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Themed collection Nanotoxicology

33 items
Feature Article

Nanoparticle–blood interactions: the implications on solid tumour targeting

This review examines nanoparticle–blood interactions, their implications on solid tumour targeting, and provides an outlook to guide future nanoparticle design.

Graphical abstract: Nanoparticle–blood interactions: the implications on solid tumour targeting
From the themed collection: Nanotoxicology
Open Access Review Article

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

Besides the wide use of engineered nanomaterials (NMs) in technical products, their applications are not only increasing in biotechnology and biomedicine, but also in the environmental field.

Graphical abstract: The nanoparticle biomolecule corona: lessons learned – challenge accepted?
From the themed collection: Nanotoxicology
Review Article

Silver nanoparticles – wolves in sheep's clothing?

We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.

Graphical abstract: Silver nanoparticles – wolves in sheep's clothing?
From the themed collection: Nanotoxicology
Review Article

Upconverting nanoparticles: assessing the toxicity

Based on a survey of existing studies, low nanotoxicity of lanthanide doped upconverting nanoparticles holds promise for their safety and suitability for biomedical detection and imaging.

Graphical abstract: Upconverting nanoparticles: assessing the toxicity
From the themed collection: Nanotoxicology
Review Article

Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms

An increasing number of publications report genotoxicity studies for metal oxide and silica nanomaterials which may induce different kinds of genotoxicity via a variety of mechanisms.

Graphical abstract: Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms
From the themed collection: Nanotoxicology
Review Article

Perturbation of physiological systems by nanoparticles

Nanoparticle translocation and potential toxicity at the physiological system level.

Graphical abstract: Perturbation of physiological systems by nanoparticles
From the themed collection: Nanotoxicology
Tutorial Review

Physical, chemical, and in vitro toxicological characterization of nanoparticles in chemical mechanical planarization suspensions used in the semiconductor industry: towards environmental health and safety assessments

This tutorial review focuses on aqueous slurries of dispersed engineered nanoparticles (ENPs) used in chemical mechanical planarization (CMP) for polishing wafers during manufacturing of semiconductors.

Graphical abstract: Physical, chemical, and in vitro toxicological characterization of nanoparticles in chemical mechanical planarization suspensions used in the semiconductor industry: towards environmental health and safety assessments
From the themed collection: Nanotoxicology
Communication

Toxicity of halloysite clay nanotubes in vivo: a Caenorhabditis elegans study

Halloysite nanotubes in the C. elegans foregut (merged enhanced dark-field and fluorescence images).

Graphical abstract: Toxicity of halloysite clay nanotubes in vivo: a Caenorhabditis elegans study
From the themed collection: Nanotoxicology
Communication

In vitro fluorescence and phototoxicity of β-SnWO4 nanoparticles

The nanoparticulate photocatalyst β-SnWO4 is transfected into human liver carcinoma cells (HepG2).

Graphical abstract: In vitro fluorescence and phototoxicity of β-SnWO4 nanoparticles
From the themed collection: Nanotoxicology
Open Access Edge Article

Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria

Higher cationic charge density on nanoparticles is correlated with higher toxicity to bacteria.

Graphical abstract: Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria
From the themed collection: Nanotoxicology
Paper

Silica nanoparticles induced the pre-thrombotic state in rats via activation of coagulation factor XII and the JNK-NF-κB/AP-1 pathway

The pre-thrombotic state induced by SiNPs via the interaction between platelet activation, coagulation hyperfunction, anti-coagulation and fibrinolytic resistance.

Graphical abstract: Silica nanoparticles induced the pre-thrombotic state in rats via activation of coagulation factor XII and the JNK-NF-κB/AP-1 pathway
From the themed collection: Nanotoxicology
Paper

Partial protection of N-acetylcysteine against MPA-capped CdTe quantum dot-induced neurotoxicity in rat primary cultured hippocampal neurons

CdTe QD exposure caused death and apoptosis of rat primary cultured hippocampal neurons via generating reactive oxygen species and increasing intracellular calcium levels, which could be reversed by a common antioxidant NAC.

