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Themed collection Neglected Tropical Diseases

19 items
Editorial

Introduction to the themed collection on ‘Neglected tropical diseases’

Guest editors Nahid Ali, Steven L. Cobb and Charles Mowbray introduce the themed collection on ‘Neglected tropical diseases’.

Graphical abstract: Introduction to the themed collection on ‘Neglected tropical diseases’
From the themed collection: Neglected Tropical Diseases
Open Access Review Article

Pharmacokinetics and pharmacodynamics in the treatment of cutaneous leishmaniasis – challenges and opportunities

Important pharmacokinetic and -dynamic parameters for the drug discovery and development of new treatments for cutaneous leishmaniasis.

Graphical abstract: Pharmacokinetics and pharmacodynamics in the treatment of cutaneous leishmaniasis – challenges and opportunities
From the themed collection: Neglected Tropical Diseases
Open Access Review Article

Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases

This review highlights the key roles of proteomic techniques in the study of Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei parasites.

Graphical abstract: Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases
From the themed collection: Neglected Tropical Diseases
Review Article

Recent progress on phenotype-based discovery of dengue inhibitors

The review presents the discovery of new dengue inhibitors by a phenotype-based approach.

Graphical abstract: Recent progress on phenotype-based discovery of dengue inhibitors
From the themed collection: Neglected Tropical Diseases
Review Article

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

After a century since the first antimonial-based drugs were introduced to treat the disease, anti-schistosomiasis drug development is again at a bottleneck with only one drug, praziquantel, available for treatment purposes.

Graphical abstract: Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?
From the themed collection: Neglected Tropical Diseases
Open Access Research Article

Collaborative virtual screening to elaborate an imidazo[1,2-a]pyridine hit series for visceral leishmaniasis

Ligand-based similarity screening of proprietary pharmaceutical company libraries enables rapid hit to lead investigation of a chemotype with anti-leishmania activity.

Graphical abstract: Collaborative virtual screening to elaborate an imidazo[1,2-a]pyridine hit series for visceral leishmaniasis
From the themed collection: Neglected Tropical Diseases
Research Article

A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

Water-soluble oxadiazole-based HKT inhibitor library, comprising a new class of compounds for control of Aedes aegypti dissemination, act as competitive HKT enzyme inhibitors, promoting accumulation of the toxic metabolite 3-hydroxykynurenine in insect organism.

Graphical abstract: A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti
From the themed collection: Neglected Tropical Diseases
Research Article

Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR

P218 is a potent inhibitor of M. ulcerans DHFR (Ki 3.2 nM).

Graphical abstract: Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR
From the themed collection: Neglected Tropical Diseases
Open Access Research Article

Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents

A series of benzene sulphonamides with good potency and selectivity against Leishmania spp. intracellular amastigotes was identified by high-throughput screening.

Graphical abstract: Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
From the themed collection: Neglected Tropical Diseases
Open Access Research Article

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

The development of a chemical series with oral efficacy against visceral leishmaniasis is described.

Graphical abstract: Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis
From the themed collection: Neglected Tropical Diseases
Research Article

Antileishmanial assessment of isoxazole derivatives against L. donovani

The antileishmanial activity of a variety of 3-nitro and 3-amino-isoxazoles against promastigote and amastigote stages of L. donovani is described.

Graphical abstract: Antileishmanial assessment of isoxazole derivatives against L. donovani
From the themed collection: Neglected Tropical Diseases
Research Article

Structure–property studies of an imidazoquinoline chemotype with antitrypanosomal activity

Structure–property and structure–activity studies identify regions that positively modulate aqueous solubility; though maintaining potent anti-trypanosomal potency proves challenging.

Graphical abstract: Structure–property studies of an imidazoquinoline chemotype with antitrypanosomal activity
From the themed collection: Neglected Tropical Diseases
Research Article

Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B

L. infantum isolates from an outbreak of canine leishmaniasis were obtained. Drug sensitivity assays and infectivity studies show significant differences with reference strains.

Graphical abstract: Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B
From the themed collection: Neglected Tropical Diseases
Research Article

Drug combinations as effective anti-leishmanials against drug resistant Leishmania mexicana

Synergistic and antagonist drug interactions of drug combinations against Leishmania drug sensitive and resistant cell lines.

Graphical abstract: Drug combinations as effective anti-leishmanials against drug resistant Leishmania mexicana
From the themed collection: Neglected Tropical Diseases
Research Article

Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei

Potent T. brucei methionyl-tRNA synthetase inhibitors built on two novel short and rigid linker systems.

Graphical abstract: Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
From the themed collection: Neglected Tropical Diseases
Open Access Research Article

An investigation of the antileishmanial properties of semi-synthetic saponins

Hit anti-leishmanial saponin structures selected following primary and secondary screening.

Graphical abstract: An investigation of the antileishmanial properties of semi-synthetic saponins
From the themed collection: Neglected Tropical Diseases
Research Article

Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides

A series of benzimidazole phenylacetamides were developed from a phenotypic hit as novel trypanosomacides for Chagas disease and human African trypanosomiasis.

Graphical abstract: Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides
From the themed collection: Neglected Tropical Diseases
Research Article

Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors

A quantum chemistry guided optimisation (leading to piceatannol analogue 3t) with a good understanding of the catechol binding mode to the bimanganese cluster of arginase.

Graphical abstract: Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors
From the themed collection: Neglected Tropical Diseases
Open Access Research Article

Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei

2-{2-[3-(1-Adamantyl)-4-fluorophenyl]thiazol-4-yl}ethan-1-amine (1a) and 2-{2-[4-(1-adamantyl)phenyl]thiazol-4-yl}ethan-1-amine (2a) exhibit activity against T. brucei in the range of IC50 = 0.42 μM and IC50 = 0.80 μM, respectively.

Graphical abstract: Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei
From the themed collection: Neglected Tropical Diseases
19 items

About this collection

Guest edited by Dr Charles Mowbray (DNDi), Professor Nahid Ali (IICB, Bombay) and Professor Steven Cobb (Durham University), this collection aims to highlight the exciting research and ongoing efforts to target Neglected Tropical Diseases.

New articles will be added to the collection upon publication. Please return to this page frequently to see the collection grow.

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