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Issue 37, 2012
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The protein resistance of silicones prepared with a PEO-silane amphiphile

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Abstract

Silicone coatings with improved resistance to plasma proteins were prepared by incorporating a PEO-silane amphiphile: α-(EtO)3Si-(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide)8-OCH3. The oligodimethylsiloxane tether imparts amphiphilicity and molecular mobility to the chain thereby enhancing protein resistance. Using a medical grade, silica-filled acetoxy-cure silicone, the PEO-silane amphiphile was introduced at varying levels (0, 1, 5, 10, 15 and 20 wt%) and films prepared via solvent-casting. Increased PEO-silane amphiphile content led to increased surface hydrophilicity and improved resistance to bovine serum albumin (BSA) and human fibrinogen (HF). When maintained in air, the surfaces of the coatings did not display hydrophobic recovery.

Graphical abstract: The protein resistance of silicones prepared with a PEO-silane amphiphile

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Supplementary files

Article information


Submitted
14 Apr 2012
Accepted
12 Jul 2012
First published
13 Jul 2012

J. Mater. Chem., 2012,22, 19540-19546
Article type
Paper

The protein resistance of silicones prepared with a PEO-silane amphiphile

M. L. Hawkins and M. A. Grunlan, J. Mater. Chem., 2012, 22, 19540
DOI: 10.1039/C2JM32322B

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