Graphical abstract: Partial protection of N-acetylcysteine against MPA-capped CdTe quantum dot-induced neurotoxicity in rat primary cultured hippocampal neurons
From the themed collection: Nanotoxicology
Paper

Synthesis and in vivo toxicity assessment of CdSe:ZnS quantum dots functionalized with EDTA-Bis-Cysteamine

Synthesis and in vivo toxicity assessment of radiolabeled Bis-ligand functionalized core shell quantum dot.

Graphical abstract: Synthesis and in vivo toxicity assessment of CdSe:ZnS quantum dots functionalized with EDTA-Bis-Cysteamine
From the themed collection: Nanotoxicology
Paper

Toxicity of exfoliated-MoS2 and annealed exfoliated-MoS2 towards planktonic cells, biofilms, and mammalian cells in the presence of electron donor

EDTA, as an electron donor, used for the first time in the antibacterial study of MoS2.

Graphical abstract: Toxicity of exfoliated-MoS2 and annealed exfoliated-MoS2 towards planktonic cells, biofilms, and mammalian cells in the presence of electron donor
From the themed collection: Sustainable Nanotechnology Organization 2014
Paper

Biocompatibility studies on lanthanum oxide nanoparticles

Biocompatibility on lanthanum oxide nanoparticles (LONP) were investigated. LONP was cytotoxic to balb/3T3 cells via release of ROS. LONP and/or extracts were non-irritant, non-sensitizer and non-mutagenic. LONP extracts did not show acute systemic toxicity. Whereas, LONP exerted hepatotoxicity following oral administration.

Graphical abstract: Biocompatibility studies on lanthanum oxide nanoparticles
From the themed collection: Nanotoxicology
Paper

Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?

Among the toxicity mechanisms linked to nanoparticles (NPs), oxidative stress (OS) and inflammation are, in general, presumed to mediate their toxicological responses.

Graphical abstract: Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?
From the themed collection: Nanotoxicology
Paper

Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy

GO can extract the lipid bilayer of RBCs membranes, resulting in hemolysis and aberrant forms. In contrast, GQDs just disturb the structure and conformation of the lipid, resulting in only aberrant cells.

Graphical abstract: Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy
From the themed collection: Nanotoxicology
Open Access Paper

Quantum dot induced cellular perturbations involving varying toxicity pathways

Quantum dots (QD) with varying surface chemistry can have an impact on cellular uptake and a range of indicators for cell perturbation.

Graphical abstract: Quantum dot induced cellular perturbations involving varying toxicity pathways
From the themed collection: Nanotoxicology
Paper

Uptake of gold nanoparticles in primary human endothelial cells

Single-particle resolution techniques show that endothelial cells internalise 80 nm unmodified gold nanoparticles by endocytosis with subsequent transport to vesicles.

Graphical abstract: Uptake of gold nanoparticles in primary human endothelial cells
Paper

Toxic effect comparison of three typical sterilization nanoparticles on oxidative stress and immune inflammation response in rats

Three typical sterilization nanoparticles can cause oxidative stress and immune inflammation response to rats, and their toxicities showed significant differences.

Graphical abstract: Toxic effect comparison of three typical sterilization nanoparticles on oxidative stress and immune inflammation response in rats
From the themed collection: Nanotoxicology
Paper

Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-β signalling

Cerium oxide nanoparticles attenuate oxidative stress induced alterations in TGF-β signalling pathway members.

Graphical abstract: Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-β signalling
From the themed collection: Hot articles in Toxicology Research
Paper

A gene signature for gold nanoparticle-exposed human cell lines

A unique four-gene signature for AuNP exposure was identified using the cDNA microarray and evaluated by qPCR and biological assays in mammalian cell lines.

Graphical abstract: A gene signature for gold nanoparticle-exposed human cell lines
From the themed collection: Nanotoxicology
Paper

Cytotoxic effects and cellular oxidative mechanisms of metallic nanoparticles on renal tubular cells: impact of particle solubility

Many uncertainties remain regarding the potential toxic effect of nanoparticles.

