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Issue 37, 2012
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Biocompatible stimuli-responsive hydrogel porous membranes via phase separation of a polyvinyl alcohol and Na-alginate intermolecular complex

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Abstract

Ion cross-linked porous alginate thin films were fabricated from mixtures of sodium alginate and polyvinyl alcohol (PVA) in an aqueous solution. A spinodal decomposition mechanism in a low immiscibility limit brings about the formation of phase separated spin-cast thin films that are characterized with a low size distribution of PVA phases. Rinsing of the films in calcium chloride solutions yields porous hydrogel films – membranes on solid substrates. The porous membranes are a pH-sensitive material whose pore diameter can be tuned by changes in pH. The membranes are mechanically robust and can be transferred onto the surface of porous substrates.

Graphical abstract: Biocompatible stimuli-responsive hydrogel porous membranes via phase separation of a polyvinyl alcohol and Na-alginate intermolecular complex

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Article information


Submitted
21 Mar 2012
Accepted
30 Apr 2012
First published
30 Apr 2012

J. Mater. Chem., 2012,22, 19482-19487
Article type
Paper

Biocompatible stimuli-responsive hydrogel porous membranes via phase separation of a polyvinyl alcohol and Na-alginate intermolecular complex

V. Gopishetty, I. Tokarev and S. Minko, J. Mater. Chem., 2012, 22, 19482
DOI: 10.1039/C2JM31778H

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