abstract: Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts
Research Article

A facile approach to ketones via Pd-catalyzed sequential carbonylation of olefins with formic acid

An effective palladium-catalyzed sequential carbonylation of olefins with formic acid is described.

Graphical abstract: A facile approach to ketones via Pd-catalyzed sequential carbonylation of olefins with formic acid
Research Article

Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

Facile assembly of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide starting from anilines, N-arylacrylamides and DABCO·(SO2)2 is realized.

Graphical abstract: Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source
Research Article

A chiral ion-pair photoredox organocatalyst: enantioselective anti-Markovnikov hydroetherification of alkenols

A chiral ion-pair photoredox organocatalyst was reported to facilitate visible-light-meditated asymmetric anti-Markovnikov hydroetherification of alkenols with high reactivity and moderate enantioselectivity.

Graphical abstract: A chiral ion-pair photoredox organocatalyst: enantioselective anti-Markovnikov hydroetherification of alkenols
Research Article

KBr/K2S2O8-mediated dibromohydration of N-(2-alkynylaryl)acetamide

A neighbouring acetamino group-participated regioselective dibromohydration of N-(2-alkynylaryl)acetamide is described here for the synthesis of N-(2-(2,2-dibromo-2-arylacetyl)aryl)acetamide.

Graphical abstract: KBr/K2S2O8-mediated dibromohydration of N-(2-alkynylaryl)acetamide
Open Access Research Article

(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Optically pure reagents that are able to deliver a trifluoromethylthio group with good to excellent enantioselectivities.

Graphical abstract: (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation
Research Article

Thiolate–palladium(IV) or sulfonium–palladate(0)? A theoretical study on the mechanism of palladium-catalyzed C–S bond formation reactions

Thiolate–palladium(IV) intermediates are generated through oxidative addition in our suggested mechanisms, and are the key intermediates in these catalytic cycles.

Graphical abstract: Thiolate–palladium(iv) or sulfonium–palladate(0)? A theoretical study on the mechanism of palladium-catalyzed C–S bond formation reactions
Research Article

Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives

A phosphine-mediated γ-umpolung/Wittig/γ-umpolung reaction between phthalimidomalonates and allenoates/but-2-ynoate furnishes highly functionalized pyrroloisoindolinone derivatives in synthetically useful yields.

Graphical abstract: Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives
Open Access Research Article

The impact of interplay between electronic and steric effects on the synthesis and the linear and non-linear optical properties of diketopyrrolopyrrole bearing benzofuran moieties

Benzofuran has been proven to be the versatile substituent for tuning the optics of diketopyrrolopyrroles.

Graphical abstract: The impact of interplay between electronic and steric effects on the synthesis and the linear and non-linear optical properties of diketopyrrolopyrrole bearing benzofuran moieties
Research Article

5-Azadibenzo[a,g]corannulene

The first azacorannulene with a nitrogen on the rim, has been synthesized in seven steps from 4-bromoisoquinoline.

Graphical abstract: 5-Azadibenzo[a,g]corannulene
Research Article

From tetrabenzoheptafulvalene to sp2 carbon nano-rings

A new kind of sp2 carbon nano-rings containing a heptagon and an octagon was synthesized by taking advantage of the “C” shape of syn-tetrabenzoheptafulvalene.

Graphical abstract: From tetrabenzoheptafulvalene to sp2 carbon nano-rings
Open Access Research Article

Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution

The AgNO3-catalyzed carbofluorination of unactivated alkenes with acetic acid provides an efficient and general route to γ-fluorinated carboxylic acids.

Graphical abstract: Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution
Research Article

Iridium catalysts with modular axial-unfixed biphenyl phosphine–oxazoline ligands: asymmetric hydrogenation of α,β-unsaturated carboxylic acids

Axial-unfixed biphenyl phosphine–oxazoline ligands were successfully applied to Ir-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids.

Graphical abstract: Iridium catalysts with modular axial-unfixed biphenyl phosphine–oxazoline ligands: asymmetric hydrogenation of α,β-unsaturated carboxylic acids
Research Article

One-pot synthesis of fluorescent 2,4-dialkenylindoles by rhodium-catalyzed dual C–H functionalization

A one-pot synthesis of fluorescent 2,4-dialkenylindoles by rhodium-catalyzed dual C–H bond alkenylation of indoles.

Graphical abstract: One-pot synthesis of fluorescent 2,4-dialkenylindoles by rhodium-catalyzed dual C–H functionalization
59 items

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Read some of the best research published from Organic Chemistry Frontiers in 2017. These articles are recommended by reviewers as being of significant novelty and interest.

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