The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex
Bcl-xL inhibits tBid and Bax via distinct mechanisms
Modulation of host cell membrane nano-environment by mycobacterial glycolipids: Involvement of PI(4,5)P2 signaling lipid?
The Impact of Antibacterial Peptides on Bacterial Lipid Membranes Depends on Stage of Growth
Structural changes in the model of the outer cell membrane of Gram-negative bacteria interacting with melittin: An in situ spectroelectrochemical study
About this collection
We are delighted to share with you a selection of the papers associated with a Faraday Discussion on Peptide-membrane interactions. More information about the event may be found here: http://rsc.li/peptide-fd2020. Additional articles will be added to the collection as they are published. The final versions of all the articles presented and a record of the live discussions will be published after the event.
It is difficult to overstate the importance of improving our understanding of how macromolecules such as peptides interact with membranes as this is such a fundamental aspect of how living systems operate. These processes are involved in protein folding, cell signalling, biogenesis, morphogenesis, disease and medical therapy. Next-generation synthetic biology goals will require a clearer understanding of how to control reticulated membrane structures in order to fabricate the supramolecular structures necessary for advanced synthesis and behaviour.
The molecular questions that require clarification and their solutions bridge the many divides between the fundamental physical chemistry of macromolecular polyelectrolytes and the supramolecular chemistry of membrane assemblies related to cell biology as well as drug development and synthetic biology. This Discussion meeting will seek to establish a sound platform for further developments in this important field by addressing several related aspects of peptide interactions with membranes. It will consider model theoretical and experimental systems in order to define the ‘reaction space’ that is possible and where appropriate with relevance to fundamental questions in cell biology including how peptides and proteins behave within biological membranes