Materials for biosurfaces
Guest editors Christian Ohm, M. Elizabeth Welch and Christopher K. Ober introduce this Journal of Materials Chemistry themed issue on Materials for biosurfaces.
Biomimetic functionalization of porous substrates: towards model systems for cellular membranes
Herein we present applications for arrays of nano- to micrometre sized pores in membrane research and as biosensors.
Switchable adhesion by chemical functionality and topography
This feature article discusses recent advances of “smart” adhesives with reversibly switchable adhesion properties controlled by chemical modification or surface topography.
Cell and cell sheet recovery from pNIPAm coatings; motivation and history to present day approaches
A comprehensive review highlighting the major developments of thermoresponsive cell platforms in regenerative culture.
Utilizing click chemistry to design functional interfaces through post-polymerization modification
Post-polymerization modification using click chemistry is highlighted in this feature article as an effective method to add complex functionality to a polymeric interface.
Biomimetic 3D self-assembling biomicroconstructs by spontaneous deformation of thin
The manuscript overviews recent advance in the development and application of wrinkling, creasing and folding polymer films in biotechnology.
dextran hydrogel films as substrates for osteoblast and endothelial cell growth
Functional hydrogel films on solid supports are versatile materials with large potential for cell growth and tissue engineering.
It takes walls and knights to defend a castle – synthesis of surface coatings from antimicrobial and antibiofouling
A novel bifunctional material consisting of a poly(oxonorbornene)-based antibiofouling poly(zwitterion) grafted onto a surface-immobilized poly(oxonorbornene)-based antimicrobial polymer network is presented.
Reversible swelling of
chitosan and quaternary ammonium modified chitosan brush layers: effects of pH and counter anion size and functionality
We describe the swelling behaviour of chitosan and quaternary ammonium modified chitosan brush layers depending on degree of substitution of quaternary ammonium salts, pH, and counter-anion type using a quartz-crystal microbalance with dissipation.
A covalently modified hydrogel blend of hyaluronan–methyl cellulose with peptides and growth factors influences neural stem/progenitor cell fate
Conjugation of platelet-derived growth factor-A and a cell-adhesive peptide to an injectable hydrogel increases neural stem cell differentiation into oligodendrocytes, for ultimate application in cell delivery.
protein resistance of silicones prepared with a PEO-silane amphiphile
Silicone coatings with improved resistance to plasma proteins were prepared by incorporating a PEO-silane amphiphile: α-(EtO)3Si-(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide)8-OCH3.
Electrospinning of in situ crosslinked collagen nanofibers
A simple one-step approach to electrospin Type I collagen in the presence of the chemical crosslinking agents 1-ethyl-3-(3-dimethyl-aminopropyl)-1-carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) has been developed to generate water-insoluble collagen nanofiber scaffolds without the need for post-crosslinking.
Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes
Natural bone extracellular matrix mimetic surface coatings were prepared by surface-initiated atom transfer radical copolymerization of 2-hydroxyethyl methacrylate and 2-(methacryloyloxy)ethyl phosphate and subsequent peptide post-modification.
Dynamically cell separating thermo-functional biointerfaces with densely packed
Thermo-responsive polymer brush grafted glass surfaces with various brush lengths were prepared through surface-initiated ATRP as cell separating intelligent biointerfaces. A precisely designed PIPAAm brush is able to separate cells by the utilization of different detachment properties of cells from the surfaces.
Crosslink density of a biomimetic poly(HEMA)-based hydrogel influences growth and proliferation of attachment dependent RMS 13 cells
Attachment dependent RMS 13 human muscle fibroblasts demonstrate adaptive attachment dependence on the bound water content within poly(HEMA) hydrogels.
lipid bilayers with high cholesterol content formed by α-helical peptide-induced vesicle fusion
We present a technique to create complex, high cholesterol-containing supported lipid bilayers using α-helical peptide-induced vesicle fusion.
Influence of surface charge and protein intermediary layer on the formation of biomimetic calcium phosphate on silica nanoparticles
Formation of biomimetic calcium phosphate nano-composite through protein mediated manipulation of substrate charge characteristics.
Dendritic polyglycerolamine as a functional antifouling coating of gold surfaces
Coating gold substrates with PG-amino monolayers is a useful strategy for producing surfaces with defined (bio)specific bindings as well as protein repellant properties.
Combinatorial screening of chemically defined human mesenchymal stem cell culture substrates
SAM array technology was used to investigate the effects of multiple, distinct peptides and peptide combinations on human mesenchymal stem cell behavior.
Thiol-ene “click” networks from amphiphilic fluoropolymers: full synthesis and characterization of a benchmark anti-biofouling surface
Photo-initiated, thiol-ene crosslinking has been employed to generate nanoscopically complex, heterogeneous surfaces that resist protein adsorption.
Protein-resistant polymer surfaces
Neutral, water-swollen polymer coatings effectively repel proteins through ‘entropic shielding’ which makes them excellent candidates as non-fouling materials.
Electrochemically stimulated release of lysozyme from an alginate matrix cross-linked with iron cations
An electrochemically generated alginate matrix cross-linked with Fe3+ cations was used to entrap lysozyme and then release it upon application of an electrochemical signal.
PEDOT:TOS with PEG: a biofunctional surface with improved electronic characteristics
Devices based on conducting polymers offer great promise for interfacing with cells.
peptide amphiphile hydrogel designed for applications in regenerative medicine with potential as injectable tissue scaffolds
Tailoring properties of peptide amphiphile assemblies for therapeutic applications through molecular design.
Antimicrobial efficacy and optimized cell adhesion from defined plasma polymerised multilayer structures involving
zinc acetylacetonate and allylamine
A multilayer structure comprising of a zinc burst release system and a cytocompatible plasma polymer top-coating is discussed with the concept of developing antimicrobial, yet biocompatible coatings suitable for use on implants and medical devices.
Biocompatible stimuli-responsive hydrogel porous membranes via phase separation of a polyvinyl alcohol and Na-alginate intermolecular complex
Stimuli-responsive porous hydrogel thin films fabricated from sodium alginate and polyvinyl alcohol via a spinodal decomposition mechanism in a low immiscibility limit.
proteins for use as versatile bioactive materials and surface coatings
A cell-adhesive elastin-like protein biomaterial enables photocrosslinking into stable coatings, films, and scaffolds across the nanometre to millimetre length scales.
chitosan assemblies for chronic wounds treatment: control of enzyme activity and cell attachment
Surface active multilayered coatings comprising thiolated chitosan and glycosaminoglycans inhibit enzymes related to chronic inflammation and display tuneable fibroblast attachment.
Bacterial adherence on self-assembled films of brush
polymers bearing zwitterionic sulfobetaine moieties
The adherences of bacteria on self-assembled films of sulfobetaine-containing brush polymers were quantitatively investigated in aspects of surface characteristics and thermodynamics.
About this collection
Journal of Materials Chemistry presents a themed issue on ‘Materials for biosurfaces’ with guest editors Christian Ohm, M. Elizabeth Welch and Christopher K. Ober.