Graphical abstract: Cytotoxic effects and cellular oxidative mechanisms of metallic nanoparticles on renal tubular cells: impact of particle solubility
From the themed collection: Nanotoxicology
Paper

Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway

TiO2 nanoparticles enhance LPS-dependent NO production and cytokine secretion through a mechanism that involves TLR4-mediated p38-signalling and requires phagocytosis.

Graphical abstract: Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway
From the themed collection: Nanotoxicology
Paper

Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans

Nitrogen-doped graphene quantum dots (N-GQDs) are safe for environmental release.

Graphical abstract: Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans
Paper

Taurine attenuates nano-copper-induced oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway

Effect of taurine of propidium iodine staining on nano copper induced liver tissue.

Graphical abstract: Taurine attenuates nano-copper-induced oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway
From the themed collection: Nanotoxicology
Paper

Computer-aided nanotoxicology: assessing cytotoxicity of nanoparticles under diverse experimental conditions by using a novel QSTR-perturbation approach

This work focuses on creating a QSTR-perturbation model to enable computer-aided predictions of cytotoxicity of nanoparticles under dissimilar experimental conditions.

Graphical abstract: Computer-aided nanotoxicology: assessing cytotoxicity of nanoparticles under diverse experimental conditions by using a novel QSTR-perturbation approach
From the themed collection: Nanotoxicology
Paper

The toxic effects of single-walled carbon nanotubes are linked to the phagocytic ability of cells

We show here that the phagocytic ability of cells exposed to single-walled carbon nanotubes is directly correlated to the toxic effects to the cells.

Graphical abstract: The toxic effects of single-walled carbon nanotubes are linked to the phagocytic ability of cells
From the themed collection: Nanotoxicology
Open Access Paper

A general mechanism for intracellular toxicity of metal-containing nanoparticles

We demonstrate a general mechanism for the toxicity induced by metal-containing NPs, named “lysosome-enhanced Trojan horse effect”, which provides design rules to engineer safer NPs.

Graphical abstract: A general mechanism for intracellular toxicity of metal-containing nanoparticles
From the themed collection: Nanotoxicology
Paper

Reducing ZnO nanoparticle cytotoxicity by surface modification

ZnO surface properties control cytotoxicity by regulating nanoparticle uptake rather than by altering either intracellular or extracellular Zn dissolution rates.

Graphical abstract: Reducing ZnO nanoparticle cytotoxicity by surface modification
From the themed collection: Nanotoxicology
Paper

Reaction of monocytes to polystyrene and silica nanoparticles in short-term and long-term exposures

The increased use of nanoparticles (NPs) in industrial, health and consumer products may cause short-term and long-term cellular effects.

Graphical abstract: Reaction of monocytes to polystyrene and silica nanoparticles in short-term and long-term exposures
From the themed collection: Nanotoxicology
Paper

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells

This study has shown that the haemolytic activity and toxicity of phytantriol cubosomes is considerably greater than that of glycerol monooleate cubosomes.

Graphical abstract: Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
From the themed collection: Nanotoxicology
Paper

Comparative cytotoxicity of cadmium forms (CdCl2, CdO, CdS micro- and nanoparticles) in renal cells

Cadmium (Cd) is a potent selective toxicant that preferentially accumulates in the kidneys where it is known to induce cellular injury.

Graphical abstract: Comparative cytotoxicity of cadmium forms (CdCl2, CdO, CdS micro- and nanoparticles) in renal cells
From the themed collection: Nanotoxicology
33 items

About this collection

This web collection contains a selection of articles and reviews on the theme of nanotoxicology. Nanomaterials are used in many industry sectors including the biomedical sciences, catalysis, and much more. As such, it has become increasingly important to investigate the potential risks and health impacts associated with nanomaterial exposure. This collection of papers provides insights into the toxicological effects of rare earth, noble metal, carbon, silica, and lipid nanomaterials in various systems, and the impacts for health and disease.

Additional papers on the theme of nanotoxicology in the environment can be found in the Environmental Science: Nano collection, Guest Edited by Kristin Schirmer and Melanie Auffan: http://rsc.li/nanotox

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